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was supported by a Master grant from the Fondation pour la Recherche Médicale (FRM). C.H. was supported by an M.D. thesis grant by, are investigators at the Centre National pour la Recherche Scientifique (CNRS). A.H. was supported by a ''Poste Vert'' (Accueil de Chercheurs Etrangers) from the Institut National de la Santé et de la Recherche Médicale (INSERM) ,