A. Mombelli, Periodontitis as an infectious disease: specific features and their implications, Oral Diseases, vol.32, issue.s1, pp.6-10, 2003.
DOI : 10.1902/jop.1998.69.10.1085

G. Hajishengallis, The inflammophilic character of the periodontitis-associated microbiota, Molecular Oral Microbiology, vol.108, issue.6, pp.248-57, 2014.
DOI : 10.1073/pnas.1019270108

F. Trindade, F. Oppenheim, E. Helmerhorst, F. Amado, P. Gomes et al., Uncovering the molecular networks in periodontitis, PROTEOMICS - Clinical Applications, vol.47, issue.9-10, pp.9-10748, 2014.
DOI : 10.1111/j.1600-0765.2011.01445.x

L. Nibali, Aggressive Periodontitis: microbes and host response, who to blame?, Virulence, vol.6, issue.1, pp.223-231, 2015.
DOI : 10.1111/eos.12080

URL : http://www.tandfonline.com/doi/pdf/10.4161/21505594.2014.986407?needAccess=true

D. Bourgeois, P. Bouchard, and C. Mattout, Epidemiology of periodontal status in dentate adults in France, 2002?2003, Journal of Periodontal Research, vol.83, issue.3, pp.219-246, 2002.
DOI : 10.1034/j.1600-051x.2000.027005308.x

P. Eke, B. Dye, L. Wei, G. Slade, G. Thornton-evans et al., Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012, Journal of Periodontology, vol.86, issue.5, pp.611-633, 2015.
DOI : 10.1902/jop.2015.140520

M. Costalonga and M. Herzberg, The oral microbiome and the immunobiology of periodontal disease and caries, Immunology Letters, vol.162, issue.2, pp.22-38, 2014.
DOI : 10.1016/j.imlet.2014.08.017

M. Listgarten, The role of dental plaque in gingivitis and periodontitis, Journal of Clinical Periodontology, vol.1, issue.8, pp.485-492, 1988.
DOI : 10.1902/jop.1959.30.1.7

Y. Jiao, M. Hasegawa, and N. Inohara, The Role of Oral Pathobionts in Dysbiosis during Periodontitis Development, Journal of Dental Research, vol.57, issue.6, pp.539-585, 2014.
DOI : 10.1016/j.cell.2010.01.022

V. Lazar, C. Saviuc, and M. Chifiriuc, Periodontitis and Periodontal Disease - Innovative Strategies for Reversing the Chronic Infectious and Inflammatory Condition by Natural Products, Current Pharmaceutical Design, vol.22, issue.2, pp.230-237, 2016.
DOI : 10.2174/138161282202151221124307

V. Sousa, N. Mardas, B. Farias, A. Petrie, I. Needleman et al., A systematic review of implant outcomes in treated periodontitis patients, Clinical Oral Implants Research, vol.19, issue.7, pp.787-844, 2016.
DOI : 10.1016/0022-3913(90)90177-E

F. Scannapieco and A. Cantos, Oral inflammation and infection, and chronic medical diseases: implications for the elderly, Periodontology 2000, vol.41, issue.Suppl. 14, pp.153-75, 2000.
DOI : 10.1111/jcpe.12247

R. Martin-cabezas, N. Seelam, C. Petit, K. Agossa, S. Gaertner et al., Association between periodontitis and arterial hypertension: A systematic review and meta-analysis, American Heart Journal, vol.180, pp.98-112, 2016.
DOI : 10.1016/j.ahj.2016.07.018

W. Edgar, Saliva: its secretion, composition and functions, British Dental Journal, vol.172, issue.8, pp.305-317, 1992.
DOI : 10.1038/sj.bdj.4807861

L. Schenkels, E. Veerman, and A. Amerongen, Biochemical Composition of Human Saliva in Relation To Other Mucosal Fluids, Critical Reviews in Oral Biology & Medicine, vol.6, issue.2, pp.161-75, 1995.
DOI : 10.1016/0006-291X(92)90557-2

S. Humphrey and R. Williamson, A review of saliva: Normal composition, flow, and function, The Journal of Prosthetic Dentistry, vol.85, issue.2, pp.162-171, 2001.
DOI : 10.1067/mpr.2001.113778

N. Segata, S. Haake, P. Mannon, K. Lemon, L. Waldron et al., Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples, Genome Biology, vol.13, issue.6
DOI : 10.1371/journal.pone.0027310

A. Estreicher, A. Broggiato, P. Duroux, E. Andersen, and G. Cimasoni, Low molecular-weight proteins in human gingival crevicular fluid, Archives of Oral Biology, vol.41, issue.8-9, pp.8-9733, 1996.
DOI : 10.1016/S0003-9969(96)00076-3

W. Giannobile, Salivary diagnostics for periodontal diseases, The Journal of the American Dental Association, vol.143, pp.6-11, 2012.
DOI : 10.14219/jada.archive.2012.0341

H. Range, T. Leger, C. Huchon, C. Ciangura, D. Diallo et al., Salivary proteome modifications associated with periodontitis in obese patients, Journal of Clinical Periodontology, vol.148, issue.9, pp.799-806, 2012.
DOI : 10.1016/S0021-9150(99)00463-3

URL : https://hal.archives-ouvertes.fr/hal-00763783

A. Yamada-nosaka, S. Fukutomi, S. Uemura, T. Hashida, M. Fujishita et al., Preliminary nuclear magnetic resonance studies on human saliva, Archives of Oral Biology, vol.36, issue.9, pp.697-7010003, 1991.
DOI : 10.1016/0003-9969(91)90025-P

M. Grootveld and C. Silwood, 1H NMR analysis as a diagnostic probe for human saliva, Biochemical and Biophysical Research Communications, vol.329, issue.1, pp.1-5, 2005.
DOI : 10.1016/j.bbrc.2005.01.112

H. Bertram, N. Eggers, and N. Eller, Potential of Human Saliva for Nuclear Magnetic Resonance-Based Metabolomics and for Health-Related Biomarker Identification, Analytical Chemistry, vol.81, issue.21, pp.9188-93, 2009.
DOI : 10.1021/ac9020598

C. Santone, V. Dinallo, M. Paci, D. Ottavio, S. Barbato et al., Saliva metabolomics by NMR for the evaluation of sport performance, Journal of Pharmaceutical and Biomedical Analysis, vol.88, pp.441-447, 2014.
DOI : 10.1016/j.jpba.2013.09.021

B. Duchemann, M. Triba, D. Guez, M. Rzeznik, P. Savarin et al., Nuclear magnetic resonance spectroscopic analysis of salivary metabolome in sarcoidosis, Sarcoidosis Vasc Diffus Lung Dis, vol.33, issue.1, pp.10-16, 2016.

S. Wallner-liebniann, L. Tenori, A. Mazzoleni, M. Dieber-rotheneder, K. M. Hofmann et al., H NMR of Saliva Samples, Journal of Proteome Research, vol.15, issue.6, pp.1787-93, 2016.
DOI : 10.1021/acs.jproteome.5b01060

C. Silwood, E. Lynch, A. Claxson, and M. Grootveld, C NMR Spectroscopic Analysis of Human Saliva, Journal of Dental Research, vol.81, issue.6, pp.422-429, 2002.
DOI : 10.1016/0003-9969(91)90025-P

M. Aimetti, S. Cacciatore, A. Graziano, and L. Tenori, Metabonomic analysis of saliva reveals generalized chronic periodontitis signature, Metabolomics, vol.44, issue.3, pp.465-74, 2012.
DOI : 10.1016/j.oraloncology.2007.06.007

G. Armitage, Development of a Classification System for Periodontal Diseases and Conditions, Annals of Periodontology, vol.4, issue.1, pp.1-6, 1999.
DOI : 10.1902/annals.1999.4.1.1

S. Grossi, J. Zambon, A. Ho, G. Koch, R. Dunford et al., Assessment of Risk for Periodontal Disease. I. Risk Indicators for Attachment Loss, Journal of Periodontology, vol.65, issue.3, pp.260-267, 1994.
DOI : 10.1902/jop.1994.65.3.260

P. Eke, L. Wei, W. Borgnakke, G. Thornton-evans, X. Zhang et al., Periodontitis prevalence in adults ?????65??years of age, in the USA, Periodontology 2000, vol.181, issue.Suppl. 16, pp.76-95, 2000.
DOI : 10.1111/jcpe.12247

R. Page and P. Eke, Case Definitions for Use in Population-Based Surveillance of Periodontitis, Journal of Periodontology, vol.78, issue.7s, pp.1387-99, 2007.
DOI : 10.1902/jop.2007.060264

P. Eke, R. Page, L. Wei, G. Thornton-evans, and R. Genco, Update of the Case Definitions for Population-Based Surveillance of Periodontitis, Journal of Periodontology, vol.83, issue.12, pp.1449-54, 2012.
DOI : 10.1902/jop.2012.110664

E. Chaves, R. Wood, A. Jones, D. Newbold, M. Manwell et al., Relationship of "bleeding on probing" and "gingival index bleeding" as clinical parameters of gingival inflammation, Journal of Clinical Periodontology, vol.5, issue.2, pp.139-182, 1993.
DOI : 10.1902/jop.1984.55.12.684

O. Leary, T. Drake, R. Naylor, and J. , The Plaque Control Record, Journal of Periodontology, vol.43, issue.1, pp.38-4500182, 1972.
DOI : 10.1902/jop.1972.43.1.38

J. Ainamo and I. Bay, Problems and proposals for recording gingivitis and plaque, Int Dent J. Epub, vol.2512, issue.4, pp.229-3501, 1975.

N. Lang, R. Adler, A. Joss, and S. Nyman, Absence of bleeding on probing An indicator of periodontal stability, Journal of Clinical Periodontology, vol.45, issue.10, pp.714-735, 1990.
DOI : 10.1902/jop.1974.45.8.601

N. Lang, A. Joss, T. Orsanic, F. Gusberti, and B. Siegrist, Bleeding on probing. A predictor for the progression of periodontal disease?, Journal of Clinical Periodontology, vol.10, issue.6, pp.590-596, 1986.
DOI : 10.1902/jop.1974.45.8.601

A. Hugoson and T. Jordan, Frequency-distribution of individuals aged 20?70 years according to severity of periodontal-disease. Community Dentistry and Oral Epidemiology, pp.187-92, 1982.

F. Savorani, G. Tomasi, and S. Engelsen, icoshift: A versatile tool for the rapid alignment of 1D NMR spectra, Journal of Magnetic Resonance, vol.202, issue.2, pp.190-202, 2009.
DOI : 10.1016/j.jmr.2009.11.012

F. Dieterle, A. Ross, G. Schlotterbeck, and H. Senn, H NMR Metabonomics, Analytical Chemistry, vol.78, issue.13, pp.4281-90, 2006.
DOI : 10.1021/ac051632c

M. Kambouchner, P. Levy, A. Nicholson, K. Schubel, E. Magois et al., Prognostic relevance of histological variants in nonspecific interstitial pneumonia, Histopathology, vol.168, issue.Suppl. 1, pp.549-60, 2014.
DOI : 10.1164/rccm.200301-137OC

B. Cuevas-cordoba and J. Santiago-garcia, Saliva: A Fluid of Study for OMICS, OMICS: A Journal of Integrative Biology, vol.18, issue.2, pp.87-97, 2014.
DOI : 10.1089/omi.2013.0064

T. Hanioka, M. Tanaka, K. Takaya, Y. Matsumori, and S. Shizukuishi, Pocket Oxygen Tension in Smokers and Non-Smokers With Periodontal Disease, Journal of Periodontology, vol.71, issue.4, pp.550-554, 2000.
DOI : 10.1902/jop.2000.71.4.550

M. Grant, R. Kolamunne, F. Lock, J. Matthews, I. Chapple et al., Oxygen tension modulates the cytokine response of oral epithelium to periodontal bacteria, Journal of Clinical Periodontology, vol.26, issue.12, pp.1039-1087, 2010.
DOI : 10.1038/bjc.1994.2

J. Almerich-silla, J. Montiel-company, S. Pastor, F. Serrano, M. Puig-silla et al., Oxidative Stress Parameters in Saliva and Its Association with Periodontal Disease and Types of Bacteria. Dis Markers, p.26494938, 2015.

A. Acquier, D. Couto-pita, A. Busch, L. Sanchez, and G. , Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis, Redox Report, vol.23, issue.3, pp.1-8
DOI : 10.1080/15216540252774694

C. Tsai, C. Tang, T. Tan, K. Chen, K. Liao et al., Subgingival microbiota in individuals with severe chronic periodontitis, Journal of Microbiology, Immunology and Infection, vol.2016
DOI : 10.1016/j.jmii.2016.04.007

URL : http://doi.org/10.1016/j.jmii.2016.04.007

R. Niederman, J. Zhang, and S. Kashket, Short-Chain Carboxylic-Acid-Stimulated, PMN-Mediated Gingival Inflammation, Critical Reviews in Oral Biology & Medicine, vol.8, issue.3, pp.269-90, 1997.
DOI : 10.1111/j.1399-302X.1997.tb00736.x

URL : http://journals.sagepub.com/doi/pdf/10.1177/10454411970080030301

H. Uematsu, N. Sato, M. Hossain, T. Ikeda, and E. Hoshino, Degradation of arginine and other amino acids by butyrate-producing asaccharolytic anaerobic Gram-positive rods in periodontal pockets, Archives of Oral Biology, vol.48, issue.6, pp.423-432, 2003.
DOI : 10.1016/S0003-9969(03)00031-1

M. Chang, Y. Tsai, Y. Chen, C. Chan, C. Huang et al., Butyrate induces reactive oxygen species production and affects cell cycle progression in human gingival fibroblasts, Journal of Periodontal Research, vol.83, issue.1, pp.66-73, 2013.
DOI : 10.1902/jop.2011.110420

T. Nishihara and T. Koseki, Microbial etiology of periodontitis, Periodontology 2000, vol.249, issue.1, pp.14-26, 2000.
DOI : 10.1084/jem.173.5.1281

L. Qiqiang, M. Huanxin, and G. Xuejun, Longitudinal study of volatile fatty acids in the gingival crevicular fluid of patients with periodontitis before and after nonsurgical therapy, Journal of Periodontal Research, vol.183, issue.Suppl 8, pp.740-749, 2012.
DOI : 10.1128/JB.183.12.3770-3783.2001

S. Socransky, A. Haffajee, M. Cugini, C. Smith, and R. Kent, Microbial complexes in subgingival plaque, Journal of Clinical Periodontology, vol.11, issue.2, pp.134-178, 1998.
DOI : 10.1111/j.1600-051X.1993.tb00694.x

D. Klionsky, F. Abdalla, H. Abeliovich, R. Abraham, A. Acevedo-arozena et al., Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy, vol.4, issue.4, pp.445-544, 2012.
DOI : 10.4161/auto.6.4.12244

URL : https://hal.archives-ouvertes.fr/hal-01396896

S. Boris and C. Barbes, Role played by lactobacilli in controlling the population of vaginal pathogens, Microbes and Infection, vol.2, issue.5, pp.543-610, 2000.
DOI : 10.1016/S1286-4579(00)00313-0

H. Kuramitsu, X. He, R. Lux, M. Anderson, and W. Shi, Interspecies Interactions within Oral Microbial Communities, Microbiology and Molecular Biology Reviews, vol.71, issue.4, pp.653-18063722, 2007.
DOI : 10.1128/MMBR.00024-07

URL : http://mmbr.asm.org/content/71/4/653.full.pdf

N. Acid, Acid-Dependent Activities of Probiotic Lactobacilli against Salmonella enterica Serovar Typhimurium Applied and Environmental Microbiology, pp.6008-6021, 2005.

E. Pessione, Lactic acid bacteria contribution to gut microbiota complexity: lights and shadows, Frontiers in Cellular and Infection Microbiology, vol.2, issue.86, p.22919677, 2012.
DOI : 10.3389/fcimb.2012.00086

URL : http://journal.frontiersin.org/article/10.3389/fcimb.2012.00086/pdf

T. Pessi, Y. Sutas, H. Hurme, and E. Isolauri, Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.133, issue.12, pp.1804-1812, 2000.
DOI : 10.1046/j.1365-2222.1998.00449.x

H. Nam, K. Whang, and Y. Lee, Analysis of vaginal lactic acid producing bacteria in healthy women, Journal of Microbiology, vol.45, issue.6, pp.515-535, 2007.

R. Yang, M. Johnson, and R. B. , Novel method to extract large amounts of bacteriocins from lactic-acid bacteria, Applied and Environmental Microbiology, vol.58, issue.10, pp.3355-3364, 1992.

H. Alakomi, E. Skytta, M. Saarela, T. Mattila-sandholm, K. Latva-kala et al., Lactic Acid Permeabilizes Gram-Negative Bacteria by Disrupting the Outer Membrane, Applied and Environmental Microbiology, vol.66, issue.5, pp.2001-2006, 2000.
DOI : 10.1128/AEM.66.5.2001-2005.2000

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC101446/pdf

X. He, Y. Tian, L. Guo, R. Lux, D. Zusman et al., Oral-Derived Bacterial Flora Defends Its Domain by Recognizing and Killing Intruders???A Molecular Analysis Using Escherichia coli as a Model Intestinal Bacterium, Microbial Ecology, vol.32, issue.3, pp.655-64, 2010.
DOI : 10.1128/jb.170.9.4415-4419.1988

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954290

P. Koll-klais, R. Mandar, E. Leibur, H. Marcotte, L. Hammarstrom et al., Oral lactobacilli in chronic periodontitis and periodontal health: species composition and antimicrobial activity, Oral Microbiology and Immunology, vol.23, issue.6, pp.354-61, 2005.
DOI : 10.1046/j.1365-2672.2000.01027.x

S. Kageyama, T. Takeshita, M. Asakawa, Y. Shibata, K. Takeuchi et al., Relative abundance of total subgingival plaque-specific bacteria in salivary microbiota reflects the overall periodontal condition in patients with periodontitis, PLOS ONE, vol.85, issue.6, pp.174782-28369125, 2017.
DOI : 10.1371/journal.pone.0174782.s010