Molecular dynamics simulations of microstructural evolution under irradiation of (U,Pu)O2 solid solutions have been carried out with the Frenkel pair accumulation method with two empirical potentials. Simulated X-Ray diffraction patterns have been systematically generated along the irradiation pathway from the computed atomistic configurations. Description of the X-Ray diffraction patterns with increasing irradiation dose is discussed. Attempt to correlate the features of the X-Ray diffraction peaks with the microstructural evolution is also provided. Special attention is dedicated to the swelling effect.