Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease - Sorbonne Université
Journal Articles Alzheimer's & Dementia : the Journal of the Alzheimer's Association Year : 2016

Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease

Abstract

Introduction: The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain. Methods: We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association study. Results: We confirm that variation in/near APOE/TOMM40 (P 5 6 ! 10 214) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] 5 2.03, typical AD: OR 5 2.83, P 5 .0007). We found evidence for risk in/near CR1 (P 5 7 ! 10 24), ABCA7 (P 5 .02) and BIN1 (P 5 .04). ORs at variants near INPP5D and NME8 did not overlap between PCA and typical AD.
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hal-01289466 , version 1 (16-03-2016)

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Jonathan M. Schott, Sebastian J. Crutch, Minerva M. Carrasquillo, James Uphill, Tim J. Shakespeare, et al.. Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2016, ⟨10.1016/j.jalz.2016.01.010⟩. ⟨hal-01289466⟩
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