Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity, Oncogene, vol.38, issue.40, pp.4825-4835, 2013. ,
DOI : 10.1158/0008-5472.CAN-04-1626
Unravelling mechanisms of p53-mediated tumour suppression, Nature Reviews Cancer, vol.60, issue.5, pp.359-370, 2014. ,
DOI : 10.1038/onc.2009.423
Clinical pharmacology of dipeptidyl peptidase 4 inhibitors indicated for the treatment of type 2 diabetes mellitus, Clinical and Experimental Pharmacology and Physiology, vol.56, issue.Suppl. 3, pp.999-1024, 2015. ,
DOI : 10.1007/s00125-012-2827-3
Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas, Diabetes, Obesity and Metabolism, vol.36, issue.4, pp.333-347, 2016. ,
DOI : 10.2337/dc13-0356
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death, Cell, vol.149, issue.5, pp.1060-1072, 2012. ,
DOI : 10.1016/j.cell.2012.03.042
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition, Nature Chemical Biology, vol.339, issue.1, pp.91-98, 2017. ,
DOI : 10.1093/nar/gni137
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells, Cancer Cell, vol.3, issue.3, pp.285-296, 2003. ,
DOI : 10.1016/S1535-6108(03)00050-3
Cardiovascular effects of DPP-4 inhibition: Beyond GLP-1, Vascular Pharmacology, vol.55, issue.1-3, pp.10-16, 2011. ,
DOI : 10.1016/j.vph.2011.05.001
Molecular Genetics of Colorectal Cancer, Annual Review of Pathology: Mechanisms of Disease, vol.6, issue.1, pp.479-507, 2011. ,
DOI : 10.1146/annurev-pathol-011110-130235
Precision medicine for cancer with next-generation functional diagnostics, Nature Reviews Cancer, vol.33, issue.12, pp.747-756, 2015. ,
DOI : 10.1177/2168479015570330
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970460
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice, Nature Cell Biology, vol.16, issue.12, pp.1180-1191, 2014. ,
DOI : 10.4049/jimmunol.1202975
Cytoplasmic functions of the tumour suppressor p53, Nature, vol.4, issue.7242, pp.1127-1130, 2009. ,
DOI : 10.4161/auto.6730
The role of CD26/dipeptidyl peptidase IV in cancer, Frontiers in Bioscience, vol.13, issue.13, pp.1634-1645, 2008. ,
DOI : 10.2741/2787
Autophagy promotes ferroptosis by degradation of ferritin, Autophagy, vol.12, issue.8, pp.1425-1428, 2016. ,
DOI : 10.1038/onc.2015.32
Colon cancer and apoptosis, The American Journal of Surgery, vol.191, issue.4, pp.517-526, 2006. ,
DOI : 10.1016/j.amjsurg.2005.11.009
Regulation of Cellular Metabolism and Hypoxia by p53, Cold Spring Harbor Perspectives in Medicine, vol.6, issue.7, 2016. ,
DOI : 10.1101/cshperspect.a026146
Context-dependent effects of dipeptidyl peptidase 4 inhibitors, Current Opinion in Nephrology and Hypertension, vol.26, pp.83-90, 2017. ,
DOI : 10.1097/MNH.0000000000000303
gene impairs p53 tumor suppressor function in a mouse model, Genes & Development, vol.30, issue.8, pp.918-930, 2016. ,
DOI : 10.1101/gad.275891.115
Ferroptosis as a p53-mediated activity during tumour suppression, Nature, vol.29, issue.7545, pp.57-62, 2015. ,
DOI : 10.1038/onc.2009.427
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455927
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis, Nature Chemical Biology, vol.26, issue.1, pp.81-90, 2017. ,
DOI : 10.1093/bioinformatics/btl485
Drugging the p53 pathway: understanding the route to clinical efficacy, Nature Reviews Drug Discovery, vol.13, issue.4, pp.217-236, 2014. ,
DOI : 10.1038/nrd4236
Prognostic Significance of CD26 in Patients with Colorectal Cancer, PLoS ONE, vol.183, issue.5, p.98582, 2014. ,
DOI : 10.1371/journal.pone.0098582.t004
Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence, Cell, vol.149, issue.6, pp.1269-1283, 2012. ,
DOI : 10.1016/j.cell.2012.04.026
Synchronized renal tubular cell death involves ferroptosis, Proc. Natl. Acad. Sci. USA 111, pp.16836-16841, 2014. ,
DOI : 10.1126/science.1172308
URL : http://www.pnas.org/content/111/47/16836.full.pdf
Dipeptidyl peptidase-4 (DPP-4): Localization and activity in human and rodent islets, Biochemical and Biophysical Research Communications, vol.453, issue.3, pp.398-404, 2014. ,
DOI : 10.1016/j.bbrc.2014.09.096
Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib, International Journal of Cancer, vol.1527, issue.112, pp.1732-1742, 2013. ,
DOI : 10.1016/S0304-4165(01)00163-5
The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells, Cancer Letters, vol.356, issue.2, pp.971-977, 2015. ,
DOI : 10.1016/j.canlet.2014.11.014
??-Tocopherol Increases the Intracellular Glutathione Level in HaCaT Keratinocytes, Free Radical Research, vol.36, issue.6, pp.705-709, 2002. ,
DOI : 10.1080/10715760210873
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection, The Journal of Experimental Medicine, vol.265, issue.4, pp.555-568, 2015. ,
DOI : 10.4049/jimmunol.177.2.852
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387287
p53 mutations in cancer, Nature Cell Biology, vol.19, issue.1, pp.2-8, 2013. ,
DOI : 10.1038/sj.onc.1201857
Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses, Proc. Natl. Acad. Sci. USA, pp.6806-6812, 2016. ,
A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer, Cell Stem Cell, vol.6, issue.6, pp.603-615, 2010. ,
DOI : 10.1016/j.stem.2010.04.001
p53 as a Regulator of Lipid Metabolism in Cancer, International Journal of Molecular Sciences, vol.7, issue.12, p.2074, 2016. ,
DOI : 10.1158/0008-5472.CAN-10-4652
The Role of p53 in Metabolic Regulation, Genes & Cancer, vol.2, issue.4, pp.385-391, 2011. ,
DOI : 10.1177/1947601911409738
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism, Proc. Natl. Acad. Sci. USA, pp.1433-1438, 2011. ,
DOI : 10.1016/j.molcel.2009.04.029
Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death, Frontiers in Oncology, vol.19, p.131, 2015. ,
DOI : 10.1158/1078-0432.CCR-13-0850
Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models, Journal of the American Chemical Society, vol.136, issue.12, pp.4551-4556, 2014. ,
DOI : 10.1021/ja411006a
URL : http://doi.org/10.1021/ja411006a
Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells, Hepatology, vol.22, issue.1, pp.173-184, 2016. ,
DOI : 10.1016/j.jnutbio.2010.03.011
Cloning and functional expression of the T cell activation antigen CD26, J. Immunol, vol.149, pp.481-486, 1992. ,
Murine Double Minute-2 Prevents p53-Overactivation-Related Cell Death (Podoptosis) of Podocytes, Journal of the American Society of Nephrology, vol.26, issue.7, pp.1513-1523, 2015. ,
DOI : 10.1681/ASN.2014040345
Protease signalling in cell death: caspases versus cysteine cathepsins, FEBS Letters, vol.57, issue.15, pp.2761-2767, 2007. ,
DOI : 10.1124/pr.57.2.6
p53 and metabolism, Nature Reviews Cancer, vol.40, issue.10, pp.691-700, 2009. ,
DOI : 10.4161/cc.7.7.5657
NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis, Science Translational Medicine, vol.385, issue.12, pp.334-351, 2016. ,
DOI : 10.1016/S0140-6736(14)62225-X
URL : http://arizona.openrepository.com/arizona/bitstream/10150/615617/1/aad6095_technical_edit_revised.pdf
Ferroptosis: process and function, Cell Death and Differentiation, vol.5, issue.3, pp.369-379, 2016. ,
DOI : 10.1038/sj.cdd.4401724
URL : http://www.nature.com/cdd/journal/v23/n3/pdf/cdd2015158a.pdf
Nuclear Localization of CD26 Induced by a Humanized Monoclonal Antibody Inhibits Tumor Cell Growth by Modulating of POLR2A Transcription, PLoS ONE, vol.141, issue.4, 2013. ,
DOI : 10.1371/journal.pone.0062304.s010
Ferroptosis: Death by Lipid Peroxidation, Trends in Cell Biology, vol.26, issue.3, pp.165-176, 2016. ,
DOI : 10.1016/j.tcb.2015.10.014
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764384
Regulation of Ferroptotic Cancer Cell Death by GPX4, Cell, vol.156, issue.1-2, pp.317-331, 2014. ,
DOI : 10.1016/j.cell.2013.12.010
The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents, Molecular & Cellular Oncology, vol.77, issue.4, 2015. ,
DOI : 10.1038/nri3743
Identification of ACSL4 as a biomarker and contributor of ferroptosis, Biochemical and Biophysical Research Communications, vol.478, issue.3, pp.1338-1343, 2016. ,
DOI : 10.1016/j.bbrc.2016.08.124
An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: Potential implications in cardiovascular disease, Atherosclerosis, vol.226, issue.2, pp.305-314, 2013. ,
DOI : 10.1016/j.atherosclerosis.2012.09.012
HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells, Cancer Research, vol.77, issue.8, pp.2064-2077, 2017. ,
DOI : 10.1158/0008-5472.CAN-16-1979