Effects of mitotane on testicular adrenal rest tumors in congenital adrenal hyperplasia due to 21-hydroxylase deficiency - a retrospective series of five patients - Institut de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition Accéder directement au contenu
Article Dans Une Revue European Journal of Endocrinology Année : 2021

Effects of mitotane on testicular adrenal rest tumors in congenital adrenal hyperplasia due to 21-hydroxylase deficiency - a retrospective series of five patients

Résumé

We conducted a retrospective study on the long-term effect of mitotane treatment on testicular adrenal rest tumors (TARTs) in 5 adult patients with classic 21-hydroxylase deficiency,. After 60 months of mitotane treatment, a decrease of adrenal steroids was observed in 4 patients. Testicular ultrasonography showed complete disappearance of TART in 2 patients, stabilization in 2 patients and a halving of TART volume in the remaining patient. Sperm count improved notably in 2 patients who had normal baseline inhibin B levels and small inclusions, thus enabling cryopreservation of the subjects’ semen. Four years of follow-up of these two patients after the withdrawal of mitotane showed no recurrence of TART and persistent normal testicular function. In conclusion, mitotane should be used as a last resort in CAH patients in the cases of azoospermia associated with TARTs but normal inhibin B levels, as it can improve long-term endocrine and exocrine testicular function.
Fichier principal
Vignette du fichier
Bachelot et al. - 2021 - Effects of mitotane on testicular adrenal rest tum.pdf (268.09 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03121896 , version 1 (26-01-2021)

Identifiants

Citer

Anne Bachelot, Marion Lapoirie, Jerome Dulon, Monique Leban, Raphaele Renard Penna, et al.. Effects of mitotane on testicular adrenal rest tumors in congenital adrenal hyperplasia due to 21-hydroxylase deficiency - a retrospective series of five patients. European Journal of Endocrinology, 2021, ⟨10.1530/EJE-20-0787⟩. ⟨hal-03121896⟩
85 Consultations
93 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More