O. Abaan, E. Polley, S. Davis, Y. Zhu, S. Bilke et al., The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology, Cancer Research, vol.73, issue.14, pp.4372-4382, 2013.
DOI : 10.1158/0008-5472.CAN-12-3342

A. Agbor, A. Gö-ksenin, K. Lecompte, S. Hans, and Z. Pursell, Human Pol ??-dependent replication errors and the influence of mismatch repair on their correction, DNA Repair, vol.12, issue.11, pp.954-963, 2013.
DOI : 10.1016/j.dnarep.2013.08.012

A. Aksenova, K. Volkov, J. Maceluch, Z. Pursell, I. Rogozin et al., Mismatch Repair???Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase ??, PLoS Genetics, vol.278, issue.11, pp.2112494-2112502, 2010.
DOI : 10.1371/journal.pgen.1001209.s002

T. Albertson, M. Ogawa, J. Bugni, L. Hays, Y. Chen et al., DNA polymerase ?? and ?? proofreading suppress discrete mutator and cancer phenotypes in mice, Proceedings of the National Academy of Sciences, vol.273, issue.13, pp.17101-17104, 2009.
DOI : 10.1111/j.1742-4658.2006.05310.x

L. Alexandrov, S. Nik-zainal, D. Wedge, P. Campbell, and M. Stratton, Deciphering Signatures of Mutational Processes Operative in Human Cancer, Cell Reports, vol.3, issue.1, pp.246-259, 2013.
DOI : 10.1016/j.celrep.2012.12.008

L. Alexandrov, S. Nik-zainal, D. Wedge, S. Aparicio, S. Behjati et al., Signatures of mutational processes in human cancer, Nature, vol.27, issue.7463, pp.415-421, 2013.
DOI : 10.1093/bioinformatics/btr354

L. Alexandrov and M. Stratton, Mutational signatures: the patterns of somatic mutations hidden in cancer genomes, Current Opinion in Genetics & Development, vol.24, pp.52-60, 2014.
DOI : 10.1016/j.gde.2013.11.014

S. Banerjee and H. Flores-rozas, Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2-MSH6 complex, Nucleic Acids Research, vol.33, issue.4, pp.1410-1419, 2005.
DOI : 10.1093/nar/gki291

S. Barbari and P. Shcherbakova, Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy, DNA Repair, vol.56, pp.16-25, 2017.
DOI : 10.1016/j.dnarep.2017.06.003

A. Bhat, P. Andersen, Z. Qin, and X. W. , Rev3, the catalytic subunit of Pol??, is required for maintaining fragile site stability in human cells, Nucleic Acids Research, vol.25, issue.4, pp.2328-2339, 2013.
DOI : 10.1038/sj.emboj.7601251

N. Bhattacharyya, A. Ganesh, G. Phear, B. Richards, A. Skandalis et al., Molecular analysis of mutations in mutator colorectal carcinoma cell lines, Human Molecular Genetics, vol.4, issue.11, pp.2057-2064, 1995.
DOI : 10.1093/hmg/4.11.2057

C. Boland and A. Goel, Microsatellite Instability in Colorectal Cancer, Gastroenterology, vol.138, issue.6, pp.2073-2087, 2010.
DOI : 10.1053/j.gastro.2009.12.064

E. Bouffet, V. Larouche, B. Campbell, D. Merico, R. De-borja et al., Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency, Journal of Clinical Oncology, vol.34, issue.19, pp.2206-2211, 2016.
DOI : 10.1200/JCO.2016.66.6552

S. Briggs and I. Tomlinson, Germline and somatic polymerase ?? and ?? mutations define a new class of hypermutated colorectal and endometrial cancers, The Journal of Pathology, vol.202, issue.2, pp.148-153, 2013.
DOI : 10.1016/0022-2836(88)90552-9

B. Campbell, N. Light, D. Fabrizio, M. Zatzman, F. Fuligni et al., Comprehensive Analysis of Hypermutation in Human Cancer, Cell, vol.171, issue.5, pp.1042-1056, 2017.
DOI : 10.1016/j.cell.2017.09.048

C. Chang, G. Marra, D. Chauhan, H. Ha, D. Chang et al., Oxidative stress inactivates the human DNA mismatch repair system, American Journal of Physiology-Cell Physiology, vol.266, issue.1, p.12055083, 2001.
DOI : 10.1006/abbi.1995.1225

D. Church, S. Briggs, C. Palles, E. Domingo, S. Kearsey et al., DNA polymerase ?? and ?? exonuclease domain mutations in endometrial cancer, Human Molecular Genetics, vol.11, issue.14, pp.2820-2828, 2013.
DOI : 10.1186/gb-2010-11-8-r86

K. Cibulskis, M. Lawrence, S. Carter, A. Sivachenko, D. Jaffe et al., Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples, Nature Biotechnology, vol.27, issue.3, pp.213-219, 2013.
DOI : 10.1093/bioinformatics/btr446

D. Dennis, J. Mckay-fleisch, K. Eitzen, I. Dowsett, S. Kennedy et al., Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase d variant Scientific Reports 7:46535. DOI: https, p.28417960, 2017.

J. Drake, A constant rate of spontaneous mutation in DNA-based microbes., Proceedings of the National Academy of Sciences, vol.88, issue.16, pp.7160-7164, 1991.
DOI : 10.1073/pnas.88.16.7160

J. Drake, Contrasting mutation rates from specific-locus and long-term mutation-accumulation procedures DOI: https, G3: Genes|Genomes|Genetics, vol.2, pp.483-485, 2012.

C. Durno, C. Boland, S. Cohen, J. Dominitz, F. Giardiello et al., Recommendations on Surveillance and Management of Biallelic Mismatch Repair Deficiency (BMMRD) Syndrome, Journal of Pediatric Gastroenterology and Nutrition, vol.64, issue.5, pp.1605-1614, 2017.
DOI : 10.1097/MPG.0000000000001578

I. Fijalkowska and R. Schaaper, Mutants in the Exo I motif of Escherichia coli dnaQ: defective proofreading and inviability due to error catastrophe., Proceedings of the National Academy of Sciences, vol.93, issue.7, pp.2856-2861, 1996.
DOI : 10.1073/pnas.93.7.2856

E. Fox, J. Salk, and L. Loeb, Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer, Genome Medicine, vol.109, issue.1, p.26987311, 2016.
DOI : 10.1073/pnas.1208715109

G. Francia, S. Green, G. Bocci, S. Man, U. Emmenegger et al., Down-regulation of DNA mismatch repair proteins in human and murine tumor spheroids: implications for multicellular resistance to alkylating agents, Molecular Cancer Therapeutics, vol.4, issue.10, pp.1484-1494, 2005.
DOI : 10.1158/1535-7163.MCT-04-0214

R. Ganai, P. Osterman, and E. Johansson, Yeast DNA Polymerase ?? Catalytic Core and Holoenzyme Have Comparable Catalytic Rates, Journal of Biological Chemistry, vol.19, issue.6, pp.3825-3835, 2015.
DOI : 10.1038/nsmb.2851

W. Glaab and K. Tindall, Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects, Carcinogenesis, vol.18, issue.1, pp.1-8, 1997.
DOI : 10.1093/carcin/18.1.1

R. Goldsby, N. Lawrence, L. Hays, E. Olmsted, X. Chen et al., Defective DNA polymerase-?? proofreading causes cancer susceptibility in mice, Nature Medicine, vol.80, issue.6, pp.638-639, 2001.
DOI : 10.1002/(SICI)1097-0215(19990315)80:6<919::AID-IJC19>3.0.CO;2-U

R. Goldsby, L. Hays, X. Chen, E. Olmsted, W. Slayton et al., Nonlinear partial differential equations and applications: High incidence of epithelial cancers in mice deficient for DNA polymerase ?? proofreading, Proceedings of the National Academy of Sciences, vol.104, issue.3, pp.15560-15565, 2002.
DOI : 10.1016/S0092-8674(01)00220-3

M. Hahn, X. Wu, A. Li, T. Hahn, and G. Pfeifer, Relationship between Gene Body DNA Methylation and Intragenic H3K9me3 and H3K36me3 Chromatin Marks, PLoS ONE, vol.28, issue.4, p.21526191, 2011.
DOI : 10.1371/journal.pone.0018844.s006
URL : http://doi.org/10.1371/journal.pone.0018844

D. Hanahan and R. Weinberg, Hallmarks of Cancer: The Next Generation, Cell, vol.144, issue.5, pp.646-674, 2011.
DOI : 10.1016/j.cell.2011.02.013

N. Haradhvala, P. Polak, P. Stojanov, K. Covington, E. Shinbrot et al., Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair, Cell, vol.164, issue.3, pp.538-549, 2016.
DOI : 10.1016/j.cell.2015.12.050

J. Hawk, L. Stefanovic, J. Boyer, T. Petes, and R. Farber, Variation in efficiency of DNA mismatch repair at different sites in the yeast genome, Proceedings of the National Academy of Sciences, vol.19, issue.7, pp.8639-8643, 2005.
DOI : 10.1093/oxfordjournals.molbev.a004176

E. Heitzer and I. Tomlinson, Replicative DNA polymerase mutations in cancer, Current Opinion in Genetics & Development, vol.24, pp.107-113, 2014.
DOI : 10.1016/j.gde.2013.12.005

T. Helleday, S. Eshtad, and S. Nik-zainal, Mechanisms underlying mutational signatures in human cancers, Nature Reviews Genetics, vol.96, issue.9, pp.585-598, 2014.
DOI : 10.1038/nrc2998

E. Henninger and Z. Pursell, DNA polymerase ?? and its roles in genome stability, IUBMB Life, vol.74, issue.5, pp.339-351, 2014.
DOI : 10.1158/0008-5472.CAN-13-2892

A. Herr, M. Ogawa, N. Lawrence, L. Williams, J. Eggington et al., Mutator suppression and escape from replication error-induced extinction in yeast, PLoS Genetics, vol.7, p.22022273, 2011.

A. Herr, L. Williams, and B. Preston, Antimutator variants of DNA polymerases, Critical Reviews in Biochemistry and Molecular Biology, vol.131, issue.6, pp.548-570, 2011.
DOI : 10.1073/pnas.062502299

S. Hile, S. Shabashev, and K. Eckert, Tumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes? Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 743-744, pp.67-77, 2013.

F. Hodi, O. Day, S. Mcdermott, D. Weber, R. Sosman et al., Improved Survival with Ipilimumab in Patients with Metastatic Melanoma, New England Journal of Medicine, vol.363, issue.8, pp.711-723, 2010.
DOI : 10.1056/NEJMoa1003466

H. Hombauer, C. Campbell, C. Smith, A. Desai, and R. Kolodner, Visualization of Eukaryotic DNA Mismatch Repair Reveals Distinct Recognition and Repair Intermediates, Cell, vol.147, issue.5, pp.1040-1053, 2011.
DOI : 10.1016/j.cell.2011.10.025

M. Iwaizumi, S. Tseng-rogenski, and J. Carethers, Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 747-748, pp.19-27, 2013.

J. Jee, A. Rasouly, I. Shamovsky, Y. Akivis, S. Steinman et al., Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing, Nature, vol.85, issue.7609, pp.693-696, 2016.
DOI : 10.1007/BF00120324

J. Jiricny, Postreplicative mismatch repair. Cold Spring Harbor Perspectives in Biology 5:a012633. DOI: https, p.23545421, 2013.

C. Kandoth, N. Schultz, A. Cherniack, R. Akbani, Y. Liu et al., Integrated genomic characterization of endometrial carcinoma, Cancer Genome Atlas Research Network Nature, vol.497, pp.67-73, 2013.

D. Kane and P. Shcherbakova, A Common Cancer-Associated DNA Polymerase ?? Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading, Cancer Research, vol.74, issue.7, pp.1895-1901, 2014.
DOI : 10.1158/0008-5472.CAN-13-2892

S. Kennedy, E. Schultz, T. Chappell, B. Kohrn, G. Knowels et al., Volatility of Mutator Phenotypes at Single Cell Resolution, PLOS Genetics, vol.40, issue.4, p.25868109, 2015.
DOI : 10.1371/journal.pgen.1005151.s012

D. Korona, K. Lecompte, and Z. Pursell, The high fidelity and unique error signature of human DNA polymerase ??, Nucleic Acids Research, vol.19, issue.3, pp.1763-1773, 2011.
DOI : 10.1128/MCB.19.3.2000

T. Kunkel and D. Erie, DNA MISMATCH REPAIR, Annual Review of Biochemistry, vol.74, issue.1, pp.681-710, 2005.
DOI : 10.1146/annurev.biochem.74.082803.133243

E. Larson and J. Drummond, Is Inhibited by Adriamycin, Actinomycin D, and Nogalamycin, Journal of Biological Chemistry, vol.45, issue.13, pp.9775-9783, 2001.
DOI : 10.1016/S0092-8674(00)81621-9
URL : http://www.jbc.org/content/276/13/9775.full.pdf

D. Le, J. Uram, H. Wang, B. Bartlett, H. Kemberling et al., PD-1 Blockade in Tumors with Mismatch-Repair Deficiency, New England Journal of Medicine, vol.372, issue.26, pp.2509-2520, 2015.
DOI : 10.1056/NEJMoa1500596

H. Lee, E. Popodi, H. Tang, and P. Foster, Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing, Proceedings of the National Academy of Sciences, vol.26, issue.8, p.22991466, 2012.
DOI : 10.1016/j.tig.2010.05.003

G. Li, Mechanisms and functions of DNA mismatch repair, Cell Research, vol.62, issue.1, pp.85-98, 2008.
DOI : 10.1126/science.7761852

H. Li and R. Durbin, Fast and accurate short read alignment with Burrows-Wheeler transform, Bioinformatics, vol.9, issue.11, pp.1754-1760, 2009.
DOI : 10.1186/1471-2105-9-128

H. Li, Toward better understanding of artifacts in variant calling from high-coverage samples, Bioinformatics, vol.32, issue.20, pp.2843-2851, 2014.
DOI : 10.1038/nbt.2835

Y. Lu, N. Wajapeyee, M. Turker, and P. Glazer, Silencing of the DNA Mismatch Repair Gene MLH1 Induced by Hypoxic Stress in a Pathway Dependent on the Histone Demethylase LSD1, Cell Reports, vol.8, issue.2, pp.501-513, 2014.
DOI : 10.1016/j.celrep.2014.06.035

S. Lujan, J. Williams, Z. Pursell, A. Abdulovic-cui, A. Clark et al., Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity, PLoS Genetics, vol.8, issue.10, p.23071460, 2012.
DOI : 10.1371/journal.pgen.1003016.s006

S. Lujan, A. Clausen, A. Clark, H. Macalpine, D. Macalpine et al., Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition, Genome Research, vol.115, issue.11, pp.1751-1764, 2014.
DOI : 10.1534/genetics.110.120105

H. Lynch, T. Smyrk, P. Watson, S. Lanspa, J. Lynch et al., Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review, Gastroenterology, vol.104, issue.5, pp.1535-15490016, 1993.
DOI : 10.1016/0016-5085(93)90368-M

M. Lynch, Rate, molecular spectrum, and consequences of human mutation, Proceedings of the National Academy of Sciences, vol.416, issue.6881, pp.961-968, 2010.
DOI : 10.1038/416624a

A. Mckenna, M. Hanna, E. Banks, A. Sivachenko, K. Cibulskis et al., The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data, Genome Research, vol.20, issue.9, pp.1297-1303, 2010.
DOI : 10.1101/gr.107524.110

T. Mertz, S. Sharma, A. Chabes, and P. Shcherbakova, Colon cancer-associated mutator DNA polymerase ?? variant causes expansion of dNTP pools increasing its own infidelity, Proceedings of the National Academy of Sciences, vol.122, issue.1, pp.2467-2476, 2015.
DOI : 10.1073/pnas.0914857107

V. Mihaylova, R. Bindra, J. Yuan, D. Campisi, L. Narayanan et al., Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells, Molecular and Cellular Biology, vol.23, issue.9, pp.3265-3273, 2003.
DOI : 10.1128/MCB.23.9.3265-3273.2003

P. Modrich, Mechanisms in Eukaryotic Mismatch Repair, Journal of Biological Chemistry, vol.18, issue.41, pp.30305-30309, 1074.
DOI : 10.1016/j.cell.2006.05.039

A. Morrison, J. Bell, T. Kunkel, and A. Sugino, Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity., Proceedings of the National Academy of Sciences, vol.88, issue.21, pp.9473-9477, 1991.
DOI : 10.1073/pnas.88.21.9473

A. Morrison, A. Johnson, L. Johnston, and A. Sugino, Pathway correcting DNA replication errors in Saccharomyces cerevisiae, The EMBO journal, vol.12, pp.1467-1473, 1993.

A. Morrison and A. Sugino, The 3? ? 5? exonucleases of both DNA polymerases ? and ? participate in correcting errors of DNA replication in Saccharomyces cerevisiae, MGG Molecular & General Genetics, vol.60, issue.3, pp.289-296, 1007.
DOI : 10.1007/BF00280418

K. Negishi, D. Loakes, and R. Schaaper, Saturation of DNA mismatch repair and error catastrophe by a base analogue in Escherichia coli, Genetics, vol.161, pp.1363-1371, 2002.

N. Nicolay, R. Carter, S. Hatch, N. Schultz, R. Prevo et al., Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta, Carcinogenesis, vol.15, issue.11, pp.2026-2034, 2012.
DOI : 10.1158/1078-0432.CCR-08-1227

S. Nik-zainal, H. Davies, J. Staaf, M. Ramakrishna, D. Glodzik et al., Landscape of somatic mutations in 560 breast cancer whole-genome sequences, Nature, vol.14, issue.7605, pp.47-54, 2016.
DOI : 10.1093/bioinformatics/btq170
URL : https://hal.archives-ouvertes.fr/hal-01388447

S. Ohzeki, A. Tachibana, K. Tatsumi, and T. Kato, Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair, Carcinogenesis, vol.18, issue.6, pp.1127-1133, 1997.
DOI : 10.1093/carcin/18.6.1127

C. Palles, J. Cazier, K. Howarth, E. Domingo, A. Jones et al., Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas, Nature Genetics, vol.98, issue.2, pp.136-144, 2013.
DOI : 10.1093/bioinformatics/btp253

N. Papadopoulos, N. Nicolaides, Y. Wei, S. Ruben, K. Carter et al., Mutation of a mutL homolog in hereditary colon cancer, Science, vol.263, issue.5153, pp.1625-1629, 1994.
DOI : 10.1126/science.8128251

R. Parsons, G. Li, M. Longley, W. Fang, N. Papadopoulos et al., Hypermutability and mismatch repair deficiency in RER+ tumor cells, Cell, vol.75, issue.6, pp.1227-12360092, 1993.
DOI : 10.1016/0092-8674(93)90331-J

Y. Pavlov, S. Maki, H. Maki, and T. Kunkel, Correction: Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations, BMC Biology, vol.5, issue.1, pp.1741-7007, 2004.
DOI : 10.1186/1741-7007-5-27

G. Plotz, J. Raedle, A. Spina, C. Welsch, A. Stallmach et al., Evaluation of the MLH1 I219V alteration in DNA mismatch repair activity and ulcerative colitis, Inflammatory Bowel Diseases, vol.61, issue.5, pp.605-611, 2008.
DOI : 10.1002/1097-0142(20010615)91:12<2417::AID-CNCR1276>3.0.CO;2-U

C. Rago, B. Vogelstein, and F. Bunz, Genetic knockouts and knockins in human somatic cells, Nature Protocols, vol.225, issue.11, pp.2734-2746, 2007.
DOI : 10.1128/MCB.15.1.45

E. Rayner, I. Van-gool, C. Palles, S. Kearsey, T. Bosse et al., A panoply of errors: polymerase proofreading domain mutations in cancer, Nature Reviews Cancer, vol.3, issue.2, pp.71-81, 2016.
DOI : 10.1002/cam4.305

S. Roberts, M. Lawrence, L. Klimczak, S. Grimm, D. Fargo et al., An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers, Nature Genetics, vol.57, issue.9, pp.970-976, 2013.
DOI : 10.1016/j.dnarep.2007.07.002

W. Rosche and P. Foster, Determining Mutation Rates in Bacterial Populations, Methods, vol.20, issue.1, pp.4-17, 2000.
DOI : 10.1006/meth.1999.0901

A. Santin, S. Bellone, N. Buza, J. Choi, P. Schwartz et al., Regression of Chemotherapy-Resistant Polymerase ?? (POLE) Ultra-Mutated and MSH6 Hyper-Mutated Endometrial Tumors with Nivolumab, Clinical Cancer Research, vol.22, issue.23, pp.5682-5687, 2016.
DOI : 10.1158/1078-0432.CCR-16-1031

R. Schaaper and M. Radman, The extreme mutator effect of Escherichia coli mutD5 results from saturation of mismatch repair by excessive DNA replication errors, The EMBO journal, vol.8, pp.3511-3516, 1989.

S. Shah, S. Hile, and K. Eckert, Defective Mismatch Repair, Microsatellite Mutation Bias, and Variability in Clinical Cancer Phenotypes, Cancer Research, vol.70, issue.2, pp.431-4350008, 1158.
DOI : 10.1158/0008-5472.CAN-09-3049

P. Shcherbakova and Y. Pavlov, 3'?>5' exonucleases of DNA polymerases epsilon and delta correct base analog induced DNA replication errors on opposite DNA strands in Saccharomyces cerevisiae, Genetics, vol.142, pp.717-726, 1996.

P. Shcherbakova, Y. Pavlov, O. Chilkova, I. Rogozin, E. Johansson et al., Unique Error Signature of the Four-subunit Yeast DNA Polymerase ??, Journal of Biological Chemistry, vol.268, issue.44, pp.43770-43780, 2003.
DOI : 10.1073/pnas.91.15.6830

E. Shinbrot, E. Henninger, N. Weinhold, K. Covington, A. Gö-ksenin et al., Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication, Genome Research, vol.19, issue.11, pp.1740-1750, 2014.
DOI : 10.1016/j.mrfmmm.2014.01.003

A. Shlien, B. Campbell, R. De-borja, L. Alexandrov, D. Merico et al., Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers, Nature Genetics, vol.262, issue.3, pp.257-262, 2015.
DOI : 10.1101/gr.174789.114

M. Simon, L. Giot, and F. G. , The 3' to 5' exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication, The EMBO journal, vol.10, pp.2165-2170, 1991.

M. Stratton, Exploring the Genomes of Cancer Cells: Progress and Promise, Science, vol.464, issue.7291, pp.1553-1558, 2011.
DOI : 10.1038/nature08987

F. Supek and B. Lehner, Differential DNA mismatch repair underlies mutation rate variation across the human genome, Nature, vol.42, issue.7550, pp.81-84, 2015.
DOI : 10.2307/1939574

K. Tindall, W. Glaab, A. Umar, J. Risinger, M. Koi et al., Complementation of mismatch repair gene defects by chromosome transfer, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.402, issue.1-2, pp.15-22, 1016.
DOI : 10.1016/S0027-5107(97)00277-7

H. Tran, J. Keen, M. Kricker, M. Resnick, and D. Gordenin, Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants., Molecular and Cellular Biology, vol.17, issue.5, pp.2859-2865, 1997.
DOI : 10.1128/MCB.17.5.2859

P. Treuting, T. Albertson, and B. Preston, Case Series, Toxicologic Pathology, vol.1, issue.3, pp.476-485, 2010.
DOI : 10.1073/pnas.86.23.9412

K. Wang, M. Li, and H. Hakonarson, ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data, Nucleic Acids Research, vol.8, issue.1, p.20601685, 2010.
DOI : 10.1038/sj.ejhg.5200406

D. Wheeler and W. L. , From human genome to cancer genome: The first decade, Genome Research, vol.23, issue.7, pp.1054-1062, 2013.
DOI : 10.1101/gr.157602.113

L. Williams, A. Herr, and B. Preston, Emergence of DNA Polymerase ?? Antimutators That Escape Error-Induced Extinction in Yeast, Genetics, vol.193, issue.3, pp.751-770, 2013.
DOI : 10.1534/genetics.112.146910

L. Williams, L. Marjavaara, G. Knowels, E. Schultz, E. Fox et al., dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ?? variants, Proceedings of the National Academy of Sciences, vol.26, issue.4, pp.2457-2466, 2015.
DOI : 10.1186/1471-2105-11-141

K. Wimmer, C. Kratz, H. Vasen, O. Caron, C. Colas et al., Diagnostic criteria for constitutional mismatch repair deficiency syndrome: suggestions of the European consortium ???Care for CMMRD??? (C4CMMRD), Journal of Medical Genetics, vol.51, issue.6, pp.355-365
DOI : 10.1002/gcc.21966

W. Zahurancik, A. Baranovskiy, T. Tahirov, and Z. Suo, Comparison of the kinetic parameters of the truncated catalytic subunit and holoenzyme of human DNA polymerase ??, DNA Repair, vol.29, pp.16-22, 2015.
DOI : 10.1016/j.dnarep.2015.01.008

S. Zhao, M. Choi, J. Overton, S. Bellone, D. Roque et al., Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma, Proceedings of the National Academy of Sciences, vol.104, issue.50, pp.2916-2921, 2013.
DOI : 10.1073/pnas.0710052104

W. Zhou, Y. Chen, X. Liu, P. Chu, S. Loria et al., Expression of DNA translesion synthesis polymerase h in head and neck squamous cell cancer predicts resistance to gemcitabine and cisplatinbased chemotherapy, PLoS One, vol.8, pp.2437677-2437686, 2013.

H. Zhu, Z. Miao, M. Huang, J. Feng, Z. Zhang et al., Naphthalimides Induce G2 Arrest Through the ATM-Activated Chk2-Executed Pathway in HCT116 Cells, Neoplasia, vol.11, issue.11, pp.1226-1234, 2009.
DOI : 10.1593/neo.09986