A. Corbett, J. Pickett, A. Burns, J. Corcoran, S. Dunnett et al., Drug repositioning for Alzheimer's disease, Nature Reviews Drug Discovery, vol.32, issue.11, pp.833-846, 2012.
DOI : 10.1038/nrd3869

M. Albert, S. Dekosky, D. Dickson, B. Dubois, H. Feldman et al., The diagnosis of mild cognitive impairment due to Alzheimer???s disease: Recommendations from the National Institute on Aging-Alzheimer???s Association workgroups on diagnostic guidelines for Alzheimer's disease, Alzheimer's & Dementia, vol.7, issue.3, pp.270-279, 2011.
DOI : 10.1016/j.jalz.2011.03.008

C. Duyckaerts, B. Delatour, and M. Potier, Classification and basic pathology of Alzheimer disease, Acta Neuropathologica, vol.14, issue.2, pp.5-36, 2009.
DOI : 10.1007/s00401-009-0532-1

R. Bateman, C. Xiong, T. Benzinger, A. Fagan, A. Goate et al., Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease, New England Journal of Medicine, vol.367, issue.9, pp.795-804, 2012.
DOI : 10.1056/NEJMoa1202753

M. Jucker and L. Walker, Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders, Annals of Neurology, vol.270, issue.suppl 1, pp.532-540, 2011.
DOI : 10.1002/ana.22615

A. Barnett, J. Berman, S. Li, J. Quarless, S. Bursztajn et al., Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system, Neuron, vol.14, pp.671-680, 1995.

A. Cataldo, J. Barnett, C. Pieroni, and R. Nixon, Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis

A. Petanceska, S. Terio, N. Peterhoff, C. Durham, R. Mercken et al., Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome, Neurobiol Aging, vol.25, pp.1263-1272, 2004.

A. Peterhoff, C. Troncoso, J. Gomez-isla, T. Hyman, B. Nixon et al., Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations, Am J Pathol, vol.157, pp.277-286, 2000.

A. Cataldo, G. Rebeck, B. Ghetri, C. Hulette, C. Lippa et al., Endocytic disturbances distinguish among subtypes of alzheimer's disease and related disorders, Annals of Neurology, vol.53, issue.5, pp.661-665, 2001.
DOI : 10.1002/ana.1254

A. Coppus, M. Schuur, J. Vergeer, A. Janssens, B. Oostra et al., Plasma ?? amyloid and the risk of Alzheimer's disease in Down syndrome, Neurobiology of Aging, vol.33, issue.9, pp.1988-1994, 2012.
DOI : 10.1016/j.neurobiolaging.2011.08.007

A. Cataldo, P. Mathews, A. Boiteau, L. Hassinger, C. Peterhoff et al., Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology, The American Journal of Pathology, vol.173, issue.2, pp.370-384, 2008.
DOI : 10.2353/ajpath.2008.071053

J. Cossec, J. Lavaur, D. Berman, I. Rivals, A. Hoischen et al., Trisomy for Synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes, Human Molecular Genetics, vol.21, issue.14, pp.3156-3172, 2012.
DOI : 10.1093/hmg/dds142

J. Lambert, S. Heath, G. Even, D. Campion, K. Sleegers et al., Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease, Nature Genetics, vol.12, issue.10, pp.1094-1099, 2009.
DOI : 10.1038/ng.439

A. Armstrong, N. Mattsson, H. Appelqvist, C. Janefjord, L. Sandin et al., Lysosomal Network Proteins as Potential Novel CSF Biomarkers for Alzheimer???s Disease, NeuroMolecular Medicine, vol.7, issue.1, pp.150-160, 2014.
DOI : 10.1007/s12017-013-8269-3

L. Koric, O. Felician, and M. Ceccaldi, Utilisation des biomarqueurs du LCR dans le diagnostic de la maladie d???Alzheimer en pratique clinique, Revue Neurologique, vol.167, issue.6-7, pp.474-484, 2011.
DOI : 10.1016/j.neurol.2010.10.007

L. Souza, F. Corlier, M. Habert, O. Uspenskaya, R. Maroy et al., Similar beta-amyloid burden in posterior cortical atrophy and Alzheimer's disease, Alzheimer's & Dementia, vol.7, issue.4, pp.2036-2043, 2011.
DOI : 10.1016/j.jalz.2011.05.919

L. Souza, F. Lamari, S. Belliard, C. Jardel, C. Houillier et al., Cerebrospinal fluid biomarkers in the differential diagnosis of Alzheimer's disease from other cortical dementias, Journal of Neurology, Neurosurgery & Psychiatry, vol.82, issue.3, pp.240-246, 2011.
DOI : 10.1136/jnnp.2010.207183

J. Olivo-marin, Extraction of spots in biological images using multiscale products, Pattern Recognition, vol.35, issue.9, pp.1989-1996, 2002.
DOI : 10.1016/S0031-3203(01)00127-3

F. Chaumont, S. Dallongeville, N. Chenouard, N. Herve, S. Pop et al., Icy: an open bioimage informatics platform for extended reproducible research, Nature Methods, vol.9, issue.7, pp.690-696, 2012.
DOI : 10.1038/nmeth.2075

C. Rowe, S. Ng, U. Ackermann, S. Gong, K. Pike et al., Imaging ??-amyloid burden in aging and dementia, Neurology, vol.68, issue.20, pp.1718-1725, 2007.
DOI : 10.1212/01.wnl.0000261919.22630.ea

H. Snyder, M. Carrillo, F. Grodstein, K. Henriksen, A. Jeromin et al., Developing novel blood-based biomarkers for Alzheimer's disease, Alzheimer's & Dementia, vol.10, issue.1, pp.109-114, 2014.
DOI : 10.1016/j.jalz.2013.10.007

C. Karch and A. Goate, Alzheimer???s Disease Risk Genes and Mechanisms of Disease Pathogenesis, Biological Psychiatry, vol.77, issue.1, pp.43-51, 2015.
DOI : 10.1016/j.biopsych.2014.05.006

Y. Jiang, K. Mullaney, C. Peterhoff, C. S. Schmidt, S. Boyer-boiteau et al., Alzheimer's-related endosome dysfunction in Down syndrome is A??-independent but requires APP and is reversed by BACE-1 inhibition, Proceedings of the National Academy of Sciences, vol.107, issue.4, pp.1630-1635, 2009.
DOI : 10.1073/pnas.0908953107

E. Martinez-morillo, O. Hansson, Y. Atagi, G. Bu, L. Minthon et al., Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer???s disease patients and controls, Acta Neuropathologica, vol.70, issue.Suppl, pp.633-643, 2014.
DOI : 10.1007/s00401-014-1266-2

R. Zimmermann, E. Huber, C. Schamber, N. Lelental, B. Mroczko et al., Plasma concentrations of the amyloid-beta peptides in young volunteers: the influence of the APOE genotype, J Alzheimers Dis, vol.40, pp.1055-1060, 2014.

S. Swaminathan, S. Risacher, K. Yoder, J. West, L. Shen et al., Association of plasma and cortical amyloid beta is modulated by APOE ??4 status, Alzheimer's & Dementia, vol.10, issue.1, pp.9-18, 2014.
DOI : 10.1016/j.jalz.2013.01.007

J. Zaghi, B. Goldenson, M. Inayathullah, A. Lossinsky, A. Masoumi et al., Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy, Acta Neuropathologica, vol.10, issue.2, pp.111-124, 2009.
DOI : 10.1007/s00401-008-0481-0

A. Rembach, A. Watt, W. Wilson, S. Rainey-smith, K. Ellis et al., An increased neutrophil???lymphocyte ratio in Alzheimer's disease is a function of age and is weakly correlated with neocortical amyloid accumulation, Journal of Neuroimmunology, vol.273, issue.1-2, pp.65-71, 2014.
DOI : 10.1016/j.jneuroim.2014.05.005

J. Cossec, C. Marquer, M. Panchal, A. Lazar, C. Duyckaerts et al., Cholesterol changes in Alzheimer's disease: methods of analysis and impact on the formation of enlarged endosomes, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1801, issue.8, pp.839-845, 2010.
DOI : 10.1016/j.bbalip.2010.03.010

J. , S. A. Marquer, C. Moldrich, R. Leterrier, C. Rossier et al., Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol, Biochim Biophys Acta, vol.1801, pp.846-852, 2010.

C. Marquer, V. Devauges, J. Cossec, G. Liot, S. Lecart et al., Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis, The FASEB Journal, vol.25, issue.4, pp.1295-1305, 2011.
DOI : 10.1096/fj.10-168633

R. Cutler, J. Kelly, K. Storie, W. Pedersen, T. A. Hatanpaa et al., Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease, Proceedings of the National Academy of Sciences, vol.101, issue.7, pp.2070-2075, 2004.
DOI : 10.1073/pnas.0305799101

A. Lazar, C. Bich, M. Panchal, N. Desbenoit, V. Petit et al., Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients, Acta Neuropathologica, vol.29, issue.3, pp.133-144, 2012.
DOI : 10.1007/s00401-012-1041-1
URL : https://hal.archives-ouvertes.fr/hal-00772814

M. Panchal, J. Loeper, J. Cossec, C. Perruchini, A. Lazar et al., Enrichment of cholesterol in microdissected Alzheimer's disease senile plaques as assessed by mass spectrometry, The Journal of Lipid Research, vol.51, issue.3, pp.598-605, 2010.
DOI : 10.1194/jlr.M001859

A. Mandas, A. Diaz, G. Abete, C. Cocco, P. Angius et al., Accumulation of neutral lipids in peripheral blood mononuclear cells as a distinctive trait of Alzheimer patients and asymptomatic subjects at risk of disease, BMC Med, vol.7, p.66, 2009.

A. Mandas, C. Abete, P. Putzu, P. La-colla, S. Dessi et al., Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients, Lipids in Health and Disease, vol.11, issue.1, p.39, 2012.
DOI : 10.1016/S0896-6273(03)00434-3