Adult’s onset Still disease occurring during pregnancy: Case-report and literature review

Abstract : Adult onset Still’s disease is a rare affection classified among non-hereditary autoinflammatory diseases. The clinical presentation goes from fever with arthralgia and maculopapular eruption to life-threatening manifestations such as secondary lymphohistiocytosis. The mechanisms of AOSD remains unclear, but seems implicate NK cells dysfunction with pro-inflammatory cytokines secretion including IL-1ß, IL-6 and IL-18 [1]. Several reports mentioned AOSD occurring during pregnancy, mostly in first and second trimester and there is still a debate on whether it could compromise or not the pregnancy outcome. We here report a case of AOSD revealed during pregnancy with a life-threatening presentation along with a review of 19 cases from literature.
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Dernière modification le : mercredi 21 mars 2018 - 18:57:40
Document(s) archivé(s) le : samedi 27 janvier 2018 - 07:27:59

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Léo Plaçais, Arsène Mekinian, Marie Bornes, Armelle Poujol-Robert, Naiké Bigé, et al.. Adult’s onset Still disease occurring during pregnancy: Case-report and literature review. Seminars in Arthritis and Rheumatism, WB Saunders, 2017, 〈10.1016/j.semarthrit.2017.07.003〉. 〈hal-01563953〉

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