What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps? - Institut de Neurosciences des Systèmes Access content directly
Journal Articles Frontiers in Pharmacology Year : 2022

What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps?

Abstract

Medical use of cannabis has been receiving growing attention over the last few decades in modern medicine. As we know that the endocannabinoid system is largely involved in neurological disorders, we focused on the scientific rationale of medical cannabis in three neurological disorders: amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer’s disease through pharmacological plausibility, clinical studies, and patients’ view. Clinical studies (randomized controlled trials, open-label studies, cohorts, and case reports) exploring medical cannabis in these disorders show different results depending on the methods and outcomes. Some show benefits on motor symptoms and others on non-motor symptoms and quality of life. Concerning patients’ view, several web surveys were collected, highlighting the real use of cannabis to relieve symptoms of neurological disorders, mostly outside a medical pathway. This anarchic use keeps questioning particularly in terms of risks: consumption of street cannabis, drug–drug interactions with usual medical treatment, consideration of medical history, and adverse reactions (psychiatric, respiratory, cardiovascular disorders, etc.), underlining the importance of a medical supervision. To date, most scientific data support the therapeutic potential of cannabis in neurological disorders. As far as patients and patients’ associations are calling for it, there is an urgent need to manage clinical studies to provide stronger evidence and secure medical cannabis use.
Fichier principal
Vignette du fichier
fphar-13-883987.pdf (822.42 Ko) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-04100853 , version 1 (29-05-2024)

Identifiers

Cite

Clémence Lacroix, Isabelle Alleman-Brimault, Arnaud Zalta, Frank Rouby, Catherine Cassé-Perrot, et al.. What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps?. Frontiers in Pharmacology, 2022, 13, ⟨10.3389/fphar.2022.883987⟩. ⟨hal-04100853⟩
26 View
6 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More