A. Ferri, J. Sanes, M. Coleman, J. Cunningham, and A. Kato, Inhibiting Axon Degeneration and Synapse Loss Attenuates Apoptosis and Disease Progression in a Mouse Model of Motoneuron Disease, Current Biology, vol.13, issue.8, pp.669-673, 2003.
DOI : 10.1016/S0960-9822(03)00206-9

T. Gillingwater, C. Ingham, M. Coleman, and R. Ribchester, Ultrastructural correlates of synapse withdrawal at axotomized neuromuscular junctions in mutant and transgenic mice expressing the Wld gene, Journal of Anatomy, vol.203, issue.3, pp.265-276, 2003.
DOI : 10.1046/j.1469-7580.2003.00214.x

C. Sievers, N. Platt, V. Perry, M. Coleman, and L. Conforti, Neurites undergoing Wallerian degeneration show an apoptotic-like process with annexin V positive staining and loss of mitochondrial membrane potential, Neuroscience Research, vol.46, issue.2, pp.161-169, 2003.
DOI : 10.1016/S0168-0102(03)00039-7

N. Brose, O. Connor, V. Skehel, and P. , Synaptopathy: dysfunction of synaptic function?, Biochemical Society Transactions, vol.38, issue.2, pp.443-444, 2010.
DOI : 10.1042/BST0380443

A. Aguzzi, F. Baumann, and J. Bremer, The Prion's Elusive Reason for Being, Annual Review of Neuroscience, vol.31, issue.1, pp.439-477, 2008.
DOI : 10.1146/annurev.neuro.31.060407.125620

S. Brandner, S. Isenmann, A. Raeber, M. Fischer, and A. Sailer, Normal host prion protein necessary for scrapie-induced neurotoxicity, Nature, vol.379, issue.6563, pp.339-343, 1996.
DOI : 10.1038/379339a0

G. Mallucci, A. Dickinson, J. Linehan, P. Klohn, and S. Brandner, Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis, Science, vol.302, issue.5646, pp.871-874, 2003.
DOI : 10.1126/science.1090187

B. Chesebro, M. Trifilo, R. Race, K. Meade-white, and C. Teng, Anchorless Prion Protein Results in Infectious Amyloid Disease Without Clinical Scrapie, Science, vol.308, issue.5727, pp.1435-1439, 2005.
DOI : 10.1126/science.1110837

D. Harris and H. True, New Insights into Prion Structure and Toxicity, Neuron, vol.50, issue.3, pp.353-357, 2006.
DOI : 10.1016/j.neuron.2006.04.020

K. Winklhofer, J. Tatzelt, and C. Haass, The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases, The EMBO Journal, vol.279, issue.2, pp.336-349, 2008.
DOI : 10.1038/sj.emboj.7601930

A. Rambold, V. Muller, R. U. Ben-tal, N. Winklhofer, and K. , Stress-protective signalling of prion protein is corrupted by scrapie prions, The EMBO Journal, vol.27, issue.14, p.18566584, 1919.
DOI : 10.1038/emboj.2008.122

B. Schneider, M. Pietri, E. Pradines, D. Loubet, and J. Launay, Understanding the neurospecificity of Prion protein signaling, Frontiers in Bioscience, vol.16, issue.1, pp.169-186, 2011.
DOI : 10.2741/3682

R. Linden, V. Martins, M. Prado, M. Cammarota, and I. Izquierdo, Physiology of the Prion Protein, Physiological Reviews, vol.88, issue.2, pp.673-728, 2008.
DOI : 10.1152/physrev.00007.2007

A. Alleaume-butaux, C. Dakowski, M. Pietri, S. Mouillet-richard, and J. Launay, Cellular prion protein is required for neuritogenesis: fine-tuning of multiple singaling pathways involved in focal adhesions and actin cytoskeleton dynamics, Cell Health and Cytoskeleton, vol.5, pp.1-12, 2013.

D. Loubet, C. Dakowski, M. Pietri, E. Pradines, and S. Bernard, Neuritogenesis: the prion protein controls ??1 integrin signaling activity, The FASEB Journal, vol.26, issue.2, p.22038049, 2012.
DOI : 10.1096/fj.11-185579

E. Graner, A. Mercadante, S. Zanata, O. Forlenza, and A. Cabral, Cellular prion protein binds laminin and mediates neuritogenesis, Molecular Brain Research, vol.76, issue.1, pp.85-92, 2000.
DOI : 10.1016/S0169-328X(99)00334-4

A. Santuccione, V. Sytnyk, I. Leshchyns-'ka, and M. Schachner, and to enhance neurite outgrowth, The Journal of Cell Biology, vol.71, issue.2, pp.341-354, 2005.
DOI : 10.1093/bmb/66.1.43

M. Lopes, G. Hajj, A. Muras, G. Mancini, and R. Castro, Interaction of Cellular Prion and Stress-Inducible Protein 1 Promotes Neuritogenesis and Neuroprotection by Distinct Signaling Pathways, Journal of Neuroscience, vol.25, issue.49, pp.11330-11339, 2005.
DOI : 10.1523/JNEUROSCI.2313-05.2005

G. Hajj, T. Santos, Z. Cook, and V. Martins, Developmental expression of prion protein and its ligands stress-inducible protein 1 and vitronectin, The Journal of Comparative Neurology, vol.21, issue.3, pp.371-384, 2009.
DOI : 10.1002/cne.22157

F. Beraldo, C. Arantes, T. Santos, N. Queiroz, and K. Young, Role of ??7 Nicotinic Acetylcholine Receptor in Calcium Signaling Induced by Prion Protein Interaction with Stress-inducible Protein 1, Journal of Biological Chemistry, vol.285, issue.47, pp.36542-36550, 2010.
DOI : 10.1074/jbc.M110.157263

F. Beraldo, C. Arantes, T. Santos, C. Machado, and M. Roffe, Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin ??1 chain, The FASEB Journal, vol.25, issue.1, pp.265-279, 2011.
DOI : 10.1096/fj.10-161653

S. Mouillet-richard, V. Mutel, S. Loric, C. Tournois, and J. Launay, Regulation by Neurotransmitter Receptors of Serotonergic or Catecholaminergic Neuronal Cell Differentiation, Journal of Biological Chemistry, vol.275, issue.13, pp.9186-9192, 2000.
DOI : 10.1074/jbc.275.13.9186

S. Mouillet-richard, N. Nishida, E. Pradines, H. Laude, and B. Schneider, Prions Impair Bioaminergic Functions through Serotonin- or Catecholamine-derived Neurotoxins in Neuronal Cells, Journal of Biological Chemistry, vol.283, issue.35, pp.23782-23790, 2008.
DOI : 10.1074/jbc.M802433200
URL : https://hal.archives-ouvertes.fr/hal-00331728

M. Pietri, C. Dakowski, S. Hannaoui, A. Alleaume-butaux, and J. Hernandez-rapp, PDK1 decreases TACE-mediated ??-secretase activity and promotes disease progression in prion and Alzheimer's diseases, Nature Medicine, vol.38, issue.9, pp.1124-1131, 2013.
DOI : 10.4155/bio.09.185

S. Paquet, C. Langevin, J. Chapuis, G. Jackson, and H. Laude, Efficient dissemination of prions through preferential transmission to nearby cells, Journal of General Virology, vol.88, issue.2, pp.706-713, 2007.
DOI : 10.1099/vir.0.82336-0

O. Bernard, Lim kinases, regulators of actin dynamics, The International Journal of Biochemistry & Cell Biology, vol.39, issue.6, pp.1071-1076, 2007.
DOI : 10.1016/j.biocel.2006.11.011

M. Endo, K. Ohashi, Y. Sasaki, Y. Goshima, and R. Niwa, Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin, J Neurosci, vol.23, pp.2527-2537, 2003.

J. Ng and L. Luo, Rho GTPases Regulate Axon Growth through Convergent and Divergent Signaling Pathways, Neuron, vol.44, issue.5, pp.779-793, 2004.
DOI : 10.1016/j.neuron.2004.11.014

K. Riento and A. Ridley, Rocks: multifunctional kinases in cell behaviour, Nature Reviews Molecular Cell Biology, vol.4, issue.6, pp.446-456, 2003.
DOI : 10.1038/nrm1128

B. Mueller, H. Mack, and N. Teusch, Rho kinase, a promising drug target for neurological disorders, Nature Reviews Drug Discovery, vol.128, issue.5, pp.387-398, 2005.
DOI : 10.1046/j.1523-1755.2002.00328.x

M. Olson, Applications for ROCK kinase inhibition, Current Opinion in Cell Biology, vol.20, issue.2, pp.242-248, 2008.
DOI : 10.1016/j.ceb.2008.01.002

T. Stankiewicz and D. Linseman, Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration, Frontiers in Cellular Neuroscience, vol.302, issue.e12606, p.25339865, 2014.
DOI : 10.1126/science.1090154

J. Launay, B. Schneider, S. Loric, D. Prada, M. Kellermann et al., Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells, The FASEB Journal, vol.20, issue.11, pp.1843-1854, 2006.
DOI : 10.1096/fj.06-5724com

J. Peyrin, B. Deleglise, L. Saias, M. Vignes, and P. Gougis, Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers, Lab on a Chip, vol.76, issue.21, pp.3663-3673, 2011.
DOI : 10.1039/c1lc20014c

B. Deleglise, B. Lassus, V. Soubeyre, A. Alleaume-butaux, and J. Hjorth, Synapto-Protective Drugs Evaluation in Reconstructed Neuronal Network, PLoS ONE, vol.8, issue.8, p.23976987, 2013.
DOI : 10.1371/journal.pone.0071103.s001
URL : https://hal.archives-ouvertes.fr/hal-01221378

B. Deleglise, S. Magnifico, E. Duplus, P. Vaur, and V. Soubeyre, 2014) ss-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network, Acta Neuropathol Commun, vol.2, pp.145-25253021

S. Cronier, H. Laude, and J. Peyrin, Prions can infect primary cultured neurons and astrocytes and promote neuronal cell death, Proceedings of the National Academy of Sciences, vol.101, issue.33, pp.12271-12276, 2004.
DOI : 10.1073/pnas.0402725101

S. Cronier, V. Beringue, A. Bellon, J. Peyrin, and H. Laude, Prion Strain- and Species-Dependent Effects of Antiprion Molecules in Primary Neuronal Cultures, Journal of Virology, vol.81, issue.24, pp.13794-13800, 2007.
DOI : 10.1128/JVI.01502-07

L. Westergard, J. Turnbaugh, and D. Harris, A Naturally Occurring C-terminal Fragment of the Prion Protein (PrP) Delays Disease and Acts as a Dominant-negative Inhibitor of PrPSc Formation, Journal of Biological Chemistry, vol.286, issue.51, pp.44234-44242, 2011.
DOI : 10.1074/jbc.M111.286195

S. Mouillet-richard, M. Ermonval, C. Chebassier, J. Laplanche, and S. Lehmann, Signal Transduction Through Prion Protein, Science, vol.289, issue.5486, pp.1925-1928, 2000.
DOI : 10.1126/science.289.5486.1925

V. Calleja, M. Laguerre, G. De-las-heras-martinez, P. Parker, and J. Requejo-isidro, Acute regulation of PDK1 by a complex interplay of molecular switches, Biochemical Society Transactions, vol.4, issue.5, pp.1435-1440, 2014.
DOI : 10.1016/j.lfs.2013.09.007

X. Gao and T. Harris, Role of the PH domain in regulating in vitro autophosphorylation events required for reconstitution of PDK1 catalytic activity, Bioorganic Chemistry, vol.34, issue.4, pp.200-223, 2006.
DOI : 10.1016/j.bioorg.2006.05.002

Y. Li, K. Yang, and J. Park, Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer, World Journal of Biological Chemistry, vol.1, issue.8, pp.239-247, 2010.
DOI : 10.4331/wjbc.v1.i8.239

C. Vidal, C. Herzog, A. Haeberle, C. Bombarde, and M. Miquel, Early dysfunction of central 5-HT system in a murine model of bovine spongiform encephalopathy, Neuroscience, vol.160, issue.4, pp.731-743, 2009.
DOI : 10.1016/j.neuroscience.2009.02.072

D. Silva, J. Medina, M. Zuliani, C. , D. Nardo et al., RhoA/ROCK regulation of neuritogenesis via profilin IIa???mediated control of actin stability, The Journal of Cell Biology, vol.120, issue.7, pp.1267-1279, 2003.
DOI : 10.1016/S0896-6273(00)81114-9

C. Bramham, Control of synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implications, Prog Brain Res, vol.163, pp.453-471, 2007.
DOI : 10.1016/S0079-6123(07)63025-8

S. Kim and P. Coulombe, Emerging role for the cytoskeleton as an organizer and regulator of translation, Nature Reviews Molecular Cell Biology, vol.356, issue.1, pp.75-81, 2010.
DOI : 10.1038/nrm2818

H. Jung, B. Yoon, and C. Holt, Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair, Nat Rev Neurosci, vol.13, pp.308-324, 2012.

J. Howe and J. Hershey, Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells, Cell, vol.37, issue.1, pp.85-93, 1984.
DOI : 10.1016/0092-8674(84)90303-9

J. Heuijerjans, F. Pieper, F. Ramaekers, L. Timmermans, and H. Kuijpers, Association of mRNA and eIF-2?? with the cytoskeleton in cells lacking vimentin, Experimental Cell Research, vol.181, issue.2, pp.317-330, 1989.
DOI : 10.1016/0014-4827(89)90091-8

A. Baudry, S. Mouillet-richard, B. Schneider, J. Launay, and O. Kellermann, MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants, Science, vol.329, issue.5998, pp.1537-1541, 2010.
DOI : 10.1126/science.1193692

J. Moreno, H. Radford, D. Peretti, J. Steinert, and N. Verity, Sustained translational repression by eIF2alpha-P mediates prion neurodegeneration, Nature, vol.485, pp.507-511, 2012.

C. Gibson, K. Srivastava, N. Sprigg, P. Bath, and U. Bayraktutan, Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions, Journal of Neurochemistry, vol.594, issue.5, pp.816-826, 2014.
DOI : 10.1111/jnc.12681

R. Guo, B. Liu, S. Zhou, B. Zhang, and Y. Xu, The Protective Effect of Fasudil on the Structure and Function of Cardiac Mitochondria from Rats with Type 2 Diabetes Induced by Streptozotocin with a High-Fat Diet Is Mediated by the Attenuation of Oxidative Stress, BioMed Research International, vol.38, issue.10, p.23762845, 2013.
DOI : 10.1161/01.RES.0000096650.91688.28

Y. Zhou, Y. Su, B. Li, F. Liu, and J. Ryder, Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic A??42 by Inhibiting Rho, Science, vol.302, issue.5648, pp.1215-1217, 2003.
DOI : 10.1126/science.1090154

A. Rodriguez-perez, A. Dominguez-meijide, J. Lanciego, M. Guerra, and J. Labandeira-garcia, Inhibition of Rho kinase mediates the neuroprotective effects of estrogen in the MPTP model of Parkinson's disease, Neurobiology of Disease, vol.58, p.23774254, 2013.
DOI : 10.1016/j.nbd.2013.06.004

J. Labandeira-garcia, A. Rodriguez-perez, B. Villar-cheda, A. Borrajo, and A. Dominguez-meijide, Rho Kinase and Dopaminergic Degeneration, The Neuroscientist, vol.48, issue.6, 2014.
DOI : 10.1371/journal.pone.0045499

J. Herskowitz, Y. Feng, A. Mattheyses, C. Hales, and L. Higginbotham, Pharmacologic inhibition of ROCK2 suppresses amyloid-beta production in an Alzheimer's disease mouse model, J Neurosci, vol.33, p.24305806, 2013.

M. Pietri, A. Caprini, S. Mouillet-richard, E. Pradines, and M. Ermonval, Overstimulation of PrPC Signaling Pathways by Prion Peptide 106-126 Causes Oxidative Injury of Bioaminergic Neuronal Cells, Journal of Biological Chemistry, vol.281, issue.38, pp.28470-28479, 2006.
DOI : 10.1074/jbc.M602774200

M. Lenter, H. Uhlig, A. Hamann, P. Jeno, and B. Imhof, A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1., Proceedings of the National Academy of Sciences, vol.90, issue.19, pp.9051-9055, 1993.
DOI : 10.1073/pnas.90.19.9051

S. Kempster, C. Bate, and A. Williams, Simvastatin treatment prolongs the survival of scrapie-infected mice, NeuroReport, vol.18, issue.5, pp.479-482, 2007.
DOI : 10.1097/WNR.0b013e328058678d

A. Mccabe, M. Dolled-filhart, R. Camp, and D. Rimm, Automated Quantitative Analysis (AQUA) of In Situ Protein Expression, Antibody Concentration, and Prognosis, JNCI Journal of the National Cancer Institute, vol.97, issue.24, pp.1808-1815, 2005.
DOI : 10.1093/jnci/dji427

C. Bate, J. Langeveld, and A. Williams, Manipulation of PrPres production in scrapie-infected neuroblastoma cells, Journal of Neuroscience Methods, vol.138, issue.1-2, pp.217-223, 2004.
DOI : 10.1016/j.jneumeth.2004.04.001

A. Hofler, T. Nichols, S. Grant, L. Lingardo, and E. Esposito, Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays, Analytical Biochemistry, vol.414, issue.2, pp.179-186, 2011.
DOI : 10.1016/j.ab.2011.03.013

D. Moore and B. Sefton, Analysis of protein phosphorylation, Current Protocols in Molecular Biology, 1997.

D. Alessi, M. Deak, A. Casamayor, F. Caudwell, and N. Morrice, 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase, Current Biology, vol.7, issue.10, pp.776-789, 1997.
DOI : 10.1016/S0960-9822(06)00336-8

D. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, and N. Morrice, Mechanism of activation of protein kinase B by insulin and IGF-1, Embo J, vol.15, pp.6541-6551, 1996.

R. Yadavalli, R. Guttmann, T. Seward, A. Centers, and R. Williamson, Modulates Scrapie Prion Propagation, Journal of Biological Chemistry, vol.279, issue.21, pp.21948-56, 2004.
DOI : 10.1074/jbc.M400793200

C. Mays, C. Kim, T. Haldiman, J. Van-der-merwe, and A. Lau, Prion disease tempo determined by host-dependent substrate reduction, Journal of Clinical Investigation, vol.124, issue.2, pp.847-58, 2014.
DOI : 10.1172/JCI72241DS1