Active gel model of amoeboid cell motility

Abstract : We develop a model of amoeboid cell motility based on active gel theory. Modeling the motile apparatus of a eukaryotic cell as a confined layer of finite length of poroelastic active gel permeated by a solvent, we first show that, due to active stress and gel turnover, an initially static and homogeneous layer can undergo a contractile-type instability to a polarized moving state in which the rear is enriched in gel polymer. This agrees qualitatively with motile cells containing an actomyosin-rich uropod at their rear. We find that the gel layer settles into a steadily moving, inhomogeneous state at long times, sustained by a balance between contractility and filament turnover. In addition, our model predicts an optimal value of the gel–substrate adhesion leading to maximum layer speed, in agreement with cell motility assays. The model may be relevant to motility of cells translocating in complex, confining environments that can be mimicked experimentally by cell migration through microchannels.
Type de document :
Article dans une revue
New Journal of Physics, Institute of Physics: Open Access Journals, 2013, 15, pp.025022. 〈10.1088/1367-2630/15/2/025022〉
Liste complète des métadonnées

Littérature citée [46 références]  Voir  Masquer  Télécharger

https://hal.sorbonne-universite.fr/hal-01586958
Contributeur : Gestionnaire Hal-Upmc <>
Soumis le : mercredi 13 septembre 2017 - 14:40:17
Dernière modification le : mercredi 21 mars 2018 - 18:57:52

Fichier

Callan-Jones_2013_New_J._Phys....
Publication financée par une institution

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Collections

Citation

Andrew Callan-Jones, Raphaël Voituriez. Active gel model of amoeboid cell motility. New Journal of Physics, Institute of Physics: Open Access Journals, 2013, 15, pp.025022. 〈10.1088/1367-2630/15/2/025022〉. 〈hal-01586958〉

Partager

Métriques

Consultations de la notice

152

Téléchargements de fichiers

33