Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens

Claire Valotteau 1, 2 Ibrahim M. Banat 3 Christopher A. Mitchell 3 Helen Lydon 3 Roger Marchant 3 Florence Babonneau 1 Claire-Marie Pradier 2 Niki Baccile 1, * Vincent Humblot 2, *
* Auteur correspondant
1 SMiLES - Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé
LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris
2 LRS - Laboratoire de Réactivité de Surface
3 School of Biomedical Sciences
Abstract : Sophorolipids are bioderived glycolipids displaying interesting antimicrobial properties. We show that they can be used to develop biocidal monolayers against Listeria ivanovii, a Gram-positive bacterium. The present work points out the dependence between the surface density and the antibacterial activity of grafted sophorolipids. It also emphasizes the broad spectrum of activity of these coatings, demonstrating their potential against both Gram-positive strains (Enteroccocus faecalis, Staphylococcus epidermidis, Streptococcus pyogenes) and Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa and Salmonella typhymurium). After exposure to sophorolipids grafted onto gold, all these bacterial strains show a significant reduction in viability resulting from membrane damage as evidenced by fluorescent labelling and SEM-FEG analysis.
Keywords : Sophorolipid antibacterial surface membrane- damaging activity self-assembled monolayers
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Article dans une revue
Colloids and Surfaces B: Biointerfaces, Elsevier, 2017, 157, pp.325-334. 〈10.1016/j.colsurfb.2017.05.072〉
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Claire Valotteau, Ibrahim M. Banat, Christopher A. Mitchell, Helen Lydon, Roger Marchant, et al.. Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens. Colloids and Surfaces B: Biointerfaces, Elsevier, 2017, 157, pp.325-334. 〈10.1016/j.colsurfb.2017.05.072〉. 〈hal-01535615〉

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