Neural correlates of episodic memory in the Memento cohort

Stéphane Epelbaum 1, 2, 3, 4, 5, 6 Vincent Bouteloup 7, 8, 9 Jean Mangin 10, 11 Valentina La Corte 12, 13, 14, 15 Raffaela Migliaccio 1, 2, 3, 4, 5 Hugo Bertin 16, 10, 5, 4 Marie O. Habert 16, 10, 5, 4 Clara Fischer 10, 11 Chabha Azouani 10 Ludovic Fillon 10 Marie Chupin 10 Bruno Vellas 17, 18 Florence Pasquier 19 Jean Dartigues 8, 7, 9 Frédéric Blanc 20 Audrey Gabelle 21, 22, 23, 24 Mathieu Ceccaldi 25, 26, 27 Pierre Krolak-Salmon 28, 29 Jacques Hugon 30, 31 Olivier Hanon 32, 14 Olivier Rouaud 33 Renaud David 34 Geneviève Chêne 8, 7, 9 Bruno Dubois 3, 1, 2, 35, 5 Carole Dufouil 8, 7, 9
6 ARAMIS - Algorithms, models and methods for images and signals of the human brain
SU - Sorbonne Université, Inria de Paris, ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
Abstract : Introduction The free and cued selective reminding test is used to identify memory deficits in mild cognitive impairment and demented patients. It allows assessing three processes: encoding, storage, and recollection of verbal episodic memory. Methods We investigated the neural correlates of these three memory processes in a large cohort study. The Memento cohort enrolled 2323 outpatients presenting either with subjective cognitive decline or mild cognitive impairment who underwent cognitive, structural MRI and, for a subset, fluorodeoxyglucose–positron emission tomography evaluations. Results Encoding was associated with a network including parietal and temporal cortices; storage was mainly associated with entorhinal and parahippocampal regions, bilaterally; retrieval was associated with a widespread network encompassing frontal regions. Discussion The neural correlates of episodic memory processes can be assessed in large and standardized cohorts of patients at risk for Alzheimer's disease. Their relation to pathophysiological markers of Alzheimer's disease remains to be studied.
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Stéphane Epelbaum, Vincent Bouteloup, Jean Mangin, Valentina La Corte, Raffaela Migliaccio, et al.. Neural correlates of episodic memory in the Memento cohort. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2018, 4, pp.224-233. ⟨10.1016/j.trci.2018.03.010⟩. ⟨hal-01958834⟩

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