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*. Median and (. Number, ? Significance between treatment groups determined using Kruskal- Wallis test for continuous variables and Pearson ?² test or Fisher's exact test for categorical variables. (n=237) P ? Demographics at inclusion Sex ratio, males/females (% males, pp.56-71

*. Median, ** Number (%) ? Significance between treatment groups determined using Kruskal-Wallis test for continuous variables and Pearson ?² test or Fisher's exact test for categorical variables