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Article Dans Une Revue Brain - A Journal of Neurology Année : 2018

Two critical brain networks for generation and combination of remote associations

Résumé

Recent functional imaging findings in humans indicate that creativity relies on spontaneous and controlled processes, possibly supported by the default mode and the fronto-parietal control networks, respectively. Here, we examined the ability to generate 10 and combine remote semantic associations, in relation to creative abilities, in patients with focal frontal lesions. Voxel-based lesion-deficit mapping, disconnection-deficit mapping and network-based lesion-deficit approaches revealed critical prefrontal nodes and connections for distinct mechanisms related to creative cognition. Damage to the right medial prefrontal region, or its potential disrupting effect on the default mode network, affected the ability to generate remote ideas, likely by altering the organization of semantic associations. Damage to the left rostrolateral prefrontal region and its connections, or its potential disrupting effect on the 15 left fronto-parietal control network, spared the ability to generate remote ideas but impaired the ability to appropriately combine remote ideas. Hence, the current findings suggest that damage to specific nodes within the default mode and fronto-parietal control networks led to a critical loss of verbal creative abilities by altering distinct cognitive mechanisms.
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Dates et versions

hal-01897580 , version 1 (17-10-2018)

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David Bendetowicz, Marika Urbanski, Béatrice Garcin, Chris Foulon, Richard Levy, et al.. Two critical brain networks for generation and combination of remote associations. Brain - A Journal of Neurology , 2018, 141 (1), pp.217-233. ⟨10.1093/brain/awx294⟩. ⟨hal-01897580⟩
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