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L. We, S. Barbero-for-sgo2-antibody, D. J. Taylor, H. Baker, M. Yu et al., Sorger provided the Mps1?N strain We Ioanna Leontiou and Khaled Hached for preliminary experiments, and Vincent Galy for advice on spinning disc confocal microscopy We furthermore acknowledge help from our colleagues from the animal facility and administration (UMR7622), and Susanne Bolte and Jean-François Gilles from the IBPS imaging core facility for help with Confocal microscopy and 3D rendering. W.E.Y. is the recipient of a postdoctoral fellowship by ARC (Association de la Recherche Contre le Cancer), and I.B. of a 5 months visiting Predoctoral Mobility fellowship from the Ministerio de Economia y Competitividad , Spain (EEBB-I-14-08883). The lab of K.W. obtained financial support through grants by the Agence Nationale de la Recherche, Equipe FRM' by the Fondation de la Recherche Médicale (Equipe DEQ20160334921 to K.W.), the UPMC and CNRS. The group of J.A.S. obtained support through the research project BFU2014-53681-P from the Ministerio de Economia y Competitividad