The cholinergic hypothesis of geriatric memory dysfunction, Science, vol.217, issue.4558, pp.408-414, 1982. ,
DOI : 10.1126/science.7046051
The cholinergic hypothesis of Alzheimer's disease: a review of progress, Journal of Neurology, Neurosurgery & Psychiatry, vol.66, issue.2, pp.137-147, 1999. ,
DOI : 10.1136/jnnp.66.2.137
Alzheimer's disease: clinical trials and drug development, The Lancet Neurology, vol.9, issue.7, pp.702-716, 2010. ,
DOI : 10.1016/S1474-4422(10)70119-8
Assessing Therapeutic Efficacy in a Progressive Disease, CNS Drugs, vol.56, issue.4, pp.311-325, 2006. ,
DOI : 10.1176/ajp.147.8.1049
Do cholinergic therapies have disease-modifying effects in Alzheimer???s disease?, Alzheimer's & Dementia, vol.2, issue.2, pp.118-125, 2006. ,
DOI : 10.1016/j.jalz.2006.02.001
Do Cholinesterase Inhibitors Have Disease-Modifying Effects in Alzheimer??s Disease?, CNS Drugs, vol.10, issue.6, pp.85-91, 2001. ,
DOI : 10.2165/00023210-200115020-00001
Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe, Neurology, vol.74, issue.12, pp.956-96410, 2010. ,
DOI : 10.1212/WNL.0b013e3181d6476a
Randomized, Placebo-Controlled Trial of the Effects of Donepezil on Neuronal Markers and Hippocampal Volumes in Alzheimer???s Disease, American Journal of Psychiatry, vol.160, issue.11, pp.2003-2011, 2003. ,
DOI : 10.1176/appi.ajp.160.11.2003
Does Donepezil Treatment Slow the Progression of Hippocampal Atrophy in Patients With Alzheimer???s Disease?, American Journal of Psychiatry, vol.162, issue.4, pp.676-682676, 2005. ,
DOI : 10.1176/appi.ajp.162.4.676
Effects of donepezil on brain morphometric and metabolic changes in patients with Alzheimer's disease: A DARTEL-based VBM and 1H-MRS, Magnetic Resonance Imaging, vol.34, issue.7, pp.1008-1016025, 2016. ,
DOI : 10.1016/j.mri.2016.04.025
An MRI substudy of a donepezil clinical trial in mild cognitive impairment, Neurobiology of Aging, vol.32, issue.12, pp.2331-2341005, 2011. ,
DOI : 10.1016/j.neurobiolaging.2010.04.005
Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI, Neurobiology of Aging, vol.29, issue.9, pp.1285-1295, 2008. ,
DOI : 10.1016/j.neurobiolaging.2007.03.004
Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease, Alzheimer's & Dementia, vol.11, issue.9, p.3, 2015. ,
DOI : 10.1016/j.jalz.2014.10.003
Donepezil treatment of patients with MCI: A 48-week randomized, placebo-controlled trial, Neurology, vol.72, issue.18, pp.1555-1561, 2009. ,
DOI : 10.1212/01.wnl.0000344650.95823.03
Donepezil for mild cognitive impairment, Cochrane Database Syst Rev, vol.273, issue.3, pp.10-1002, 2006. ,
DOI : 10.1212/WNL.34.7.939
Reduced Regional Cortical Thickness Rate of Change in Donepezil-Treated Subjects With Suspected Prodromal Alzheimer???s Disease, The Journal of Clinical Psychiatry, vol.77, issue.12, pp.10-4088, 2016. ,
DOI : 10.4088/JCP.15m10413
URL : https://hal.archives-ouvertes.fr/hal-01388951
The cholinergic innervation of the human cerebral cortex, Prog Brain Res, vol.145, pp.67-7845004, 2004. ,
DOI : 10.1016/S0079-6123(03)45004-8
Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer's disease, Journal of Comparative Neurology, vol.313, issue.Suppl, pp.4124-414410, 2013. ,
DOI : 10.1002/cne.903130207
Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry, Neuroscience, vol.12, issue.3, pp.669-686, 1984. ,
DOI : 10.1016/0306-4522(84)90163-5
The cholinergic system in mild cognitive impairment and Alzheimer's disease: An in vivo MRI and DTI study, Human Brain Mapping, vol.42, issue.Part 3, pp.1349-1362, 2011. ,
DOI : 10.1016/j.neuroimage.2008.05.055
Atrophy of the Cholinergic Basal Forebrain Over the Adult Age Range and in Early Stages of Alzheimer's Disease, Biological Psychiatry, vol.71, issue.9, pp.805-813, 2012. ,
DOI : 10.1016/j.biopsych.2011.06.019
Reduction of Basal Forebrain Cholinergic System Parallels Cognitive Impairment in Patients at High Risk of Developing Alzheimer's Disease, Cerebral Cortex, vol.20, issue.7, pp.1685-169510, 2010. ,
DOI : 10.1093/cercor/bhp232
Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease, Neurobiology of Aging, vol.34, issue.4, pp.1210-1220018, 2013. ,
DOI : 10.1016/j.neurobiolaging.2012.10.018
Subregional Basal Forebrain Atrophy in Alzheimer's Disease: A Multicenter Study, J Alzheimers Dis, pp.10-3233, 2014. ,
Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease, Neurobiology of Aging, vol.11, issue.1, pp.3-13, 1990. ,
DOI : 10.1016/0197-4580(90)90056-6
Alzheimer's Disease Neuroimaging, I. Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer's pathology, Nat Commun, vol.7, pp.10-1038, 2016. ,
Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease, Neurobiology of Aging, vol.35, issue.3, pp.482-491029, 2014. ,
DOI : 10.1016/j.neurobiolaging.2013.09.029
Basal forebrain atrophy and cortical amyloid deposition in nondemented elderly subjects, Alzheimer's & Dementia, vol.10, issue.5, p.11, 2014. ,
DOI : 10.1016/j.jalz.2013.09.011
Basal forebrain atrophy correlates with amyloid ?? burden in Alzheimer's disease, NeuroImage: Clinical, vol.7, pp.105-113, 2015. ,
DOI : 10.1016/j.nicl.2014.11.015
Basal Forebrain Atrophy Contributes to Allocentric Navigation Impairment in Alzheimer???s Disease Patients, Frontiers in Aging Neuroscience, vol.42, issue.185, p.185, 2015. ,
DOI : 10.1016/j.neuroimage.2008.05.055
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS???ADRDA criteria, The Lancet Neurology, vol.6, issue.8, pp.734-74610, 2007. ,
DOI : 10.1016/S1474-4422(07)70178-3
Early neurone loss in Alzheimer???s disease: cortical or subcortical?, Acta Neuropathologica Communications, vol.10, issue.2, pp.10-1186, 2015. ,
DOI : 10.1016/S1474-4422(11)70156-9
Measurement of basal forebrain atrophy in Alzheimer's disease using MRI, Brain, vol.128, issue.11, pp.2626-2644, 2005. ,
DOI : 10.1093/brain/awh589
Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment, Cerebral Cortex, vol.26, issue.6, pp.2411-2426, 2016. ,
DOI : 10.1093/cercor/bhv062
Association of basal forebrain volumes and cognition in normal aging, Neuropsychologia, vol.53, pp.54-63, 2014. ,
DOI : 10.1016/j.neuropsychologia.2013.11.002
Effects of Cholinergic Enhancement on Visual Stimulation, Spatial Attention, and Spatial Working Memory, Neuron, vol.41, issue.6, pp.969-982, 2004. ,
DOI : 10.1016/S0896-6273(04)00145-X
Basal forebrain integrity and cognitive memory profile in healthy aging, Brain Research, vol.1308, pp.124-136048, 2010. ,
DOI : 10.1016/j.brainres.2009.10.048
The Role of the Basal Forebrain in Episodic Memory Retrieval: A Positron Emission Tomography Study, NeuroImage, vol.15, issue.3, pp.501-5080995, 2001. ,
DOI : 10.1006/nimg.2001.0995
Basal forebrain atrophy correlates with amyloid ?? burden in Alzheimer's disease, NeuroImage: Clinical, vol.7, pp.105-113, 2015. ,
DOI : 10.1016/j.nicl.2014.11.015
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia., BMJ, vol.2, issue.6150, pp.1457-1459, 1978. ,
DOI : 10.1136/bmj.2.6150.1457
Correlation between cortical plaque count and neuronal loss in the nucleus basalis in Alzheimer's disease, Neuroscience Letters, vol.48, issue.1, pp.81-85, 1984. ,
DOI : 10.1016/0304-3940(84)90292-1
Pre- and post-synaptic cortical cholinergic deficits are proportional to amyloid plaque presence and density at preclinical stages of Alzheimer???s disease, Acta Neuropathologica, vol.19, issue.Suppl 1, pp.49-6010, 2011. ,
DOI : 10.1016/j.neurobiolaging.2006.06.001
Atrophy of the Substantia innominata on Magnetic Resonance Imaging Predicts Response to Donepezil Treatment in Alzheimer???s Disease Patients, Dementia and Geriatric Cognitive Disorders, vol.16, issue.3, pp.119-12570998, 2003. ,
DOI : 10.1159/000070998
Predictors of cognitive decline and treatment response in a clinical trial on suspected prodromal Alzheimer's disease, Neuropharmacology, vol.108, pp.128-135005, 2016. ,
DOI : 10.1016/j.neuropharm.2016.02.005
MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers, Brain, vol.132, issue.4, pp.1067-107710, 2009. ,
DOI : 10.1093/brain/awp007
Effects of donepezil on cortical metabolic response to activation during 18FDG-PET in Alzheimer???s disease: a double-blind cross-over trial, Psychopharmacology, vol.11, issue.1, pp.86-9410, 2006. ,
DOI : 10.1212/WNL.56.3.408
Recovery of hippocampal network connectivity correlates with cognitive improvement in mild alzheimer's disease patients treated with donepezil assessed by resting-state fMRI, Journal of Magnetic Resonance Imaging, vol.61, issue.e159, pp.764-77310, 2011. ,
DOI : 10.1001/archneur.61.12.1852
Donepezil Treatment Stabilizes Functional Connectivity During Resting State and Brain Activity During Memory Encoding in Alzheimer???s Disease, Journal of Clinical Psychopharmacology, vol.33, issue.2, pp.199-20510, 2013. ,
DOI : 10.1097/JCP.0b013e3182825bfd
Effects of rivastigmine on visual attention in subjects with amnestic mild cognitive impairment: A serial functional MRI activation pilot-study, Psychiatry Research: Neuroimaging, vol.249, pp.84-90018, 2016. ,
DOI : 10.1016/j.pscychresns.2016.01.018
Human reticular formation: Cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons, The Journal of Comparative Neurology, vol.22, issue.4, pp.611-63310, 1989. ,
DOI : 10.1113/jphysiol.1967.sp008326
Donepezil Potentiates Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells, Journal of Pharmacological Sciences, vol.104, issue.4, pp.349-354, 2007. ,
DOI : 10.1254/jphs.FP0070563
??-Amyloid peptides as direct cholinergic neuromodulators: a missing link?, Trends in Neurosciences, vol.21, issue.1, pp.43-49, 1998. ,
DOI : 10.1016/S0166-2236(97)01144-2
Alzheimer's Disease, New England Journal of Medicine, vol.362, issue.4, pp.329-34410, 2010. ,
DOI : 10.1056/NEJMra0909142
A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines, The Scientific World Journal, vol.287, issue.24, p.756357, 2012. ,
DOI : 10.1023/A:1007614613771
Microglia receptors and their implications in the response to amyloid ?? for Alzheimer???s disease pathogenesis, Journal of Neuroinflammation, vol.11, issue.1, pp.10-1186, 2014. ,
DOI : 10.1186/1742-2094-8-11
in mechanisms of acetylcholinesterase inhibitors and memantine for the treatment of Alzheimer's disease, Neuroimmunol Neuroinflammation, vol.2, pp.274-280, 2015. ,
Anti-Inflammatory Action of Donepezil Ameliorates Tau Pathology, Synaptic Loss, and Neurodegeneration in a Tauopathy Mouse Model, Journal of Alzheimer's Disease, vol.22, issue.1, pp.295-30610, 2010. ,
DOI : 10.3233/JAD-2010-100681
Efficacy of lifestyle interventions on clinical and neuroimaging outcomes in elderly, Ageing Research Reviews, vol.25, pp.1-12, 2016. ,
DOI : 10.1016/j.arr.2015.11.003
Lifelong bilingualism and neural reserve against Alzheimer's disease: A review of findings and potential mechanisms, Behavioural Brain Research, vol.281, pp.9-15006, 2015. ,
DOI : 10.1016/j.bbr.2014.12.006
Omega-3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer???s Disease, BioMed Research International, vol.77, issue.4, pp.10-1155172801, 2015. ,
DOI : 10.1136/jnnp-2012-304792
ApoE genotype influences the biological effect of donepezil on APP metabolism in Alzheimer disease: evidence from a peripheral model, European Neuropsychopharmacology, vol.12, issue.3, pp.195-200, 2002. ,
DOI : 10.1016/S0924-977X(02)00013-5
Automatic segmentation of the hippocampus and the amygdala driven by hybrid constraints: Method and validation, NeuroImage, vol.46, issue.3, pp.749-761, 2009. ,
DOI : 10.1016/j.neuroimage.2009.02.013
URL : https://hal.archives-ouvertes.fr/hal-00805390
Symmetric diffeomorphic modeling of longitudinal structural MRI, Frontiers in Neuroscience, vol.6, issue.197, p.197, 2012. ,
DOI : 10.3389/fnins.2012.00197
Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey, The Journal of Comparative Neurology, vol.8, issue.2, pp.170-197902140206, 1983. ,
DOI : 10.1177/26.1.413864
Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase, The Journal of Comparative Neurology, vol.7, issue.2, pp.216-24010, 1988. ,
DOI : 10.1177/34.11.2430009
Subregional basal forebrain atrophy in Alzheimer's disease: a multicenter study, J Alzheimers Dis, vol.40, pp.687-70010, 2014. ,
19 Lyon 1 university, Hospices Civils de Lyon, hôpital neurologique, service de neurologie D, 17 Centre Mémoire/Centre de Recherche Clinique ? Gérontopôle, Hôpital Casselardit ,