What is immune privilege (not)? Trends in immunology 28, pp.12-18, 2007. ,
Structural and functional features of central nervous system lymphatic vessels, Nature, vol.14, issue.7560, pp.337-341, 2015. ,
DOI : 10.1097/00019052-200106000-00006
Systemic inflammation and microglial activation: systematic review of animal experiments, Journal of Neuroinflammation, vol.94, issue.1, pp.1-13, 2015. ,
DOI : 10.1016/j.nlm.2010.04.001
Microbes' roadmap to neurons, Nature Reviews Neuroscience, vol.52, issue.6, pp.345-357, 2011. ,
DOI : 10.1002/(SICI)1096-9071(199708)52:4<362::AID-JMV3>3.0.CO;2-#
Inflammation and Stroke: Putative Role for Cytokines, Adhesion Molecules and iNOS in Brain Response to Ischemia, Brain Pathology, vol.25, issue.3, pp.95-112, 2000. ,
DOI : 10.1212/WNL.52.2.273
Mechanisms of microbial traversal of the blood???brain barrier, Nature Reviews Microbiology, vol.74, issue.8, pp.625-634, 2008. ,
DOI : 10.1016/S0002-9440(10)63734-0
Central nervous system involvement in experimental infection with Leishmania (Leishmania) amazonensis, American Journal of Tropical Medicine and Hygiene, vol.68, pp.661-665, 2003. ,
amastigotes in the central nervous system of a naturally infected dog, Journal of Veterinary Diagnostic Investigation, vol.42, issue.1, pp.142-14610, 2013. ,
DOI : 10.1086/498510
Neurological disease in human and canine leishmaniasis - clinical features and immunopathogenesis, Parasite Immunology, vol.95, issue.8, pp.385-39310, 2015. ,
DOI : 10.1016/j.rvsc.2013.08.004
Canine leishmaniosis ??? new concepts and insights on an expanding zoonosis: part one, Trends in Parasitology, vol.24, issue.7, pp.324-330, 2008. ,
DOI : 10.1016/j.pt.2008.04.001
Leishmaniasis Worldwide and Global Estimates of Its Incidence, PLoS ONE, vol.83, issue.30, p.35671, 2012. ,
DOI : 10.1371/journal.pone.0035671.s101
URL : http://doi.org/10.1371/journal.pone.0035671
Neurological disturbances in visceral leishmaniasis. The Journal of tropical medicine and hygiene 68, pp.248-250, 1965. ,
Neurologic changes in visceral leishmaniasis. The American journal of tropical medicine and hygiene 52, pp.149-154, 1995. ,
Is neurological involvement possible in visceral leishmaniasis in Kenya? Transactions of the, Royal Society of Tropical Medicine and Hygiene, vol.79, issue.872, 1985. ,
Neurological involvement in visceral leishmaniasis: case report, Revista da Sociedade Brasileira de Medicina Tropical, vol.79, issue.6, pp.743-745, 2010. ,
DOI : 10.1016/0035-9203(85)90143-9
URL : http://doi.org/10.1590/s0037-86822010000600031
Migration of Leishmania donovani amastigotes in cerebrospinal fluid, The Lancet, vol.346, issue.8968, pp.183-184, 1995. ,
DOI : 10.1016/S0140-6736(95)91242-8
Guillain-Barré syndrome as presenting manifestation of visceral leishmaniasis. The Lancet 338, pp.10-1016, 1991. ,
Guillain-Barre syndrome revealing visceral leishmaniasis in an immunocompetent woman], Revue neurologique, vol.159, pp.1046-1048, 2003. ,
Neurological manifestations of human leishmaniasis, Handbook of Clinical Neurology, vol.114, pp.193-198, 2013. ,
DOI : 10.1016/B978-0-444-53490-3.00013-3
Parasitic Central Nervous System Infections in Immunocompromised Hosts, Clinical Infectious Diseases, vol.40, issue.7, pp.115-12510, 2006. ,
DOI : 10.1086/428621
Leishmaniose visceral fatal associada ?? s??ndrome de imunodefici??ncia adquirida: relato de caso com achados necrosc??picos e estudo imuno-histoqu??mico, Revista da Sociedade Brasileira de Medicina Tropical, vol.3, issue.4, pp.245-250, 1994. ,
DOI : 10.1097/00002030-198903010-00009
: descriptions of 10 cases and a review of the literature, Journal of Small Animal Practice, vol.101, issue.3, pp.125-13810, 2017. ,
DOI : 10.1016/S0304-4017(01)00413-7
Estudo histol??gico e imunoistoqu??mico do sistema nervoso central de c??es naturalmente infectados por Leishmania (Leishmania) chagasi, Brazilian Journal of Veterinary Research and Animal Science, vol.44, issue.1, pp.5-11, 2007. ,
DOI : 10.11606/issn.1678-4456.bjvras.2007.26653
URL : http://doi.org/10.11606/issn.1678-4456.bjvras.2007.26653
Acute paraplegia associated with vasculitis in a dog with leishmaniasis, Journal of Small Animal Practice, vol.29, issue.4, pp.199-201, 2004. ,
DOI : 10.1136/vr.137.1.23
Intramedullary spinal cord mass presumptively associated with leishmaniasis in a dog, Journal of the American Veterinary Medical Association, vol.244, issue.2, pp.200-204, 2014. ,
DOI : 10.2460/javma.244.2.200
Estimation of blood content in the mouse brain by measurement of iron, Journal of Pharmacological Methods, vol.1, issue.3, pp.247-25310, 1978. ,
DOI : 10.1016/0160-5402(78)90054-2
Detection of Leishmania infantum amastigotes in canine choroid plexus, Veterinary Record, vol.139, issue.14, pp.346-347, 1996. ,
DOI : 10.1136/vr.139.14.346
Meningeal leishmaniosis induced by Leishmania infantum in naturally infected dogs, Veterinary Parasitology, vol.101, issue.1, pp.23-27, 2001. ,
DOI : 10.1016/S0304-4017(01)00413-7
Glial reactivity in dogs with visceral leishmaniasis: correlation with T??lymphocyte infiltration and with cerebrospinal fluid anti-Leishmania antibody titres, Cell and Tissue Research, vol.202, issue.Suppl B, pp.293-304, 2011. ,
DOI : 10.1007/978-3-642-79657-9_15
Estudo histol??gico e imunoistoqu??mico do sistema nervoso central de c??es naturalmente infectados por Leishmania (Leishmania) chagasi, Brazilian Journal of Veterinary Research and Animal Science, vol.44, issue.1, pp.5-11, 2007. ,
DOI : 10.11606/issn.1678-4456.bjvras.2007.26653
URL : http://doi.org/10.11606/issn.1678-4456.bjvras.2007.26653
Intracellular transport of Toxoplasma gondii through the blood???brain barrier, Journal of Neuroimmunology, vol.232, issue.1-2, pp.119-130, 2011. ,
DOI : 10.1016/j.jneuroim.2010.10.029
HIV-1 Infection of Bone Marrow Hematopoietic Progenitor Cells and Their Role in Trafficking and Viral Dissemination, PLoS Pathogens, vol.27, issue.1, p.1000215, 2008. ,
DOI : 10.1371/journal.ppat.1000215.g003
In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies, Science, vol.177, issue.8, pp.970-97410, 2008. ,
DOI : 10.4049/jimmunol.177.8.5269
Intravascular staining for discrimination of vascular and tissue leukocytes, Nature Protocols, vol.48, issue.1, pp.209-222005, 2014. ,
DOI : 10.1084/jem.20101295
Chemokines, Immunity, vol.12, issue.2, pp.121-12780165, 2000. ,
DOI : 10.1016/S1074-7613(00)80165-X
URL : http://onlinelibrary.wiley.com/doi/10.1002/ijc.22024/pdf
Cytokines in inflammatory brain lesions: helpful and harmful, Trends in Neurosciences, vol.19, issue.8, pp.331-33810, 1996. ,
DOI : 10.1016/0166-2236(96)10047-3
Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases, Brain Research Reviews, vol.48, issue.1, pp.16-42, 2005. ,
DOI : 10.1016/j.brainresrev.2004.07.021
Leishmania infection and neuroinflammation: Specific chemokine profile and absence of parasites in the brain of naturally-infected dogs, Journal of Neuroimmunology, vol.289, pp.21-29004, 2015. ,
DOI : 10.1016/j.jneuroim.2015.10.004
Cerebral malaria: gamma-interferon redux. Frontiers in cellular and infection microbiology 4, p.113, 2014. ,
DOI : 10.3389/fcimb.2014.00113
URL : http://doi.org/10.3389/fcimb.2014.00113
in BALB/c Mice Resistant to Development of Toxoplasmic Encephalitis, Journal of Interferon & Cytokine Research, vol.30, issue.9, pp.653-6600119, 2009. ,
DOI : 10.1089/jir.2009.0119
Expression and Role of CXCL10 during the Encephalitic Stage of Experimental and Clinical African Trypanosomiasis, The Journal of Infectious Diseases, vol.200, issue.10, pp.1556-156510, 2009. ,
DOI : 10.1086/644597
MCP-3/CCL7 production by astrocytes: implications for SIV neuroinvasion and AIDS encephalitis, Journal of NeuroVirology, vol.193, issue.4, pp.146-15210, 2011. ,
DOI : 10.1084/jem.193.8.905
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086688
Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-7 through NF??B and MAPK dependent pathways in rat astrocytes, Brain Research, vol.1287, pp.47-57081, 2009. ,
DOI : 10.1016/j.brainres.2009.06.081
Matrix metalloproteinases in neuroinflammation, Glia, vol.2, issue.3, pp.279-291, 2002. ,
DOI : 10.1212/WNL.53.7.1397
Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria, Laboratory Investigation, vol.278, issue.9, pp.873-888, 2006. ,
DOI : 10.4049/jimmunol.175.11.7642
Canine cerebral leishmaniasis: Potential role of matrix metalloproteinase-2 in the development of neurological disease, Veterinary Immunology and Immunopathology, vol.148, issue.3-4, pp.260-266, 2012. ,
DOI : 10.1016/j.vetimm.2012.05.007
Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3, Science, vol.289, issue.5482, pp.1202-1206, 2000. ,
DOI : 10.1126/science.289.5482.1202
Interferon Gamma in Leishmaniasis, Frontiers in Immunology, vol.4, issue.103389, p.156, 2013. ,
DOI : 10.3389/fimmu.2013.00156
URL : http://doi.org/10.3389/fimmu.2013.00156
Interleukin-1?? Induces Blood???Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes, PLoS ONE, vol.172, issue.10, 2014. ,
DOI : 10.1371/journal.pone.0110024.g006
URL : http://doi.org/10.1371/journal.pone.0110024
IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF-??, TGF-??1 and blood???brain barrier function, Journal of Neuroimmunology, vol.101, issue.2, pp.211-221, 1999. ,
DOI : 10.1016/S0165-5728(99)00148-4
Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys, Nature Immunology, vol.1, issue.5, pp.387-391, 2000. ,
DOI : 10.1038/80819
Transforming Growth Factor-Beta: Recent Advances on Its Role in Immune Tolerance, Methods Mol. Biol, vol.677, pp.303-338, 2011. ,
DOI : 10.1007/978-1-60761-869-0_21
Transforming Growth Factor-??1 Upregulates the Tight Junction and P-glycoprotein of Brain Microvascular Endothelial Cells, Cellular and Molecular Neurobiology, vol.24, issue.3, pp.491-497, 2004. ,
DOI : 10.1023/B:CEMN.0000022776.47302.ce
TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function, Journal of Neuroinflammation, vol.266, issue.2, pp.1-15, 2016. ,
DOI : 10.1016/j.expneurol.2015.02.013
URL : http://doi.org/10.1186/s12974-016-0503-0
IL-10 Deficiency Exacerbates the Brain Inflammatory Response to Permanent Ischemia without Preventing Resolution of the Lesion, Journal of Cerebral Blood Flow & Metabolism, vol.94, issue.12, p.155, 1955. ,
DOI : 10.1189/jlb.0313118
Astrocyte???endothelial interactions at the blood???brain barrier, Nature Reviews Neuroscience, vol.15, issue.1, pp.41-5310, 2006. ,
DOI : 10.1046/j.1469-7580.2002.00065.x
Gelatinase B: a tuner and amplifier of immune functions, Trends in Immunology, vol.22, issue.10, pp.571-579, 2001. ,
DOI : 10.1016/S1471-4906(01)02023-3
Enhanced Hematopoietic Activity Accompanies Parasite Expansion in the Spleen and Bone Marrow of Mice Infected with Leishmania donovani, Infection and Immunity, vol.68, issue.4, pp.1840-1848, 2000. ,
DOI : 10.1128/IAI.68.4.1840-1848.2000
Bone marrow derived elements and resident microglia in brain inflammation, Glia, vol.16, issue.1, pp.19-24, 1993. ,
DOI : 10.1016/S0171-2985(87)80083-9
A Natural Model of Leishmania major Infection Reveals a Prolonged "Silent" Phase of Parasite Amplification in the Skin Before the Onset of Lesion Formation and Immunity, The Journal of Immunology, vol.165, issue.2, pp.969-977, 2000. ,
DOI : 10.4049/jimmunol.165.2.969
Characterization of Metabolically Quiescent Leishmania Parasites in Murine Lesions Using Heavy Water Labeling, PLOS Pathogens, vol.298, issue.2, 2015. ,
DOI : 10.1371/journal.ppat.1004683.s009
Systemic Inflammation and the Brain: Novel Roles of Genetic, Molecular, and Environmental Cues as Drivers of Neurodegeneration, Frontiers in Cellular Neuroscience, vol.140, issue.Suppl, p.28, 2015. ,
DOI : 10.1016/j.cell.2010.02.015
Interleukin-10 and the pathogenesis of human visceral leishmaniasis, Trends in Immunology, vol.28, issue.9, pp.378-384, 2007. ,
DOI : 10.1016/j.it.2007.07.004
Liver-brain inflammation axis, AJP: Gastrointestinal and Liver Physiology, vol.301, issue.5, pp.749-761, 2011. ,
DOI : 10.1152/ajpgi.00184.2011
Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex, Journal of Neuroimmunology, vol.301, pp.65-73, 2016. ,
DOI : 10.1016/j.jneuroim.2016.11.003
Canine cerebral leishmaniasis: Potential role of matrix metalloproteinase-2 in the development of neurological disease, Veterinary Immunology and Immunopathology, vol.148, issue.3-4, pp.260-266, 2012. ,
DOI : 10.1016/j.vetimm.2012.05.007
Choroid plexus involvement in dogs with spontaneous visceral leishmaniasis: a histopathological investigation, Brazilian Journal of Veterinary Pathology, vol.2, pp.69-74, 2009. ,
Blood-brain barrier disruption during spontaneous canine visceral leishmaniasis, Parasite Immunology, vol.51, issue.12, pp.635-64510, 2015. ,
DOI : 10.1111/j.1748-5827.2009.00823.x
Occurrence of Leishmania infantum in the central nervous system of naturally infected dogs: Parasite load, viability, co-infections and histological alterations, PLOS ONE, vol.62, issue.4, 2017. ,
DOI : 10.1371/journal.pone.0175588.t001
Compartmentalized gene expression of toll-like receptors 2, 4 and 9 in the brain and peripheral lymphoid organs during canine visceral leishmaniasis, Parasite Immunology, vol.37, issue.12, pp.726-73110, 2014. ,
DOI : 10.1002/eji.200737744
A combined luciferase imaging and reverse transcription polymerase chain reaction assay for the study of Leishmania amastigote burden and correlated mouse tissue transcript fluctuations, Cellular Microbiology, vol.3, issue.1, pp.81-91, 2011. ,
DOI : 10.1615/CritRevImmunol.v26.i4.20
Imaging visceral leishmaniasis in real time with golden hamster model: Monitoring the parasite burden and hamster transcripts to further characterize the immunological responses of the host, Parasitology International, vol.66, issue.1, pp.933-939, 2017. ,
DOI : 10.1016/j.parint.2016.10.020
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes, Genome Biol, vol.3, p.34, 2002. ,
Quantitative Whole Body Biodistribution of Fluorescent-Labeled Agents by Non-Invasive Tomographic Imaging, PLoS ONE, vol.14, issue.6, 2011. ,
DOI : 10.1371/journal.pone.0020594.t001
Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR, Nucleic Acids Research, vol.30, issue.9, pp.36-36, 2002. ,
DOI : 10.1093/nar/30.9.e36