M. Baba, T. Imai, M. Nishimura, M. Kakizaki, S. Takagi et al., Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC, Journal of Biological Chemistry, vol.272, issue.23, pp.1997-32700056, 1997.
DOI : 10.1074/jbc.272.23.14893

D. Greaves, W. Wang, D. Dairaghi, M. Dieu, B. Franzbacon et al., CCR6, a CC Chemokine Receptor that Interacts with Macrophage Inflammatory Protein 3?? and Is Highly Expressed in Human Dendritic Cells, The Journal of Experimental Medicine, vol.82, issue.6, pp.837-881, 1997.
DOI : 10.1074/jbc.272.23.14893

F. Liao, R. Rabin, C. Smith, G. Sharma, T. Nutman et al., CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3?, Journal of Immunology, vol.162, issue.1, pp.186-94, 1999.

D. Cook, D. Prosser, R. Forster, J. Zhang, N. Kuklin et al., CCR6 Mediates Dendritic Cell Localization, Lymphocyte Homeostasis, and Immune Responses in Mucosal Tissue, Immunity, vol.12, issue.5, pp.495-503, 2000.
DOI : 10.1016/S1074-7613(00)80201-0

L. Borgne, M. Etchart, N. Goubier, A. Lira, S. Sirard et al., Dendritic Cells Rapidly Recruited into Epithelial Tissues via CCR6/CCL20 Are Responsible for CD8+ T Cell Crosspriming In Vivo, Immunity, vol.24, issue.2, pp.191-201000235479000010, 2006.
DOI : 10.1016/j.immuni.2006.01.005

URL : https://hal.archives-ouvertes.fr/inserm-00000041

A. Lechner, U. Ritter, R. Varona, G. Marquez, C. Bogdan et al., Protective immunity and delayed type hypersensitivity reaction are uncoupled in experimental Leishmania major infection of CCR6-negative mice, Microbes and Infection, vol.9, issue.3, pp.291-9000245760600005, 2007.
DOI : 10.1016/j.micinf.2006.12.002

R. Salazar-gonzalez, J. Niess, D. Zammit, R. Ravindran, A. Srinivasan et al., CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches, Immunity, vol.24, issue.5, pp.623-32000237970100018, 2006.
DOI : 10.1016/j.immuni.2006.02.015

R. Varona, R. Villares, L. Carramolino, F. Goya, A. Zaballos et al., CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses, Journal of Clinical Investigation, vol.107, issue.6, pp.37-45, 2001.
DOI : 10.1172/JCI11297

D. Yang, O. Chertov, N. Bykovskaia, Q. Chen, M. Buffo et al., -Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6, Science, vol.286, issue.5439, p.000083121200059, 1999.
DOI : 10.1126/science.286.5439.525

URL : https://hal.archives-ouvertes.fr/hal-01258459

E. Acosta-rodriguez, L. Rivino, J. Geginat, D. Jarrossay, M. Gattorno et al., Surface phenotype and antigenic specificity of human interleukin 17???producing T helper memory cells, Nature Immunology, vol.179, issue.6, pp.639-685, 2007.
DOI : 10.1038/ni1467

F. Annunziato, L. Cosmi, V. Santarlasci, L. Maggi, F. Liotta et al., Phenotypic and functional features of human Th17 cells, The Journal of Experimental Medicine, vol.162, issue.8, pp.1849-61000248727700015, 2007.
DOI : 10.1634/stemcells.2005-0008

S. Singh, H. Zhang, J. Foley, M. Hedrick, and J. Farber, Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6, The Journal of Immunology, vol.180, issue.1, pp.214-235, 2008.
DOI : 10.4049/jimmunol.180.1.214

R. Krzysiek, E. Lefevre, J. Bernard, A. Foussat, P. Galanaud et al., Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3 alpha/CCL20 in human B cells, Blood, vol.96, issue.7, pp.2338-2383, 2000.

N. Serafini, C. Vosshenrich, D. Santo, and J. , Transcriptional regulation of innate lymphoid cell fate, Nature Reviews Immunology, vol.157, issue.7, pp.415-443, 2015.
DOI : 10.1016/j.cell.2014.08.026

URL : https://hal.archives-ouvertes.fr/pasteur-01168713

M. Dieu, B. Vanbervliet, A. Vicari, J. Bridon, E. Oldham et al., Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites, The Journal of Experimental Medicine, vol.160, issue.2, pp.373-86000075236900015, 1998.
DOI : 10.1126/science.279.5349.381

A. Reboldi, C. Coisne, D. Baumjohann, F. Benvenuto, D. Bottinelli et al., C-C chemokine receptor 6???regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE, Nature Immunology, vol.181, issue.5, pp.514-23000265394400013, 2009.
DOI : 10.1002/glia.1101

A. Liston, R. Kohler, S. Townley, S. Haylock-jacobs, I. Comerford et al., Inhibition of CCR6 Function Reduces the Severity of Experimental Autoimmune Encephalomyelitis via Effects on the Priming Phase of the Immune Response, The Journal of Immunology, vol.182, issue.5, pp.3121-30000263653100064, 2009.
DOI : 10.4049/jimmunol.0713169

K. Hirota, H. Yoshitomi, M. Hashimoto, S. Maeda, S. Teradaira et al., Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model, The Journal of Experimental Medicine, vol.162, issue.12, pp.18025126-2118525, 2007.
DOI : 10.4049/jimmunol.170.12.6298

Y. Kochi, Y. Okada, A. Suzuki, K. Ikari, C. Terao et al., A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility, Nature Genetics, vol.5, issue.6, pp.515-63000278081500017, 2010.
DOI : 10.1136/ard.2007.085704

E. Stahl, S. Raychaudhuri, E. Remmers, G. Xie, S. Eyre et al., Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci, Nature Genetics, vol.447, issue.6, pp.508-56000278081500016, 2010.
DOI : 10.1038/ng.468

S. Hauser, E. Waubant, D. Arnold, T. Vollmer, J. Antel et al., B-Cell Depletion with Rituximab in Relapsing???Remitting Multiple Sclerosis, New England Journal of Medicine, vol.358, issue.7, pp.676-88, 2008.
DOI : 10.1056/NEJMoa0706383

E. Butcher and L. Picker, Lymphocyte Homing and Homeostasis, Science, vol.272, issue.5258, pp.60-66, 1996.
DOI : 10.1126/science.272.5258.60

J. Campbell, J. Hedrick, A. Zlotnik, M. Siani, D. Thompson et al., Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions, Science, vol.279, issue.5349, pp.381-4000071570800046, 1998.
DOI : 10.1126/science.279.5349.381

S. Ghannam, C. Dejou, N. Pedretti, J. Giot, K. Dorgham et al., CCL20 and ??-Defensin-2 Induce Arrest of Human Th17 Cells on Inflamed Endothelium In Vitro under Flow Conditions, The Journal of Immunology, vol.186, issue.3, pp.1411-20000286381200019, 2011.
DOI : 10.4049/jimmunol.1000597

J. Pene, C. S. Preisser, L. Venereau, E. Guilleux, M. Ghannam et al., Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes, The Journal of Immunology, vol.180, issue.11, pp.7423-7453, 2008.
DOI : 10.4049/jimmunol.180.11.7423

H. Yssel and H. Spits, Generation and Maintenance of Cloned Human T Cell Lines, Curr Protoc Immunol, vol.72, 2002.
DOI : 10.1002/0471142735.im0719s47

H. Yssel, J. De-vries, M. Koken, W. Van-blitterswijk, and H. Spits, Serum-free medium for generation and propagation of functional human cyto-toxic and helper t-cell clones, Journal of Immunological Methods, vol.7284, issue.1, pp.219-246, 1984.

T. Chen, Insitu detection of mycoplasma contamination in cell-cultures by fluorescent hoechst-33258 stain, PMID: WOS:A1977CW56300003, pp.255-62, 1977.

Z. Raja, S. Andre, C. Piesse, D. Sereno, P. Nicolas et al., Antimicrobial Activities and Mode of Interaction with Membranes of Bovel Phylloseptins from the Painted-Belly Leaf Frog, Phyllomedusa sauvagii, Plos One, vol.8, issue.8, p.000323115800021, 2013.

W. Yokoyama, M. Christensen, D. Santos, G. Miller, D. Ho et al., Production of monoclonal antibodies. Current protocols in immunology, p.24510488, 2013.

K. Dorgham, I. Dogan, N. Bitton, C. Parizot, V. Cardona et al., Immunogenicity of HIV Type 1 gp120 CD4 Binding Site Phage Mimotopes, AIDS Research and Human Retroviruses, vol.21, issue.1, pp.82-92, 2005.
DOI : 10.1089/aid.2005.21.82

X. Brochet, M. Lefranc, V. Giudicelli, and . Imgt-/-v-quest, IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis, Nucleic Acids Research, vol.36, issue.Web Server, pp.503-511, 2008.
DOI : 10.1093/nar/gkn316

URL : https://hal.archives-ouvertes.fr/hal-00322389

V. Giudicelli, X. Brochet, M. Lefranc, and . Imgt-/-v-quest, IMGT/V-QUEST: IMGT Standardized Analysis of the Immunoglobulin (IG) and T Cell Receptor (TR) Nucleotide Sequences, Cold Spring Harbor Protocols, vol.2011, issue.6, pp.695-715, 2011.
DOI : 10.1101/pdb.prot5633

URL : https://hal.archives-ouvertes.fr/hal-00616475

L. Ai, S. Lee, S. Chen, and F. Liao, Molecular characterization of CCR6: Involvement of multiple domains in ligand binding and receptor signaling, Journal of Biomedical Science, vol.286, issue.6, pp.818-846, 2004.
DOI : 10.1007/BF02254367

Q. Tan, Y. Zhu, J. Li, Z. Chen, G. Han et al., Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex, Science, vol.341, issue.6152, p.000324597200045, 2013.
DOI : 10.1126/science.1241475

L. Qin, I. Kufareva, L. Holden, C. Wang, Y. Zheng et al., Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine, Science, vol.347, issue.6226, pp.1117-22000350354200047, 2015.
DOI : 10.1126/science.1261064

B. Wu, E. Chien, C. Mol, G. Fenalti, W. Liu et al., Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists, Science, vol.330, issue.6007, pp.1066-71000284374700033, 2010.
DOI : 10.1126/science.1194396

J. Burg, J. Ingram, A. Venkatakrishnan, K. Jude, A. Dukkipati et al., Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor, Science, vol.347, issue.6226, pp.1113-1120, 2015.
DOI : 10.1126/science.aaa5026

S. Misumi, M. Endo, R. Mukai, K. Tachibana, M. Umeda et al., A Novel Cyclic Peptide Immunization Strategy for Preventing HIV-1/AIDS Infection and Progression, Journal of Biological Chemistry, vol.278, issue.34, pp.32335-43000184782100111, 2003.
DOI : 10.1074/jbc.M301209200

S. Misumi, R. Nakajima, N. Takamune, and S. Shoji, A cyclic dodecapeptide-multiple-antigen peptide conjugate from the undecapeptidyl arch (from Arg(168) to Cys(178)) of extracellular loop 2 in CCR5 as a novel human immunodeficiency virus type 1 vaccine, Journal of Virology, vol.75, issue.23, p.000172033100038, 2001.

L. Carramolino, L. Kremer, I. Goya, R. Varona, J. Buesa et al., Down-regulation of the betachemokine receptor CCR6 in dendritic cells mediated by TNF-alpha and IL-4, J Leukoc Biol, vol.66, issue.5, pp.837-881, 1999.

P. Hornbeck, T. Fleisher, and N. Papadopoulos, Isotype determination of antibodies. Current protocols in immunology, 2001.

C. Mackay, Moving targets: cell migration inhibitors as new anti-inflammatory therapies, Nature Immunology, vol.13, issue.9, pp.988-98, 2008.
DOI : 10.1038/ni.f.210

D. Scholten, M. Canals, D. Maussang, L. Roumen, M. Smit et al., Pharmacological modulation of chemokine receptor function, British Journal of Pharmacology, vol.106, issue.1, pp.1617-43000300689800003, 2012.
DOI : 10.1111/j.1476-5381.2011.01551.x

S. Say, M. Silva, A. Keita, M. Larsson, P. Andersson et al., CD83(+)CCR7(-) Dendritic Cells Accumulate in the Subepithelial Dome and Internalize Translocated Escherichia coli HB101 in the Peyer's Patches of Heal Crohn's Disease, American Journal of Pathology, vol.174, issue.1, pp.82-90000262219400009, 2009.

Y. Minamiya, H. Saito, N. Takahashi, M. Ito, H. Toda et al., Expression of the chemokine receptor CCR6 correlates with a favorable prognosis in patients with adenocarcinoma of the lung, Tumor Biology, vol.49, issue.1, pp.197-202000285469700021, 2011.
DOI : 10.1007/s13277-010-0113-x

E. Kim, V. Vasilyeva, S. Abbasova, E. Ivanova, E. Ovchinnikova et al., Human monoclonal antibodies against human chemokine receptor ccr6: Google Patents, 2013.

Y. Isoda, M. Koyama, Y. Kanda, and K. Yamano, Anticorps anti-ccr6 humain: Google Patents, 2013.

A. Klarenbeek, D. , C. Blanchetot, M. Saunders, S. Van-der-woning et al., Targeting chemokines and chemokine receptors with antibodies, Drug Discovery Today: Technologies, vol.9, issue.4, pp.227-31424063738, 2012.
DOI : 10.1016/j.ddtec.2012.05.003

B. Ma, M. Alam, E. Go, X. Lu, H. Desaire et al., Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies, PLoS Pathogens, vol.310, issue.1, p.000295409000012, 2011.
DOI : 10.1371/journal.ppat.1002200.s010

D. Sok, K. Doores, B. Briney, K. Le, K. Saye-francisco et al., Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV, Science Translational Medicine, vol.6, issue.236, p.000336668300008, 2014.
DOI : 10.1126/scitranslmed.3008104

R. Elgueta, E. Marks, E. Nowak, S. Menezes, M. Benson et al., CCR6-Dependent Positioning of Memory B Cells Is Essential for Their Ability To Mount a Recall Response to Antigen, The Journal of Immunology, vol.194, issue.2, pp.505-518, 2015.
DOI : 10.4049/jimmunol.1401553

A. Rubbert-roth, P. Tak, C. Zerbini, J. Tremblay, L. Carreno et al., Efficacy and safety of various repeat treatment dosing regimens of rituximab in patients with active rheumatoid arthritis: results of a Phase III randomized study (MIRROR), Rheumatology, vol.49, issue.9, pp.1683-93, 2010.
DOI : 10.1093/rheumatology/keq116

A. Dufour, G. Palermo, E. Zellmeier, G. Mellert, G. Duchateau-nguyen et al., Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients, Blood, vol.121, issue.18, pp.3650-3657, 2013.
DOI : 10.1182/blood-2012-10-458695

M. Weisser, R. Yeh, G. Duchateau-nguyen, G. Palermo, T. Quang et al., PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia, Blood, vol.124, issue.3, pp.420-425, 2014.
DOI : 10.1182/blood-2013-12-538975