Journal Articles Annales d'Endocrinologie = Annals of Endocrinology Year : 2024

Diagnosis and management of children and adult craniopharyngiomas: a French Endocrine Society/French Society for Paediatric Endocrinology & Diabetes Consensus Statement

Thomas Cuny (1, 2, 3, 4) , Rachel Reynaud (1, 2, 5, 4) , Gérald Raverot (6) , Régis Coutant (7) , Philippe Chanson (8, 9, 10, 11) , Dulanjalee Kariyawasam (12, 13, 14) , Christine Poitou (15, 16) , Cécile Thomas-Teinturier (11, 10) , Bertrand Baussart (16) , Dinane Samara-Boustani (17) , Loïc Feuvret (16) , Carine Villanueva (6) , Chiara Villa (18) , Benjamin Bouillet (19, 20) , Maïthé Tauber (21, 22) , Stéphanie Espiard (23, 24) , Sarah Castets (5) , Albert Beckers (25, 26) , Jessica Amsellem (27) , Marie-Christine Vantyghem (23, 28, 29) , Brigitte Delemer (29) , Nicolas Chevalier (30) , Thierry Brue (1, 2, 3) , Nicolas André (31) , Thomas Graillon , Véronique Kerlan , Isabelle Raingeard , Claire Alapetite , Véronique Raverot , Sylvie Salenave , Anne Boulin , Romain Appay , Florian Dalmas , Sarah Fodil , Lucie Coppin , Camille Buffet , Philippe Thuillier , Frédéric Castinetti , Guillaume Vogin , Laure Cazabat , Emmanuelle Kuhn , Magalie Haissaguerre , Yves Reznik , Bernard Goichot , Anne Bachelot , Peter Kamenický (8, 10) , Bénédicte Decoudier , Charlotte Planchon , Jean-Arthur Micoulaud-Franchi , Pauline Romanet (1, 2, 32) , David Jacobi , Pauline Faucher , Claire Carette , Hélène Bihan , Delphine Drui , Sylvie Rossignol , Lucile Gonin , Emmanuelle Sokol , Laurent Wiard , Carine Courtillot , Marc Nicolino , Solange Grunenwald , Olivier Chabre , Sophie Christin-Maître (33, 34) , Rachel Desailloud (35, 36) , Dominique Maiter , Laurence Guignat , Aude Brac de la Perrière , Philippe Salva , Didier Scavarda , Fabrice Bonneville , Philippe Caron , Alexandre Vasiljevic , Christine Cortet , Stephan Gaillard , Frédérique Albarel , Karine Clément , Emmanuel Jouanneau , Henry Dufour , Pascal Barat , Blandine Gatta-Cherifi
1 MMG - Marseille medical genetics - Centre de génétique médicale de Marseille
2 MarMaRa - Institut Marseille Maladies Rares
3 Service d'endocrinologie, diabète, maladies métaboliques [Hôpital de la Conception - APHM]
4 HYPO - Centre de référence des maladies rares de l'hypophyse
5 Service de pédiatrie multidisciplinaire [Hôpital de la Timone Enfants - APHM]
6 HCL - Hospices Civils de Lyon
7 Endocrinologie pédiatrique[CHU Angers]
8 PHYSENDO - Physiologie et physiopathologie endocriniennes
9 AP-HP. Université Paris Saclay
10 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
11 Université Paris-Saclay
12 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
13 Hôpital Necker - Enfants Malades [AP-HP]
14 IC UM3 (UMR 8104 / U1016) - Institut Cochin
15 Nutriomics - Nutrition et obésités: approches systémiques (UMR-S 1269)
16 CHU Pitié-Salpêtrière [AP-HP]
17 Service d'endocrinologie, gynécologie et diabétologie pédiatriques [CHU Necker]
18 LJLL (UMR_7598) - Laboratoire Jacques-Louis Lions
19 Service d'Endocrinologie, Diabétologie et Maladies Métaboliques (CHU de Dijon)
20 LNC - Lipides - Nutrition - Cancer [Dijon - U1231]
21 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
22 Infinity - Institut Toulousain des Maladies Infectieuses et Inflammatoires
23 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
24 Université Lille Nord (France)
25 CHU-Liège - Centre Hospitalier Universitaire de Liège
26 Université de Liège
27 CHU Angers - Centre Hospitalier Universitaire d'Angers
28 Université de Lille
29 RTD - Recherche translationnelle sur le diabète - U 1190
30 C3M - Centre méditerranéen de médecine moléculaire
31 CRCM - Centre de Recherche en Cancérologie de Marseille
32 Laboratoire de Biochimie et de Biologie Moléculaire [Hôpital de la Conception - APHM]
33 CHU Saint-Antoine [AP-HP]
34 SU - Sorbonne Université
35 CHU Amiens-Picardie
36 PERITOX - Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV
Gérald Raverot
Thomas Graillon
  • Function : Author
Véronique Kerlan
  • Function : Author
Isabelle Raingeard
  • Function : Author
Claire Alapetite
  • Function : Author
Véronique Raverot
Sylvie Salenave
  • Function : Author
Anne Boulin
  • Function : Author
Romain Appay
  • Function : Author
Florian Dalmas
  • Function : Author
Sarah Fodil
  • Function : Author
Lucie Coppin
  • Function : Author
Camille Buffet
  • Function : Author
Philippe Thuillier
  • Function : Author
Frédéric Castinetti
  • Function : Author
Guillaume Vogin
  • Function : Author
Laure Cazabat
  • Function : Author
Emmanuelle Kuhn
  • Function : Author
Magalie Haissaguerre
  • Function : Author
Yves Reznik
  • Function : Author
Bernard Goichot
  • Function : Author
Anne Bachelot
  • Function : Author
Bénédicte Decoudier
  • Function : Author
Charlotte Planchon
  • Function : Author
Jean-Arthur Micoulaud-Franchi
  • Function : Author
David Jacobi
  • Function : Author
Pauline Faucher
  • Function : Author
Claire Carette
  • Function : Author
Hélène Bihan
  • Function : Author
Delphine Drui
  • Function : Author
Sylvie Rossignol
  • Function : Author
Lucile Gonin
  • Function : Author
Emmanuelle Sokol
  • Function : Author
Laurent Wiard
  • Function : Author
Carine Courtillot
  • Function : Author
Marc Nicolino
  • Function : Author
Solange Grunenwald
  • Function : Author
Olivier Chabre
  • Function : Author
Dominique Maiter
  • Function : Author
Laurence Guignat
  • Function : Author
Aude Brac de la Perrière
  • Function : Author
Philippe Salva
  • Function : Author
Didier Scavarda
  • Function : Author
Fabrice Bonneville
  • Function : Author
Philippe Caron
  • Function : Author
Alexandre Vasiljevic
  • Function : Author
Christine Cortet
  • Function : Author
Stephan Gaillard
Frédérique Albarel
  • Function : Author
Karine Clément
  • Function : Author
Emmanuel Jouanneau
Henry Dufour
  • Function : Author
Pascal Barat
  • Function : Author
Blandine Gatta-Cherifi
  • Function : Author

Abstract

Craniopharyngiomas are rare hypothalamic-pituitary tumors found in young children, adolescents and adults, and their multidisciplinary management required, calls for consistent practices for practicioners, patients and families. The French Endocrine Society and French Society for Pediatric Endocrinology & Diabetes enlisted and coordinated adult and paediatric endocrinologists, neurosurgeons, pathologists, radiotherapists as well as psychologists, dieticians and a patient association, to draft a reference document on this severe disease. The management of craniopharyngiomas remains complex due to their aggressive nature, invasive behavior, and propensity for recurrence, requiring a sequential and measured therapeutic approach and follow-up in expert centers. Although patient survival rates are high, the consequences of both the tumor and its treatment can lead to serious comorbidities and impaired quality of life, particularly in those patients with lesional hypothalamic syndrome. Recent advances have allowed the two described tumor types - papillary and adamantinomatous - to be associated with distinct molecular signatures, specific pathophysiological mechanisms and ipso facto, distinct therapeutic approaches, including innovative medications for hyperphagia, that will continue to evolve. This consensus statement covers all stages in the management of patients with craniopharyngioma, from diagnosis to therapeutic strategies including the long-term follow-up.
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Dates and versions

hal-04646201 , version 1 (18-07-2024)

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Thomas Cuny, Rachel Reynaud, Gérald Raverot, Régis Coutant, Philippe Chanson, et al.. Diagnosis and management of children and adult craniopharyngiomas: a French Endocrine Society/French Society for Paediatric Endocrinology & Diabetes Consensus Statement. Annales d'Endocrinologie = Annals of Endocrinology, 2024, ⟨10.1016/j.ando.2024.07.002⟩. ⟨hal-04646201⟩
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