Detailed Contact Data and the Dissemination of Staphylococcus aureus in Hospitals

Abstract : Close proximity interactions (CPIs) measured by wireless electronic devices are increasingly used in epidemiological models. However, no evidence supports that electronically collected CPIs inform on the contacts leading to transmission. Here, we analyzed Staphylococcus aureus carriage and CPIs recorded simultaneously in a long-term care facility for 4 months in 329 patients and 261 healthcare workers to test this hypothesis. In the broad diversity of isolated S. aureus strains, 173 transmission events were observed between participants. The joint analysis of carriage and CPIs showed that CPI paths linking incident cases to other individuals carrying the same strain (i.e. possible infectors) had fewer intermediaries than predicted by chance (P < 0.001), a feature that simulations showed to be the signature of transmission along CPIs. Additional analyses revealed a higher dissemination risk between patients via healthcare workers than via other patients. In conclusion, S. aureus transmission was consistent with contacts defined by electronically collected CPIs, illustrating their potential as a tool to control hospital-acquired infections and help direct surveillance.
Document type :
Journal articles
Liste complète des métadonnées

Cited literature [38 references]  Display  Hide  Download

https://hal.sorbonne-universite.fr/hal-01134050
Contributor : Gestionnaire Hal-Upmc <>
Submitted on : Wednesday, February 10, 2016 - 3:30:14 PM
Last modification on : Wednesday, April 3, 2019 - 1:09:03 AM

File

journal.pcbi.1004170.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Thomas Obadia, Romain Silhol, Lulla Opatowski, Laura Temime, Judith Legrand, et al.. Detailed Contact Data and the Dissemination of Staphylococcus aureus in Hospitals. PLoS Computational Biology, Public Library of Science, 2015, 11 (3), pp.e1004170. ⟨10.1371/journal.pcbi.1004170⟩. ⟨hal-01134050v2⟩

Share

Metrics

Record views

784

Files downloads

966