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Article Dans Une Revue Angewandte Chemie International Edition Année : 2017

Phosphoribosyl Pyrophosphate: A Molecular Vestige of the Origin of Life on Minerals

Résumé

In this contribution, we report the formation under prebiotic conditions of phosphoribosyl pyrophosphate (PRPP) as a molecular precursor in the one-pot synthesis of a canonical nucleotide, namely adenosine monophosphate (AMP) from its building blocks (KH2PO4 or Pi, adenine, and d-ribose), on a fumed silica surface. The on-the-rocks approach([1]) has been successfully applied to the simultaneous phosphorylation and glycosylation of ribose. The one-pot formation mechanism of AMP involves a two-step pathway via an activated intermediate, namely PRPP, obtained by multiple ribose phosphorylations upon mild thermal activation.
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Dates et versions

hal-01652008 , version 1 (29-11-2017)

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Mariame Akouche, Maguy Jaber, Marie-Christine Maurel, Jean-François Lambert, Thomas Georgelin. Phosphoribosyl Pyrophosphate: A Molecular Vestige of the Origin of Life on Minerals. Angewandte Chemie International Edition, 2017, 56 (27), pp.7920 - 7923. ⟨10.1002/anie.201702633⟩. ⟨hal-01652008⟩
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