Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes, Nature, vol.348, issue.6301, pp.510-51410348510, 1038. ,
DOI : 10.1038/348510a0
CLC Chloride Channels and Transporters: From Genes to Protein Structure, Pathology and Physiology, Critical Reviews in Biochemistry and Molecular Biology, vol.555, issue.1, pp.3-36, 2008. ,
DOI : 10.1113/jphysiol.2003.060046
FUNCTION OF CHLORIDE CHANNELS IN THE KIDNEY, Annual Review of Physiology, vol.67, issue.1, pp.759-778, 2005. ,
DOI : 10.1146/annurev.physiol.67.032003.153547
CLC channel function and dysfunction in health and disease, Frontiers in physiology, vol.5, issue.378, p.378, 2014. ,
ClC-K chloride channels: emerging pathophysiology of Bartter syndrome type 3, American Journal of Physiology - Renal Physiology, vol.308, issue.12, pp.1324-1334, 2015. ,
DOI : 10.1152/ajprenal.00004.2015
URL : http://ajprenal.physiology.org/content/ajprenal/308/12/F1324.full.pdf
Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel, Nature Genetics, vol.21, issue.1, pp.95-9810, 1999. ,
DOI : 10.1038/5036
Mutations in the chloride channel gene CLCNKB as a cause of classic Bartter syndrome, J Am Soc Nephrol, vol.11, pp.1449-1459, 2000. ,
Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III, Nature Genetics, vol.78, issue.2, pp.171-17810, 1997. ,
DOI : 10.1016/0002-9343(78)90794-5
Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure, Nature Genetics, vol.29, issue.3, pp.310-31410, 2001. ,
DOI : 10.1038/ng752
Salt Wasting and Deafness Resulting from Mutations in Two Chloride Channels, New England Journal of Medicine, vol.350, issue.13, pp.1314-131910, 2004. ,
DOI : 10.1056/NEJMoa032843
The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron, Journal of the American Society of Nephrology, vol.28, issue.1, p.2016010085, 2016. ,
DOI : 10.1681/ASN.2016010085
Salt-losing nephropathy in mice with a null mutation of the Clcnk2 gene, Acta Physiologica, vol.63, issue.3, pp.198-21110, 2016. ,
DOI : 10.1046/j.1523-1755.2003.00730.x
Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension, Human Molecular Genetics, vol.16, issue.13, pp.1630-1638, 2007. ,
DOI : 10.1093/hmg/ddm112
Activating Mutation of the Renal Epithelial Chloride Channel ClC-Kb Predisposing to Hypertension, Hypertension, vol.43, issue.6, pp.1175-1181, 2004. ,
DOI : 10.1161/01.HYP.0000129824.12959.f0
Global burden of blood-pressure-related disease, 2001, The Lancet, vol.371, issue.9623, pp.1513-151810, 2001. ,
DOI : 10.1016/S0140-6736(08)60655-8
Molecular Mechanisms of Human Hypertension, Cell, vol.104, issue.4, pp.545-556, 2001. ,
DOI : 10.1016/S0092-8674(01)00241-0
Blood pressure control--special role of the kidneys and body fluids, Science, vol.252, issue.5014, pp.1813-1816, 1991. ,
DOI : 10.1126/science.2063193
Novel diuretic targets, AJP: Renal Physiology, vol.305, issue.7, pp.931-942, 2013. ,
DOI : 10.1152/ajprenal.00230.2013
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798746
The hidden hand of chloride in hypertension, Pfl??gers Archiv - European Journal of Physiology, vol.275, issue.48, pp.595-60310, 2015. ,
DOI : 10.1074/jbc.M006218200
Molecular Requisites for Drug Binding to Muscle CLC-1 and Renal CLC-K Channel Revealed by the Use of Phenoxy-Alkyl Derivatives of 2-(p-Chlorophenoxy)Propionic Acid, Molecular Pharmacology, vol.62, issue.2, pp.265-271, 2002. ,
DOI : 10.1124/mol.62.2.265
Investigations of Pharmacologic Properties of the Renal CLC-K1 Chloride Channel Co-expressed with Barttin by the Use of 2-(p-Chlorophenoxy)Propionic Acid Derivatives and Other Structurally Unrelated Chloride Channels Blockers, Journal of the American Society of Nephrology, vol.15, issue.1, pp.13-20, 2004. ,
DOI : 10.1097/01.ASN.0000103226.28798.EA
Activation and inhibition of kidney CLC-K chloride channels by fenamates, Molecular Pharmacology, vol.69, pp.165-173, 2006. ,
DOI : 10.1124/mol.105.017384
Molecular switch for CLC-K Cl- channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands, Proceedings of the National Academy of Sciences, vol.58, issue.3, pp.1369-13730708977105, 2008. ,
DOI : 10.1124/mol.58.3.498
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234145
Kidney CLC-K chloride channels inhibitors, Journal of Hypertension, vol.34, issue.5, pp.981-99210, 2016. ,
DOI : 10.1097/HJH.0000000000000876
Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels, British Journal of Pharmacology, vol.158, issue.2, pp.1652-1661, 2010. ,
DOI : 10.1007/112_2006_0605
Physiology and Pathophysiology of ClC-K/barttin Channels. Frontiers in physiology 1, doi:10.3389/ fphys, p.155, 2010. ,
DOI : 10.3389/fphys.2010.00155
URL : http://doi.org/10.3389/fphys.2010.00155
Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle, Science, vol.211, issue.5052, pp.635-64110, 2010. ,
DOI : 10.1038/211969a0
Gating the Selectivity Filter in ClC Chloride Channels, Science, vol.300, issue.5616, pp.108-11210, 2003. ,
DOI : 10.1126/science.1082708
The Structure of the Cytoplasmic Domain of the Chloride Channel ClC-Ka Reveals a Conserved Interaction Interface, Structure, vol.15, issue.6, pp.715-725, 2007. ,
DOI : 10.1016/j.str.2007.04.013
Dissecting a regulatory calcium-binding site of CLC-K kidney chloride channels, The Journal of General Physiology, vol.268, issue.6, pp.681-69610, 2012. ,
DOI : 10.1152/physiol.00018.2009
Structure of a CLC chloride ion channel by cryo-electron microscopy, Nature, vol.3, issue.7638, pp.500-505, 2017. ,
DOI : 10.1093/hmg/3.6.941
The biostructural pathology of the serpins: critical function of sheet opening mechanism, Biol Chem Hoppe Seyler, vol.377, pp.1-17, 1996. ,
A theoretical model for the Gla-TSR-EGF-1 region of the anticoagulant cofactor protein S: from biostructural pathology to species-specific cofactor activity, Journal of Computer-Aided Molecular Design, vol.11, issue.3, pp.293-304, 1997. ,
DOI : 10.1023/A:1007912929828
Membrane proteins, detergents and crystals: what is the state of the art?, Acta Crystallographica Section F Structural Biology Communications, vol.247, issue.12, pp.1576-1583, 2014. ,
DOI : 10.1107/S2053230X14025035/en5558sup1.xlsx
PDBTM: Protein Data Bank of transmembrane proteins after 8 years, Nucleic Acids Research, vol.41, issue.D1, pp.524-52910, 2013. ,
DOI : 10.1093/nar/gks1169
URL : http://doi.org/10.1093/nar/gks1169
The Protein Data Bank, Nucleic Acids Research, vol.28, issue.1, pp.235-242, 2000. ,
DOI : 10.1093/nar/28.1.235
Relation between sequence and structure in membrane proteins, Bioinformatics, vol.29, issue.13, pp.1589-1592, 2013. ,
DOI : 10.1093/bioinformatics/btt249
X-ray structure of a ClC chloride channel at 3.0?????? reveals the molecular basis of anion selectivity, Nature, vol.415, issue.6869, pp.287-29410, 2002. ,
DOI : 10.1038/415287a
Tryptophan Scanning Mutagenesis Identifies the Molecular Determinants of Distinct Barttin Functions, Journal of Biological Chemistry, vol.5, issue.30, pp.18732-1874310, 2015. ,
DOI : 10.1085/jgp.201010455
Barttin binds to the outer lateral surface of the ClC-K2 chloride channel, Biochemical and Biophysical Research Communications, vol.362, issue.4, pp.858-864, 2007. ,
DOI : 10.1016/j.bbrc.2007.08.097
Modulation of ClC-K Channel Function by the Accessory Subunit Barttin, Journal of the American Society of Nephrology, vol.21, issue.8, pp.1238-12392010050555, 2010. ,
DOI : 10.1681/ASN.2010050555
: all-atom structure validation for macromolecular crystallography, Acta Crystallographica Section D Biological Crystallography, vol.285, issue.1, pp.12-21, 2010. ,
DOI : 10.1107/S0907444909042073
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803126/pdf
Molecular determinants of differential pore blocking of kidney CLC-K chloride channels, EMBO reports, vol.268, issue.6, pp.584-5897400169, 2004. ,
DOI : 10.1185/030079903125001668
Characterization of the mouse ClC-K1/Barttin chloride channel, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1828, issue.11, pp.2399-2409, 2013. ,
DOI : 10.1016/j.bbamem.2013.06.012
I???J loop involvement in the pharmacological profile of CLC-K channels expressed in Xenopus oocytes, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1838, issue.11, pp.2745-2756, 2014. ,
DOI : 10.1016/j.bbamem.2014.07.021
Barttin Activates ClC-K Channel Function by Modulating Gating, Journal of the American Society of Nephrology, vol.21, issue.8, pp.1281-12892009121274, 1681. ,
DOI : 10.1681/ASN.2009121274
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938600
Barttin modulates trafficking and function of ClC-K channels, Proceedings of the National Academy of Sciences, vol.279, issue.13, pp.11411-11416060163110310, 2006. ,
DOI : 10.1074/jbc.M312649200
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1544099
CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures, PLoS Computational Biology, vol.8, issue.10, 2012. ,
DOI : 10.1371/journal.pcbi.1002708.s013
A method and server for predicting damaging missense mutations, Nature Methods, vol.7, issue.4, pp.248-24910, 2010. ,
DOI : 10.1038/nmeth0410-248
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855889
PoPMuSiC 2.1: a web server for the estimation of protein stability changes upon mutation and sequence optimality, BMC Bioinformatics, vol.12, issue.1, pp.10-1186, 2011. ,
DOI : 10.1186/1471-2105-8-65
The FoldX web server: an online force field. Nucleic acids research 33, pp.382-388, 2005. ,
DOI : 10.1093/nar/gki387
URL : http://doi.org/10.1093/nar/gki387
ENCoM server: exploring protein conformational space and the effect of mutations on protein function and stability. Nucleic acids research 43, pp.395-40010, 2015. ,
The Stability Effects of Protein Mutations Appear to be Universally Distributed, Journal of Molecular Biology, vol.369, issue.5, pp.1318-1332, 2007. ,
DOI : 10.1016/j.jmb.2007.03.069
ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules, Nucleic Acids Research, vol.44, issue.W1, p.408, 2016. ,
DOI : 10.1093/nar/gkw408
URL : http://doi.org/10.1093/nar/gkw408
CLCNKB mutations causing mild Bartter syndrome profoundly alter the pH and Ca2+ dependence of ClC-Kb channels, Pfl??gers Archiv - European Journal of Physiology, vol.63, issue.1, pp.1713-172310, 2014. ,
DOI : 10.1046/j.1523-1755.2003.00730.x
Electrostatics of Ion Stabilization in a ClC Chloride Channel Homologue from Escherichia coli, Journal of Molecular Biology, vol.339, issue.4, pp.981-1000, 2004. ,
DOI : 10.1016/j.jmb.2004.04.023
Assessment of computational methods for predicting the effects of missense mutations in human cancers, BMC genomics, vol.14, p.7, 2013. ,
Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations, Genome Biology, vol.74, issue.10, pp.10-1186, 2014. ,
DOI : 10.1158/0008-5472.CAN-13-3375
URL : http://doi.org/10.1186/preaccept-6413622551325626
Molecular Pharmacology of Kidney and Inner Ear CLC-K Chloride Channels, Frontiers in Pharmacology, vol.1, issue.130, p.130, 2010. ,
DOI : 10.3389/fphar.2010.00130
One hundred thousand mouse clicks down the road: selected online resources supporting drug discovery collected over a decade, Drug Discovery Today, vol.18, issue.21-22, pp.1081-1089, 2013. ,
DOI : 10.1016/j.drudis.2013.06.013
Similarity-based virtual screening using 2D fingerprints, Drug Discovery Today, vol.11, issue.23-24, pp.1046-1053005, 2006. ,
DOI : 10.1016/j.drudis.2006.10.005
URL : http://eprints.whiterose.ac.uk/3605/1/willettp_DDT_review.pdf
Concepts and applications of molecular similarity, by Mark A. Johnson and Gerald M. Maggiora, eds., John Wiley & Sons, New York, 1990, 393 pp. Price: $65.00, Journal of Computational Chemistry, vol.13, issue.4, pp.539-54010, 1990. ,
DOI : 10.1002/jcc.540130415
e-Drug3D: 3D structure collections dedicated to drug repurposing and fragment-based drug design, Bioinformatics, vol.28, issue.11, pp.1540-154110, 2012. ,
DOI : 10.1093/bioinformatics/bts186
Surflex-Dock 2.1: Robust performance from ligand energetic modeling, ring flexibility, and knowledge-based search, Journal of Computer-Aided Molecular Design, vol.50, issue.5, pp.281-30610, 2007. ,
DOI : 10.1007/s10822-007-9114-2
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading, Journal of Computational Chemistry, vol.17, pp.455-461, 2010. ,
DOI : 10.1002/jcc.21334
Comparative Protein Modelling by Satisfaction of Spatial Restraints, Journal of Molecular Biology, vol.234, issue.3, pp.779-8151626, 1993. ,
DOI : 10.1006/jmbi.1993.1626
Protein Structure Modeling with MODELLER, Methods in molecular biology, vol.1137, pp.1-15, 2014. ,
DOI : 10.1007/978-1-4939-0366-5_1
EMBOSS: The European Molecular Biology Open Software Suite, Trends in Genetics, vol.16, issue.6, pp.276-277, 2000. ,
DOI : 10.1016/S0168-9525(00)02024-2
Modeling of loops in protein structures, Protein Science, vol.14, issue.9, pp.1753-1773, 2000. ,
DOI : 10.1002/ijch.199400028
Statistical potential for assessment and prediction of protein structures, Protein Science, vol.12, issue.11, pp.2507-2524062416606, 2006. ,
DOI : 10.1074/jbc.272.2.701
Scalable molecular dynamics with NAMD, Journal of Computational Chemistry, vol.84, issue.16, pp.1781-180220289, 2005. ,
DOI : 10.1515/9783110879476
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486339
Dihedral Angles, Journal of Chemical Theory and Computation, vol.8, issue.9, pp.3257-327310, 2012. ,
DOI : 10.1021/ct300400x
Importance of the CMAP Correction to the CHARMM22 Protein Force Field: Dynamics of Hen Lysozyme, Biophysical Journal, vol.90, issue.4, pp.36-38, 2006. ,
DOI : 10.1529/biophysj.105.078154
a, Proteins: Structure, Function, and Bioinformatics, vol.366, issue.12, pp.2186-219710, 2015. ,
DOI : 10.1016/j.jmb.2006.12.001
URL : https://hal.archives-ouvertes.fr/hal-00903617
CHARMM: The biomolecular simulation program, Journal of Computational Chemistry, vol.103, issue.13, pp.1545-161410, 2009. ,
DOI : 10.1021/ci034261e
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810661
OPM database and PPM web server: resources for positioning of proteins in membranes, Nucleic Acids Research, vol.40, issue.D1, pp.370-37610, 2012. ,
DOI : 10.1093/nar/gkr703
Comparison of simple potential functions for simulating liquid water, The Journal of Chemical Physics, vol.79, issue.2, pp.926-93510, 1983. ,
DOI : 10.1016/0009-2614(80)85344-9
) method for Ewald sums in large systems, The Journal of Chemical Physics, vol.9, issue.12, pp.10089-10092, 1993. ,
DOI : 10.1126/science.2548279
Constant pressure molecular dynamics simulation: The Langevin piston method, The Journal of Chemical Physics, vol.51, issue.11, pp.4613-462110, 1995. ,
DOI : 10.1002/jcc.540150702
VMD: Visual molecular dynamics, Journal of Molecular Graphics, vol.14, issue.1, pp.33-38, 1996. ,
DOI : 10.1016/0263-7855(96)00018-5
Electrostatics of nanosystems: Application to microtubules and the ribosome, Proceedings of the National Academy of Sciences, vol.377, issue.6547, pp.10037-1004110, 2001. ,
DOI : 10.1038/377309a0
Reduced surface: an efficient way to compute molecular surfaces, Biopolymers, vol.38383053, issue.3<, pp.305-32010, 1996. ,
DOI : 10.1002/(sici)1097-0282(199603)38:3<305::aid-bip4>3.3.co;2-8
FAF-Drugs3: a web server for compound property calculation and chemical library design, Nucleic Acids Research, vol.43, issue.W1, pp.200-20710, 2015. ,
DOI : 10.1093/nar/gkv353
URL : http://doi.org/10.1093/nar/gkv353
Comparison of Automatic Three-Dimensional Model Builders Using 639 X-ray Structures, Journal of Chemical Information and Modeling, vol.34, issue.4, pp.1000-1000810, 1994. ,
DOI : 10.1021/ci00020a039
PubChem Substance and Compound databases, Nucleic Acids Research, vol.44, issue.D1, pp.1202-1213, 2016. ,
DOI : 10.1093/nar/gkv951
URL : http://doi.org/10.1093/nar/gkv951
PubChem3D: a new resource for scientists, Journal of Cheminformatics, vol.3, issue.1, pp.10-1186, 2011. ,
DOI : 10.1093/nar/gkl320
URL : http://doi.org/10.1186/1758-2946-3-32
A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels, The Journal of General Physiology, vol.268, issue.3, pp.311-32310, 2011. ,
DOI : 10.1111/j.1476-5381.2010.00822.x
Deciphering key features in protein structures with the new ENDscript server. Nucleic acids research 42, pp.320-32410, 2014. ,
Mutations Causing Bartter Syndrome Affect Channel Surface Expression, Human Mutation, vol.22, issue.3, pp.1269-127822361, 2013. ,
DOI : 10.1016/S0896-6273(00)80708-4
Identification and functional analysis of novel mutations of the CLCNKB gene in Chinese patients with classic Bartter syndrome, Clinical Genetics, vol.534, issue.2, pp.155-162, 2010. ,
DOI : 10.1152/physrev.00029.2001
Functional and Structural Analysis of ClC-K Chloride Channels Involved in Renal Disease, Journal of Biological Chemistry, vol.200, issue.32, pp.24527-24533, 2000. ,
DOI : 10.1172/JCI119299