Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints, Nature, vol.296, issue.7119, pp.633-640, 2006. ,
DOI : 10.1016/S0002-9440(10)63393-7
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas, Nature, vol.98, issue.7128, pp.656-60, 2007. ,
DOI : 10.1038/nature05529
Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation, Molecular and Cellular Biology, vol.18, issue.4, pp.1793-801, 1998. ,
DOI : 10.1128/MCB.18.4.1793
p53 mutations in human cancers, Science, vol.253, issue.5015, pp.49-53, 1991. ,
DOI : 10.1126/science.1905840
p16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells, Cancer Res, vol.59, issue.12, pp.2957-64, 1999. ,
Specific association of human telomerase activity with immortal cells and cancer, Science, vol.266, issue.5193, pp.2011-2016, 1994. ,
DOI : 10.1126/science.7605428
A survey of telomerase activity in human cancer, European Journal of Cancer, vol.33, issue.5, pp.787-91, 1997. ,
DOI : 10.1016/S0959-8049(97)00062-2
Caveolin-1 Regulates the Antagonistic Pleiotropic Properties of Cellular Senescence through a Novel Mdm2/p53-Mediated Pathway, Cancer Research, vol.69, issue.7, pp.2878-86, 2009. ,
DOI : 10.1158/0008-5472.CAN-08-2857
Evidence that senescent human prostate epithelial cells enhance tumorigenicity: Cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT, International Journal of Cancer, vol.22, issue.7, pp.1483-95, 2008. ,
DOI : 10.1128/MCB.3.4.523
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging, Proceedings of the National Academy of Sciences, vol.57, issue.9, pp.12072-12079, 2001. ,
DOI : 10.1073/pnas.91.9.3749
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC59769
Senescent Human Fibroblasts Increase the Early Growth of Xenograft Tumors via Matrix Metalloproteinase Secretion, Cancer Research, vol.67, issue.7, pp.3117-3143, 2007. ,
DOI : 10.1158/0008-5472.CAN-06-3452
Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol, pp.354-363, 2011. ,
DOI : 10.1016/j.semcancer.2011.09.001
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230665
Cellular Senescence in Cancer and Aging, Cell, vol.130, issue.2, pp.223-256, 2007. ,
DOI : 10.1016/j.cell.2007.07.003
The Gene Expression Program of Prostate Fibroblast Senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms, Cancer Research, vol.66, issue.2, pp.794-802, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-1716
The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells, Carcinogenesis, vol.36, issue.10, pp.1180-92, 2015. ,
DOI : 10.1093/carcin/bgv101
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression, Annual Review of Pathology: Mechanisms of Disease, vol.5, issue.1, pp.99-118, 2010. ,
DOI : 10.1146/annurev-pathol-121808-102144
Senescence-associated inflammatory responses: aging and cancer perspectives, Trends in Immunology, vol.36, issue.4, pp.217-245, 2015. ,
DOI : 10.1016/j.it.2015.02.009
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor, PLoS Biology, vol.49, issue.12, pp.2853-68, 2008. ,
DOI : 10.1371/journal.pbio.0060301.sd018
Prognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormone-refractory metastatic breast cancer patients, British Journal of Cancer, vol.88, issue.11, pp.1721-1727, 2003. ,
DOI : 10.1038/sj.bjc.6600956
Increased Serum Interleukin-8 in Patients with Early and Metastatic Breast Cancer Correlates with Early Dissemination and Survival, Clinical Cancer Research, vol.10, issue.21, pp.7157-62, 2004. ,
DOI : 10.1158/1078-0432.CCR-04-0812
Significance of interleukin-6 (IL-6) in breast cancer (review), Breast Cancer Research and Treatment, vol.49, issue.1, pp.129-164, 2007. ,
DOI : 10.1007/s10549-006-9328-3
Role of interleukin-8 in the progression of estrogen receptor-negative breast cancer, Chin Med J (Engl), vol.120, issue.20, pp.1766-72, 2007. ,
Epithelial mesenchymal transition traits in human breast cancer cell lines, Clinical & Experimental Metastasis, vol.172, issue.2, pp.629-671, 2008. ,
DOI : 10.1155/2001/850531
Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacities, Cell Growth Differ, vol.2, issue.8, pp.365-72, 1991. ,
Oestrogen receptor negative breast cancers exhibit high cytokine content, Breast Cancer Research, vol.9, issue.1, p.15, 2007. ,
DOI : 10.1186/bcr1648
URL : https://hal.archives-ouvertes.fr/inserm-00143810
Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion, Proceedings of the National Academy of Sciences, vol.17, issue.10, pp.1397-402, 2011. ,
DOI : 10.1101/gad.1061803
Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells, Cellular Signalling, vol.25, issue.4, pp.961-970, 2013. ,
DOI : 10.1016/j.cellsig.2013.01.007
Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population, Molecular Cell, vol.47, issue.4, pp.570-84, 2012. ,
DOI : 10.1016/j.molcel.2012.06.014
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland, Journal of Clinical Investigation, vol.117, issue.12, pp.3988-4002, 2007. ,
DOI : 10.1172/JCI32533DS1
Effect of Cellular Senescence on the Growth of HER2-Positive Breast Cancers, JNCI Journal of the National Cancer Institute, vol.107, issue.5, 2015. ,
DOI : 10.1093/jnci/djv020
Identification of interleukin-8 as estrogen receptor-regulated factor involved in breast cancer invasion and angiogenesis by protein arrays, International Journal of Cancer, vol.88, issue.4, pp.507-522, 2004. ,
DOI : 10.1016/S0002-9440(10)64005-9
The Interleukin-8 Pathway in Cancer, Clinical Cancer Research, vol.14, issue.21, pp.6735-6776, 2008. ,
DOI : 10.1158/1078-0432.CCR-07-4843
Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells, Breast Cancer Research, vol.72, issue.24 Suppl, p.210, 2013. ,
DOI : 10.1186/bcr3436
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978717
Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature, Cancer Research, vol.69, issue.4, pp.1302-1315, 2009. ,
DOI : 10.1158/0008-5472.CAN-08-2741
URL : https://hal.archives-ouvertes.fr/hal-01431954
Growth of Triple-Negative Breast Cancer Cells Relies upon Coordinate Autocrine Expression of the Proinflammatory Cytokines IL-6 and IL-8, Cancer Research, vol.73, issue.11, pp.3470-80, 2013. ,
DOI : 10.1158/0008-5472.CAN-12-4524-T
Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence, Cell, vol.133, issue.6, pp.1006-1024, 2008. ,
DOI : 10.1016/j.cell.2008.03.038
URL : http://doi.org/10.1016/j.cell.2008.03.038
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network, Cell, vol.133, issue.6, pp.1019-1050, 2008. ,
DOI : 10.1016/j.cell.2008.03.039
URL : http://doi.org/10.1016/j.cell.2008.03.039
Smoldering and polarized inflammation in the initiation and promotion of malignant disease, Cancer Cell, vol.7, issue.3, pp.211-218, 2005. ,
DOI : 10.1016/j.ccr.2005.02.013
Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials, The Lancet, vol.377, issue.9759, pp.31-41, 2011. ,
DOI : 10.1016/S0140-6736(10)62110-1
Aspirin use and survival after the diagnosis of breast cancer: a population-based cohort study, British Journal of Cancer, vol.58, issue.3, pp.623-630, 2014. ,
DOI : 10.1126/science.8290962
Case-Control Study of Aspirin Use and Risk of Pancreatic Cancer, Cancer Epidemiology Biomarkers & Prevention, vol.23, issue.7, pp.1254-63, 2014. ,
DOI : 10.1158/1055-9965.EPI-13-1284
REDUCTION IN SERUM IL-6 AFTER VACINATION OF BREAST CANCER PATIENTS WITH TUMOUR-ASSOCIATED ANTIGENS IS RELATED TO ESTROGEN RECEPTOR STATUS, Cytokine, vol.12, issue.5, pp.458-65, 2000. ,
DOI : 10.1006/cyto.1999.0591
Interleukin-6 is a potent growth factor for ER-?-positive human breast cancer, The FASEB Journal, vol.21, issue.13, pp.3763-70, 2007. ,
DOI : 10.1096/fj.07-8832com
The Ability to Generate Senescent Progeny as a Mechanism Underlying Breast Cancer Cell Heterogeneity, PLoS ONE, vol.351, issue.6, p.11288, 2010. ,
DOI : 10.1371/journal.pone.0011288.s010
Analyzing real-time PCR data by the comparative CT method, Nature Protocols, vol.2, issue.6, pp.1101-1109, 2008. ,
DOI : 10.1593/neo.07916
Transcriptional control of adipocyte formation, Cell Metabolism, vol.4, issue.4, pp.263-73, 2006. ,
DOI : 10.1016/j.cmet.2006.07.001
The transcriptional basis of adipocyte development, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.73, issue.1, pp.31-35, 2005. ,
DOI : 10.1016/j.plefa.2005.04.004
Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation, Journal of Cell Science, vol.119, issue.3, pp.581-91, 2006. ,
DOI : 10.1242/jcs.02758
In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytes, Arthritis & Rheumatism, vol.21, issue.2, pp.450-459, 2009. ,
DOI : 10.1002/jbm.a.30560
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells, Cell, vol.133, issue.4, pp.704-719, 2008. ,
DOI : 10.1016/j.cell.2008.03.027
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition, PLoS ONE, vol.133, issue.8, p.2888, 2008. ,
DOI : 10.1371/journal.pone.0002888.g005
Senescent cells as a source of inflammatory factors for tumor progression, Cancer and Metastasis Reviews, vol.336, issue.15, pp.273-83, 2010. ,
DOI : 10.4049/jimmunol.166.11.6483
TGF-? signaling and epithelial?mesenchymal transition in cancer progression, Current Opinion in Oncology, vol.25, issue.1, pp.76-84, 2013. ,
DOI : 10.1097/CCO.0b013e32835b6371
Transforming growth factor-? signaling in epithelial-mesenchymal transition and progression of cancer, Proceedings of the Japan Academy, Series B, vol.85, issue.8, pp.314-337, 2009. ,
DOI : 10.2183/pjab.85.314
TGF-?-induced epithelial to mesenchymal transition, Cell Research, vol.3, issue.2, pp.156-72, 2009. ,
DOI : 10.1101/gad.276304
Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition, Oncogene, vol.17, issue.13, pp.1649-57, 2014. ,
DOI : 10.1242/jcs.02566
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934944
EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice, PLoS Genetics, vol.296, issue.5, p.1002723, 2012. ,
DOI : 10.1371/journal.pgen.1002723.s014
URL : https://hal.archives-ouvertes.fr/hal-00712474
Epithelial and Mesenchymal Subpopulations Within Normal Basal Breast Cell Lines Exhibit Distinct Stem Cell/Progenitor Properties, STEM CELLS, vol.8, issue.suppl 3, pp.292-303, 2012. ,
DOI : 10.1002/stem.791
Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression, Breast Cancer Research, vol.5, issue.Pt 20, p.202, 2011. ,
DOI : 10.1371/journal.pone.0010365
Survival of Mammary Stem Cells in Suspension Culture: Implications for Stem Cell Biology and Neoplasia, Journal of Mammary Gland Biology and Neoplasia, vol.101, issue.10, pp.75-86, 2005. ,
DOI : 10.5483/BMBRep.2003.36.1.043
Multi-lineage potential of human mesenchymal stem cells following clonal expansion, J Musculoskelet Neuronal Interact, vol.2, issue.1, pp.71-77, 2001. ,
Immunohistochemical Analysis of Human Mesenchymal Stem Cells Differentiating into Chondrogenic, Osteogenic, and Adipogenic Lineages, Methods Mol Biol, vol.698, pp.353-66, 2011. ,
DOI : 10.1007/978-1-60761-999-4_26
An embryonic stem cell???like gene expression signature in poorly differentiated aggressive human tumors, Nature Genetics, vol.22, issue.5, pp.499-507, 2008. ,
DOI : 10.1016/S0140-6736(05)17947-1
Choosing the right cell line for breast cancer research, Breast Cancer Research, vol.115, issue.11 Suppl, p.215, 2011. ,
DOI : 10.1007/s10549-008-0053-y
CD44+/CD24-breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis, Breast Cancer Research, vol.50, issue.5, p.59, 2006. ,
DOI : 10.1007/BF00204786
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779499
Triple negative breast cancers comprise a highly tumorigenic cell subpopulation detectable by its high responsiveness to a Sox2 regulatory region 2 (SRR2) reporter, Oncotarget, vol.6, issue.12, pp.10366-73, 2015. ,
DOI : 10.18632/oncotarget.3590
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496361
SNAIL Regulates Interleukin-8 Expression, Stem Cell?Like Activity, and Tumorigenicity of Human Colorectal Carcinoma Cells, Gastroenterology, vol.141, issue.1, pp.279-91, 2011. ,
DOI : 10.1053/j.gastro.2011.04.008
Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial?mesenchymal transition, Carcinogenesis, vol.36, issue.4, pp.459-68, 2015. ,
DOI : 10.1093/carcin/bgv017
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392608
Interleukin-6-induced epithelial-mesenchymal transition through signal transducer and activator of transcription 3 in human cervical carcinoma, International Journal of Oncology, vol.45, issue.1, pp.165-76, 2014. ,
DOI : 10.3892/ijo.2014.2422
IL-6 Promotes Head and Neck Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition via the JAK-STAT3-SNAIL Signaling Pathway, Molecular Cancer Research, vol.9, issue.12, pp.1658-67, 2011. ,
DOI : 10.1158/1541-7786.MCR-11-0271
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243808
IL-8 suppresses E-cadherin expression in nasopharyngeal carcinoma cells by enhancing E-cadherin promoter DNA methylation, International Journal of Oncology ,
DOI : 10.3892/ijo.2015.3226
Beyond tumorigenesis: cancer stem cells in metastasis, Cell Research, vol.65, issue.1, pp.3-14, 2007. ,
DOI : 10.1038/sj.cr.7310118
Bone marrow mesenchymal stem cells participate in prostate carcinogenesis and promote growth of prostate cancer by cell fusion <i>in vivo</i>, Oncotarget, vol.7, issue.21, pp.30924-30958, 2016. ,
DOI : 10.18632/oncotarget.9045
The potential role of liver stem cells in initiation of primary liver cancer, Hepatology International, vol.36, issue.3, pp.893-901, 2016. ,
DOI : 10.1007/s12072-016-9730-9
Interleukin-6 signaling pathway in targeted therapy for cancer, Cancer Treatment Reviews, vol.38, issue.7, pp.904-914, 2012. ,
DOI : 10.1016/j.ctrv.2012.04.007
Interleukin-6 and pro inflammatory status in the breast tumor microenvironment, World Journal of Surgical Oncology, vol.8, issue.7, p.129, 2015. ,
DOI : 10.1186/s12957-015-0529-2
Interleukin-8 and human cancer biology, Cytokine & Growth Factor Reviews, vol.12, issue.4, pp.375-91, 2001. ,
DOI : 10.1016/S1359-6101(01)00016-8
The role of interleukin-8 in cancer cells and microenvironment interaction, Frontiers in Bioscience, vol.10, issue.1-3, pp.853-65, 2005. ,
DOI : 10.2741/1579
IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells, Oncogene, vol.22, issue.2, pp.256-65, 2003. ,
DOI : 10.1038/sj.onc.1206113
URL : https://hal.archives-ouvertes.fr/inserm-00143840
A complex secretory program orchestrated by the inflammasome controls paracrine senescence, Nature Cell Biology, vol.122, issue.8, pp.978-90, 2013. ,
DOI : 10.1038/ncb2784
A senescent cell bystander effect: senescence-induced senescence, Aging Cell, vol.2, issue.Pt 1, pp.345-354, 2012. ,
DOI : 10.1111/j.1474-9726.2012.00795.x
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488292
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion, Nature Cell Biology, vol.11, issue.8, pp.973-982, 2009. ,
DOI : 10.1074/jbc.M408650200
Regulation of osteoblast formation and function, Reviews in Endocrine and Metabolic Disorders, vol.2, issue.1, pp.81-94, 2001. ,
DOI : 10.1023/A:1010011209064
Regulation of bone development and extracellular matrix protein genes by RUNX2, Cell and Tissue Research, vol.162, issue.1, pp.189-95, 2010. ,
DOI : 10.1016/B978-0-08-092500-4.50010-3
Metastatic breast cancer cells inhibit osteoblast differentiation through the Runx2/CBF?-dependent expression of the Wnt antagonist, sclerostin, Breast Cancer Research, vol.26, issue.5, p.106, 2011. ,
DOI : 10.1002/jbmr.307
Cancer stem cell heterogeneity in hereditary breast cancer, Breast Cancer Research, vol.21, issue.2, p.105, 2008. ,
DOI : 10.2165/00063030-200721050-00002