Hypothalamic neurogenesis persists in the aging brain and is controlled by energy-sensing IGF-I pathway - Sorbonne Université Access content directly
Journal Articles Neurobiology of Aging Year : 2016

Hypothalamic neurogenesis persists in the aging brain and is controlled by energy-sensing IGF-I pathway

Abstract

Hypothalamic tanycytes are specialized glial cells lining the third ventricle. They are recently identified as adult stem and/or progenitor cells, able to self-renew and give rise to new neurons postnatally. However, the long-term neurogenic potential of tanycytes and the pathways regulating lifelong cell replacement in the adult hypothalamus are largely unexplored. Using inducible nestin-CreERT2 for conditional mutagenesis, we performed lineage tracing of adult hypothalamic stem and/or progenitor cells (HySC) and demonstrated that new neurons continue to be born throughout adult life. This neurogenesis was targeted to numerous hypothalamic nuclei and produced different types of neurons in the dorsal periventricular regions. Some adult-born neurons integrated the median eminence and arcuate nucleus during aging and produced growth hormone releasing hormone. We showed that adult hypothalamic neurogenesis was tightly controlled by insulin-like growth factors (IGF). Knockout of IGF-1 receptor from hypothalamic stem and/or progenitor cells increased neuronal production and enhanced α-tanycyte self-renewal, preserving this stem cell–like population from age-related attrition. Our data indicate that adult hypothalamus retains the capacity of cell renewal, and thus, a substantial degree of structural plasticity throughout lifespan.
Fichier principal
Vignette du fichier
Chaker_2016_Hypothalamic.pdf (1.42 Mo) Télécharger le fichier
Origin Files produced by the author(s)
Loading...

Dates and versions

hal-01297761 , version 1 (06-04-2016)

Identifiers

Cite

Zayna Chaker, Caroline George, Marija Petrovska, Jean-Baptiste Caron, Philippe Lacube, et al.. Hypothalamic neurogenesis persists in the aging brain and is controlled by energy-sensing IGF-I pathway. Neurobiology of Aging, 2016, 41, pp. 64-72. ⟨10.1016/j.neurobiolaging.2016.02.008⟩. ⟨hal-01297761⟩
594 View
1220 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More