S. Norton, F. E. Matthews, D. E. Barnes, K. Yaffe, and C. Brayne, Potential for 358 primary prevention of Alzheimer's disease: an analysis of population359 based data, Lancet Neurol, vol.13, pp.788-794, 2014.

R. A. Whitmer, S. Sidney, J. Selby, S. C. Johnston, and K. Yaffe, Midlife 361 cardiovascular risk factors and risk of dementia in late life, Neurology, vol.362, pp.277-281, 2005.

A. Marengoni, D. Rizzuto, H. Wang, B. Winblad, and L. Fratiglioni, Patterns of 364 chronic multimorbidity in the elderly population, J. Am. Geriatr. Soc, vol.365, pp.225-230, 2009.

M. Vassilaki, J. A. Aakre, R. H. Cha, W. K. Kremers, S. Sauver et al., 367 et al. Multimorbidity and Risk of Mild Cognitive Impairment, J. Am. Geriatr

, Soc, vol.63, pp.1783-1790, 2015.

S. M. Smith, W. E. O'dowd, T. Fortin, and M. , Interventions for improving 370 outcomes in patients with multimorbidity in primary care and community 371 settings, Cochrane Database Syst. Rev, vol.3, p.6560, 2016.

M. Fotuhi, D. Do, and C. Jack, Modifiable factors that alter the size of the 373 hippocampus with ageing, Nat. Rev. Neurol, vol.8, pp.189-202, 2012.

, Age, mean (SD)