. Apoa-i, A. Apolipoprotein, and . Apob, Apolipoprotein B; hs-CRP, High sensitive C-reactive protein; HOMA-IR, Homeostatic model assessment-insulin resistance References 1. Turchinovich A, Weiz L, Langheinz A, Burwinkel B. Characterization of extracellular circulating microRNA, Nucleic Acids Res, vol.39, pp.7223-7256, 2011.

M. Mayr, A. Zampetaki, P. Willeit, J. Willeit, and S. Kiechl, MicroRNAs Within the Continuum of Postgenomics Biomarker Discovery, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.33, issue.2, pp.206-220, 2013.
DOI : 10.1161/ATVBAHA.112.300141

T. Lawrence and D. Gilroy, Chronic inflammation: a failure of resolution?, International Journal of Experimental Pathology, vol.15, issue.69, pp.85-94, 2007.
DOI : 10.1111/j.1365-2613.2006.00507.x

K. Moore, F. Sheedy, and E. Fisher, Macrophages in atherosclerosis: a dynamic balance, Nature Reviews Immunology, vol.92, issue.10, pp.709-730, 2013.
DOI : 10.1038/nri3520

E. Gautier, T. Huby, J. Witztum, B. Ouzilleau, E. Miller et al., Macrophage Apoptosis Exerts Divergent Effects on Atherogenesis as a Function of Lesion Stage, Circulation, vol.119, issue.13, pp.1795-804, 2009.
DOI : 10.1161/CIRCULATIONAHA.108.806158

A. Shearn, V. Deswaerte, E. Gautier, F. Saint-charles, J. Pirault et al., Bcl-x Inactivation in Macrophages Accelerates Progression of Advanced Atherosclerotic Lesions in Apoe-/- Mice, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.32, issue.5, pp.1142-1151, 2012.
DOI : 10.1161/ATVBAHA.111.239111

T. Seimon and I. Tabas, Mechanisms and consequences of macrophage apoptosis in atherosclerosis, The Journal of Lipid Research, vol.50, issue.Supplement, pp.382-389, 2009.
DOI : 10.1194/jlr.R800032-JLR200

K. Moore and I. Tabas, Macrophages in the Pathogenesis of Atherosclerosis, Cell, vol.145, issue.3, pp.341-55, 2011.
DOI : 10.1016/j.cell.2011.04.005

K. Paulson, S. Zhu, M. Chen, S. Nurmohamed, J. Jongstra-bilen et al., Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis, Circulation Research, vol.106, issue.2, pp.383-90, 2010.
DOI : 10.1161/CIRCRESAHA.109.210781

S. Halim and L. Newby, Prognostic Biomarkers in Individuals with Prevalent Coronary Heart Disease, Disease Markers, vol.26, issue.5-6, pp.265-71, 2009.
DOI : 10.1155/2009/854193

URL : http://doi.org/10.1155/2009/854193

C. Baigent, L. Blackwell, J. Emberson, L. Holland, C. Reith et al., Efficacy and safety of more intensive lowering of LDL cholesterol: a metaanalysis of data from 170,000 participants in 26 randomised trials, Lancet, vol.376, pp.1670-81, 2010.

M. Ritchie, B. Phipson, D. Wu, Y. Hu, C. Law et al., limma powers differential expression analyses for RNA-sequencing and microarray studies, Nucleic Acids Research, vol.43, issue.7, p.47, 2015.
DOI : 10.1093/nar/gkv007

C. Law, Y. Chen, W. Shi, and G. Smyth, voom: precision weights unlock linear model analysis tools for RNA-seq read counts, Genome Biology, vol.15, issue.2, p.29, 2014.
DOI : 10.1186/gb-2004-5-10-r80

Y. Benjamini and Y. Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, J R Stat Soc B, vol.57, pp.289-300, 1995.

T. Ruggiero, M. Trabucchi, D. Santa, F. Zupo, S. Harfe et al., LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages, The FASEB Journal, vol.23, issue.9, pp.2898-908, 2009.
DOI : 10.1096/fj.09-131342

A. Jacquel, S. Obba, L. Boyer, M. Dufies, G. Robert et al., Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions, Blood, vol.119, issue.19, pp.4527-4558, 2012.
DOI : 10.1182/blood-2011-11-392167

P. Bianchi, O. Kunduzova, E. Masini, C. Cambon, D. Bani et al., Oxidative Stress by Monoamine Oxidase Mediates Receptor-Independent Cardiomyocyte Apoptosis by Serotonin and Postischemic Myocardial Injury, Circulation, vol.112, issue.21, pp.3297-305, 2005.
DOI : 10.1161/CIRCULATIONAHA.104.528133

C. Chen, D. Ridzon, A. Broomer, Z. Zhou, D. Lee et al., Real-time quantification of microRNAs by stem-loop RT-PCR, Nucleic Acids Research, vol.33, issue.20, p.179, 2005.
DOI : 10.1093/nar/gni178

M. Kirschner, S. Kao, J. Edelman, N. Armstrong, M. Vallely et al., Haemolysis during Sample Preparation Alters microRNA Content of Plasma, PLoS ONE, vol.105, issue.9, p.24145, 2011.
DOI : 10.1371/journal.pone.0024145.s003

J. Ren, J. Zhang, N. Xu, G. Han, Q. Geng et al., Signature of Circulating MicroRNAs as Potential Biomarkers in Vulnerable Coronary Artery Disease, PLoS ONE, vol.105, issue.12, p.80738, 2013.
DOI : 10.1371/journal.pone.0080738.s003

A. Torres, K. Torres, P. Wdowiak, T. Paszkowski, and R. Maciejewski, Selection and validation of endogenous controls for microRNA expression studies in endometrioid endometrial cancer tissues, Gynecologic Oncology, vol.130, issue.3, pp.588-94, 2013.
DOI : 10.1016/j.ygyno.2013.06.026

F. Bouisset, V. Bongard, J. Ruidavets, S. Hascoet, D. Taraszkiewicz et al., Prognostic Usefulness of Clinical and Subclinical Peripheral Arterial Disease in Men With Stable Coronary Heart Disease, The American Journal of Cardiology, vol.110, issue.2, pp.197-202, 2012.
DOI : 10.1016/j.amjcard.2012.03.013

A. Genoux, V. Pons, C. Radojkovic, F. Roux-dalvai, G. Combes et al., Mitochondrial Inhibitory Factor 1 (IF1) Is Present in Human Serum and Is Positively Correlated with HDL-Cholesterol, PLoS ONE, vol.581, issue.9, p.23949, 2011.
DOI : 10.1371/journal.pone.0023949.t001

J. Roeykens, R. Rogers, R. Meeusen, L. Magnus, J. Borms et al., Validity and reliability in a Flemish population of the WHO-MONICA Optional Study of Physical Activity Questionnaire, Medicine & Science in Sports & Exercise, vol.30, issue.7, pp.1071-1076, 1998.
DOI : 10.1097/00005768-199807000-00008

H. Resnick, R. Lindsay, M. Mcdermott, R. Devereux, K. Jones et al., Relationship of High and Low Ankle Brachial Index to All-Cause and Cardiovascular Disease Mortality: The Strong Heart Study, Circulation, vol.109, issue.6, pp.733-742, 2004.
DOI : 10.1161/01.CIR.0000112642.63927.54

W. Friedewald, R. Levy, and D. Fredrickson, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin Chem, vol.18, pp.499-502, 1972.

F. Harrell-jr, K. Lee, and D. Mark, MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS, Statistics in Medicine, vol.15, issue.4, pp.361-87, 1996.
DOI : 10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4

E. Delong, D. Delong, and D. Clarke-pearson, Comparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach, Biometrics, vol.44, issue.3, pp.837-882, 1988.
DOI : 10.2307/2531595

A. Verhagen and G. Pruijn, Are the Ro RNP-associated Y RNAs concealing microRNAs? Y RNA-derived miRNAs may be involved in autoimmunity, BioEssays, vol.39, issue.9, pp.674-82, 2011.
DOI : 10.1002/bies.201100048

J. Perreault, J. Noel, F. Briere, B. Cousineau, J. Lucier et al., Retropseudogenes derived from the human Ro/SS-A autoantigen-associated hY RNAs, Nucleic Acids Research, vol.33, issue.6, pp.2032-2073, 2005.
DOI : 10.1093/nar/gki504

J. Dhahbi, S. Spindler, H. Atamna, D. Boffelli, P. Mote et al., 5'-YRNA fragments derived by processing of transcripts from specific YRNA genes and pseudogenes are abundant in human serum and plasma, Physiological Genomics, vol.45, issue.21, pp.990-998, 2013.
DOI : 10.1152/physiolgenomics.00129.2013

D. Schotte, J. Chau, G. Sylvester, G. Liu, C. Chen et al., Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia, Leukemia, vol.16, issue.2, pp.313-335, 2009.
DOI : 10.1038/leu.2008.286

F. Nicolas, A. Hall, T. Csorba, C. Turnbull, and T. Dalmay, Biogenesis of Y RNA-derived small RNAs is independent of the microRNA pathway, FEBS Letters, vol.20, issue.8, pp.1226-1256, 2012.
DOI : 10.1016/j.febslet.2012.03.026

E. Repetto, P. Briata, N. Kuziner, B. Harfe, M. Mcmanus et al., Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP, PLoS Genet, vol.8, 2012.

J. Dhahbi, S. Spindler, H. Atamna, D. Boffelli, and D. Martin, Deep Sequencing of Serum Small RNAs Identifies Patterns of 5&#39; tRNA Half and YRNA Fragment Expression Associated with Breast Cancer, Biomarkers in Cancer, vol.6, pp.37-47, 2014.
DOI : 10.4137/BIC.S20764

J. Rong, M. Shapiro, E. Trogan, and E. Fisher, Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading, Proceedings of the National Academy of Sciences, vol.100, issue.23, pp.13531-13537, 2003.
DOI : 10.1073/pnas.1735526100

J. Dhahbi, Circulating small noncoding RNAs as biomarkers of aging, Ageing Research Reviews, vol.17, pp.86-98, 2014.
DOI : 10.1016/j.arr.2014.02.005

K. Vickers and A. Remaley, Lipid-based carriers of microRNAs and intercellular communication, Current Opinion in Lipidology, vol.23, issue.2, pp.91-98, 2012.
DOI : 10.1097/MOL.0b013e328350a425

R. Gerszten and T. Wang, The search for new cardiovascular biomarkers, Nature, vol.112, issue.7181, pp.949-52, 2008.
DOI : 10.1038/nature06802

A. Zampetaki, P. Willeit, I. Drozdov, S. Kiechl, and M. Mayr, Profiling of circulating microRNAs: from single biomarkers to re-wired networks, Cardiovascular Research, vol.93, issue.4, pp.555-62, 2012.
DOI : 10.1093/cvr/cvr266

S. Engelhardt and R. Small, Small RNA Biomarkers Come of Age??????Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology., Journal of the American College of Cardiology, vol.60, issue.4, pp.300-303, 2012.
DOI : 10.1016/j.jacc.2012.04.018

G. Expression and O. , Small RNA-sequencing in apoptotic macrophages, 2015.

T. Seimon, M. Nadolski, X. Liao, J. Magallon, M. Nguyen et al., Atherogenic Lipids and Lipoproteins Trigger CD36-TLR2-Dependent Apoptosis in Macrophages Undergoing Endoplasmic Reticulum Stress, Cell Metabolism, vol.12, issue.5, pp.467-82, 2010.
DOI : 10.1016/j.cmet.2010.09.010