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Article Dans Une Revue Physical Review E Année : 2017

From cells to tissue: A continuum model of epithelial mechanics

Résumé

A two-dimensional continuum model of epithelial tissue mechanics was formulated using cellular-level mechanical ingredients and cell morphogenetic processes, including cellular shape changes and cellular rearrangements. This model incorporates stress and deformation tensors, which can be compared with experimental data. Focusing on the interplay between cell shape changes and cell rearrangements, we elucidated dynamical behavior underlying passive relaxation, active contraction-elongation, and tissue shear flow, including a mechanism for contraction-elongation, whereby tissue flows perpendicularly to the axis of cell elongation. This study provides an integrated scheme for the understanding of the orchestration of morphogenetic processes in individual cells to achieve epithelial tissue morphogenesis.

Dates et versions

hal-01580627 , version 1 (01-09-2017)

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Shuji Ishihara, Philippe Marcq, Kaoru Sugimura. From cells to tissue: A continuum model of epithelial mechanics. Physical Review E , 2017, 96 (2), ⟨10.1103/PhysRevE.96.022418⟩. ⟨hal-01580627⟩
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