R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways
Abstract
Using mice lacking the Wnt enhancer Rspo1, Lacour et al. demonstrate that Rspo1 controls muscle cell fusion during skeletal muscle regeneration. Rspo1-null muscle progenitor cells differentiate less efficiently but fuse extensively compared to wild-type cells. Rspo1 is shown to regulate the antagonism between canonical and non-canonical Wnt signaling pathways.
Domains
Life Sciences [q-bio]| Origin | Publication funded by an institution |
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