Transcriptional regulation of mononuclear phagocyte development - Sorbonne Université Access content directly
Journal Articles Frontiers in Immunology Year : 2015

Transcriptional regulation of mononuclear phagocyte development


Mononuclear phagocytes (MP) are a quite unique subset of hematopoietic cells, which comprise dendritic cells (DC), monocytes as well as monocyte-derived and tissue-resident macrophages. These cells are extremely diverse with regard to their origin, their phenotype as well as their function. Developmentally, DC and monocytes are constantly replenished from a bone marrow hematopoietic progenitor. The ontogeny of macrophages is more complex and is temporally linked and specified by the organ where they reside, occurring early during embryonic or perinatal life. The functional heterogeneity of MPs is certainly a consequence of the tissue of residence and also reflects the diverse ontogeny of the subsets. In this review, we will highlight the developmental pathways of murine MP, with a particular emphasis on the transcriptional factors that regulate their development and function. Finally, we will discuss and point out open questions in the field.
Fichier principal
Vignette du fichier
fimmu-06-00533.pdf (860.08 Ko) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

hal-01266086 , version 1 (02-02-2016)





Roxane Tussiwand, Emmanuel L. Gautier. Transcriptional regulation of mononuclear phagocyte development. Frontiers in Immunology, 2015, 6, pp.533. ⟨10.3389/fimmu.2015.00533⟩. ⟨hal-01266086⟩
218 View
345 Download



Gmail Facebook X LinkedIn More