Human basophils may not undergo modulation by DC-SIGN and mannose receptor–targeting immunotherapies due to absence of receptors
Résumé
Sirvent et al1 recently showed that novel vaccines targeting dendritic cells (DCs) by coupling glutaraldehyde-polymerized grass pollen allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1. Mechanistically, they found that nonoxidized mannan-coupled glutaraldehyde-polymerized grass pollen allergoids are captured and internalized by 2 lectin receptors on DCs: mannose receptor (CD206) and DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN or CD209). These data thus indicated that DCs could be targeted by C-type lectin receptors for efficient allergen immunotherapy.
Domaines
Immunologie
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