J. Benichou, R. Benhamo, Y. Louzoun, and S. Efroni, Rep-Seq: uncovering the immunological repertoire through next-generation sequencing, Immunology, vol.37, issue.Suppl, pp.183-91, 2012.
DOI : 10.1093/nar/gkn838
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2011.03527.x/pdf

J. Cohen, J. Heijst, J. Glanville, and Y. Louzoun, Converging evolution leads to near maximal junction diversity through parallel mechanisms in B and T cell receptors, Phys Biol, vol.14, issue.4, p.45003, 2017.

J. Benichou, J. Glanville, E. Prak, R. Azran, T. Kuo et al., The Restricted DH Gene Reading Frame Usage in the Expressed Human Antibody Repertoire Is Selected Based upon its Amino Acid Content, The Journal of Immunology, vol.190, issue.11, pp.5567-77, 2013.
DOI : 10.4049/jimmunol.1201929
URL : http://www.jimmunol.org/content/jimmunol/190/11/5567.full.pdf

N. Pallarès, J. Frippiat, V. Giudicelli, and M. Lefranc, The Human Immunoglobulin Lambda Variable (IGLV) Genes and Joining (IGLJ) Segments, Experimental and Clinical Immunogenetics, vol.15, issue.1, pp.8-18, 1998.
DOI : 10.1159/000019054

K. Jackson, Y. Wang, B. Gaeta, W. Pomat, P. Siba et al., Divergent human populations show extensive shared IGK rearrangements in peripheral blood B cells, Immunogenetics, vol.16, issue.1, pp.3-14, 2012.
DOI : 10.1016/0167-5699(95)80009-3

C. Watson, K. Steinberg, T. Graves, R. Warren, M. Malig et al., Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity, Genes & Immunity, vol.2, issue.1, pp.24-34, 2015.
DOI : 10.1126/science.1072047

K. Hoi and G. Ippolito, Intrinsic bias and public rearrangements in the human immunoglobulin V?? light chain repertoire, Genes & Immunity, vol.7, issue.4, pp.271-277, 2013.
DOI : 10.1093/nar/gkn316

H. Brezinschek, R. Brezinschek, and P. Lipsky, Analysis of the heavy chain reper toire of human peripheral B cells using singlecell polymerase chain reaction, J Immunol, vol.155, pp.190-202, 1995.

R. Schelonka, J. Tanner, Y. Zhuang, G. Gartland, M. Zemlin et al., Categorical selection of the antibody repertoire in splenic B cells, European Journal of Immunology, vol.399, issue.4, pp.1010-1031, 2007.
DOI : 10.4049/jimmunol.172.1.625

J. Cox, I. Tomlinson, and G. Winter, A directory of human germ-line V?? segments reveals a strong bias in their usage, European Journal of Immunology, vol.342, issue.4, pp.827-863, 1994.
DOI : 10.1515/bchm3.1992.373.1.177

M. Yamada, R. Wasserman, B. Reichard, S. Shane, A. Caton et al., Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes, Journal of Experimental Medicine, vol.173, issue.2, pp.395-407, 1991.
DOI : 10.1084/jem.173.2.395
URL : http://jem.rupress.org/content/jem/173/2/395.full.pdf

J. Glanville, W. Zhai, J. Berka, D. Telman, G. Huerta et al., Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire, Proceedings of the National Academy of Sciences, vol.25, issue.17, pp.20216-20237, 2009.
DOI : 10.1093/nar/25.17.3389

Y. Louzoun, T. Friedman, L. Prak, E. Litwin, S. Weigert et al., Analysis of B cell receptor production and rearrangement, Seminars in Immunology, vol.14, issue.3, pp.169-90, 2002.
DOI : 10.1016/S1044-5323(02)00041-6

L. Prak, E. Monestier, M. Eisenberg, R. Russell, D. Nemazee et al., B cell receptor editing in tolerance and autoimmunity, Annals of the New York Academy of Sciences, vol.180, issue.1, pp.96-1211009, 1993.
DOI : 10.4049/jimmunol.180.9.6094

Y. Li, Y. Louzoun, and M. Weigert, Editing Anti-DNA B Cells by V??x, The Journal of Experimental Medicine, vol.9, issue.3, pp.337-383, 2004.
DOI : 10.3109/08830189609061758
URL : http://jem.rupress.org/content/jem/199/3/337.full.pdf

Y. Elhanati, Z. Sethna, Q. Marcou, C. Callan, T. Mora et al., Inferring processes underlying Bcell repertoire diversity, Philos Trans R Soc Lond B Biol Sci, vol.370, 2015.
DOI : 10.1098/rstb.2014.0243
URL : http://rstb.royalsocietypublishing.org/content/royptb/370/1676/20140243.full.pdf

Y. Elhanati, A. Murugan, C. Callan, T. Mora, and A. Walczak, Quantifying selection in immune receptor repertoires, Proceedings of the National Academy of Sciences, vol.111, issue.27, pp.9875-80, 2014.
DOI : 10.1073/pnas.0913939107
URL : http://www.pnas.org/content/111/27/9875.full.pdf

, Available from: https://www.ncbi.nlm.nih.gov/bioproject, 212030.

D. Wesemann, A. Portuguese, R. Meyers, M. Gallagher, K. Cluffjones et al., Microbial colonization influences early B-lineage development in the gut lamina propria, Nature, vol.2, issue.7465, pp.112-117, 2013.
DOI : 10.1101/gr.115428.110

J. Ye, N. Ma, T. Madden, and J. Ostell, IgBLAST: an immunoglobulin variable domain sequence analysis tool, Nucleic Acids Research, vol.113, issue.W1, pp.34-40, 2013.
DOI : 10.1172/JCI20255

V. Odegard and D. Schatz, Targeting of somatic hypermutation, Nature Reviews Immunology, vol.102, issue.8, pp.573-83, 2006.
DOI : 10.1182/blood-2002-12-3827

B. Kolaczkowski and J. Thornton, Performance of maximum parsimony and likelihood phylogenetics when evolution is heterogeneous, Nature, vol.13, issue.7011, pp.980-984, 2004.
DOI : 10.1080/106351501750435086

N. Saitou and M. Nei, The neighborjoining method: a new method for recon structing phylogenetic trees, Mol Biol Evol, vol.4, pp.406-431, 1987.

G. Liberman, J. Benichou, L. Tsaban, J. Glanville, and Y. Louzoun, Multi Step Selection in Ig H Chains is Initially Focused on CDR3 and Then on Other CDR Regions, Frontiers in Immunology, vol.4, 2013.
DOI : 10.3389/fimmu.2013.00274
URL : https://www.frontiersin.org/articles/10.3389/fimmu.2013.00274/pdf

G. Yaari, J. Benichou, V. Heiden, J. Kleinstein, S. Louzoun et al., The muta tion patterns in Bcell immunoglobulin receptors reflect the influence of selection acting at multiple timescales, Philos Trans R Soc Lond B Biol Sci, vol.370, 2015.

G. Liberman, J. Benichou, Y. Maman, J. Glanville, I. Alter et al., Estimate of within population incremental selection through branch imbalance in lineage trees, Nucleic Acids Research, vol.22, issue.5, pp.46-46, 1198.
DOI : 10.1111/j.0014-3820.2002.tb01440.x
URL : https://academic.oup.com/nar/article-pdf/44/5/e46/17437570/gkv1198.pdf

T. Lebien and T. Tedder, B lymphocytes: how they develop and function, Blood, vol.112, issue.5, pp.1570-80, 2008.
DOI : 10.1182/blood-2008-02-078071

, Available from: https://www.imgt.org/IMGTrepertoire/2D3Dstruct

V. Martin, Y. Wu, C. Townsend, G. Lu, O. Hare et al., Transitional B cells in early human B cell development?time to revisit the paradigm? Front Immunol, 2016.

M. Macarthur and J. Thornton, Influence of proline residues on protein conformation, Journal of Molecular Biology, vol.218, issue.2, pp.397-412, 1991.
DOI : 10.1016/0022-2836(91)90721-H

S. Boyd, E. Marshall, J. Merker, J. Maniar, L. Zhang et al., Measurement and clinical monitoring of human lymphocyte clonality by mas sively parallel VDJ pyrosequencing, Sci Transl Med, 2009.

M. Levine, A. Haberman, D. Sant-'angelo, L. Hannum, M. Cancro et al., A B-cell receptor-specific selection step governs immature to mature B cell differentiation, Proceedings of the National Academy of Sciences, vol.276, issue.5321, pp.2743-2751, 2000.
DOI : 10.1126/science.276.5321.2057

B. Briney, J. Willis, B. Mckinney, J. Crowe, and . Jr, Highthroughput antibody sequ encing reveals genetic evidence of global regulation of the naive and memory repertoires that extends across individuals, Genes Immun, 2012.

D. Dunnwalters and A. Ademokun, B cell repertoire and ageing, Current Opinion in Immunology, vol.22, issue.4, pp.514-534, 2010.
DOI : 10.1016/j.coi.2010.04.009

C. Wang, Y. Liu, L. Xu, K. Jackson, K. Roskin et al., Effects of Aging, Cytomegalovirus Infection, and EBV Infection on Human B Cell Repertoires, The Journal of Immunology, vol.192, issue.2, pp.603-614, 2014.
DOI : 10.4049/jimmunol.1301384

S. Boyd, B. Gaëta, K. Jackson, A. Fire, E. Marshall et al., Individual Variation in the Germline Ig Gene Repertoire Inferred from Variable Region Gene Rearrangements, The Journal of Immunology, vol.184, issue.12, pp.6986-92, 2010.
DOI : 10.4049/jimmunol.1000445