In vivo 1H magnetic resonance spectroscopy in young-adult daily marijuana users

Abstract : To date, there has been little work describing the neurochemical profile of young, heavy marijuana users. In this study, we examined 27 young-adult marijuana users and 26 healthy controls using single-voxel magnetic resonance spectroscopy on a 3 T scanner. The voxel was placed in the dorsal striatum, and estimated concentrations of glutamate + glutamine, myo-inositol, taurine + glucose, total choline and total N-acetylaspartate were examined between groups. There were no overall group effects, but two metabolites showed group by sex interactions. Lower levels of glutamate + glutamine (scaled to total creatine) were observed in female, but not male, marijuana users compared to controls. Higher levels of myo-inositol were observed in female users compared to female non-users and to males in both groups. Findings are discussed in relation to patterns of corticostriatal connectivity and function, in the context of marijuana abuse.
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Neuroimage-Clinical, Elsevier, 2013, 2, pp.581-589. 〈10.1016/j.nicl.2013.04.011〉
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Ryan L. Muetzel, Małgorzata Marjańska, Paul F. Collins, Mary P. Becker, Romain Valabrègue, et al.. In vivo 1H magnetic resonance spectroscopy in young-adult daily marijuana users. Neuroimage-Clinical, Elsevier, 2013, 2, pp.581-589. 〈10.1016/j.nicl.2013.04.011〉. 〈hal-01586935〉



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