Skip to Main content Skip to Navigation
Journal articles

Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department

Abstract : Objective To prospectively validate qSOFA as a mortality predictor and compare the performances of the new sepsis criteria to the previous ones. Design, Settings, and Participants International prospective cohort study, conducted in France, Spain, Belgium, and Switzerland between May and June 2016. In the 30 participating emergency departments, for a 4-week period, consecutive patients who visited the emergency departments with suspected infection were included. All variables from previous and new definitions of sepsis were collected. Patients were followed up until hospital discharge or death. Exposures Measurement of qSOFA, SOFA, and SIRS. Main Outcomes and Measures In-hospital mortality. Results Of 1088 patients screened, 879 were included in the analysis. Median age was 67 years (interquartile range, 47-81 years), 414 (47%) were women, and 379 (43%) had respiratory tract infection. Overall in-hospital mortality was 8%: 3% for patients with a qSOFA score lower than 2 vs 24% for those with qSOFA score of 2 or higher (absolute difference, 21%; 95% CI, 15%-26%). The qSOFA performed better than both SIRS and severe sepsis in predicting in-hospital mortality, with an area under the receiver operating curve (AUROC) of 0.80 (95% CI, 0.74-0.85) vs 0.65 (95% CI, 0.59-0.70) for both SIRS and severe sepsis (P < .001; incremental AUROC, 0.15; 95% CI, 0.09-0.22). The hazard ratio of qSOFA score for death was 6.2 (95% CI, 3.8-10.3) vs 3.5 (95% CI, 2.2-5.5) for severe sepsis. Conclusions and Relevance Among patients presenting to the emergency department with suspected infection, the use of qSOFA resulted in greater prognostic accuracy for in-hospital mortality than did either SIRS or severe sepsis. These findings provide support for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) criteria in the emergency department setting.
Document type :
Journal articles
Complete list of metadata
Contributor : Gestionnaire Hal-Upmc Connect in order to contact the contributor
Submitted on : Tuesday, March 7, 2017 - 2:35:59 PM
Last modification on : Wednesday, January 26, 2022 - 4:47:54 PM
Long-term archiving on: : Thursday, June 8, 2017 - 2:11:31 PM


Files produced by the author(s)



Yonathan Freund, Najla Lemachatti, Evguenia Krastinova, Mar van Laer, Yann-Erick Claessens, et al.. Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department. Journal of the American Medical Association, American Medical Association (AMA), 2017, 317 (3), pp.301-308. ⟨10.1001/jama.2016.20329⟩. ⟨hal-01484589⟩



Les métriques sont temporairement indisponibles