Cytotoxic indole alkaloids from Pseudovibrio denitrificans BBCC725
Abstract
In this study, we investigated a culture supernatant of a Pseudovibrio denitrificans strain isolated from sea water. Five indole alkaloids were isolated from this culture. These include four known compounds, arundine (1), vibrindole A (2), 1,1,1-tris(indol-3-yl)methane (3), 7,7-bis(indol-3-yl)-p-cresol (4) and the new tetra(indol-3-yl)ethanone (5). Compound 5 showed interesting cytotoxic effect against L929 cells (EC50 = 7 µM) and A549 cells (EC50 = 8 µM).
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