D. Golshayan and M. Pascual, Tolerance-inducing immunosuppressive strategies in clinical transplantation: an overview, Drugs, vol.68, pp.2113-2143, 2008.
DOI : 10.2165/00003495-200868150-00004

S. Hariharan, Improved graft survival after renal transplantation in the United States, N. Engl. J. Med, vol.342, pp.605-617, 1988.

M. Pascual, T. Theruvath, T. Kawai, N. Tolkoff-rubin, and A. B. Cosimi, Strategies to improve longterm outcomes after renal transplantation, N. Engl. J. Med, vol.346, pp.580-90, 2002.
DOI : 10.1056/nejmra011295

J. A. Fishman and R. H. Rubin, Infection in organtransplant recipients, N. Engl. J. Med, vol.338, pp.1741-51, 1998.

J. Dantal, Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens, Lancet, vol.351, pp.623-631, 1998.

M. Hojo, Cyclosporine induces cancer progression by a cell-autonomous mechanism, Nature, vol.397, pp.530-534, 1999.
DOI : 10.1097/00005392-199909010-00110

C. A. Roberts, D. L. Stern, and S. J. Radio, Asymmetric cardiac hypertrophy at autopsy in patients who received FK506 (tacrolimus) or cyclosporine A after liver transplant, Transplantation, vol.74, pp.817-838, 2002.

B. J. Nankivell, Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology, Transplantation, vol.78, pp.557-65, 2004.
DOI : 10.1097/01.tp.0000128636.70499.6e

Y. Fuchimoto, Mixed chimerism and tolerance without whole body irradiation in a large animal model, J. Clin. Invest, vol.105, pp.1779-89, 2000.

T. Kawai, CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates, Am. J. Transplant, vol.4, pp.1391-1399, 2004.

T. Wekerle, Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment, Nat. Med, vol.6, pp.464-473, 2000.

K. M. Zoller, S. I. Cho, J. J. Cohen, and J. T. Harrington, Cessation of immunosuppressive therapy after successful transplantation: a national survey, Kidney Int, vol.18, pp.110-114, 1980.

S. Louis, Contrasting CD25hiCD4+ T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance, Transplantation, vol.81, pp.398-407, 2006.
DOI : 10.1097/01.tp.0000203166.44968.86

J. A. Pons, FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal, Transplantation, vol.86, pp.1370-1378, 2008.

S. Brouard, Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance, Proc. Natl. Acad. Sci. U. S. A, vol.104, pp.15448-53, 2007.

M. Martinez-llordella, Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients, J. Clin. Invest, vol.118, pp.2845-57, 2008.

C. Braudeau, Variation in numbers of CD4(+)CD25(high)FOXP3(+) T cells with normal immuno-regulatory properties in long-term graft outcome, Transpl. Int, vol.20, pp.845-55, 2007.

P. M. Moraes-vieira, Differential monocyte STAT6 activation and CD4(+)CD25(+)Foxp3(+) T cells in kidney operational tolerance transplanted individuals, Hum. Immunol, vol.71, pp.442-50, 2010.

A. Pallier, Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype, Kidney Int, vol.78, pp.503-516, 2010.

K. A. Newell, Identification of a B cell signature associated with renal transplant tolerance in humans, J. Clin. Invest, vol.120, pp.1836-1883, 2010.

S. L. Swain and R. W. Dutton, Consequences of the direct interaction of helper T cells with B cells presenting antigen, Immunol. Rev, vol.99, pp.263-80, 1987.

S. K. Pierce, Antigen-presenting function of B lymphocytes, Immunol. Rev, vol.106, pp.149-80, 1988.

A. Mizoguchi and A. K. Bhan, A case for regulatory B cells, J. Immunol, vol.176, pp.705-715, 2006.

D. P. Harris, Reciprocal regulation of polarized cytokine production by effector B and T cells, Nat. Immunol, vol.1, pp.475-82, 2000.

D. P. Harris, S. Goodrich, A. J. Gerth, S. L. Peng, and F. E. Lund, Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor, J. Immunol, vol.174, pp.6781-90, 2005.

S. Fillatreau, C. H. Sweenie, M. J. Mcgeachy, D. Gray, and S. M. Anderton, B cells regulate autoimmunity by provision of IL-10, Nat. Immunol, vol.3, pp.944-50, 2002.

C. Mauri, D. Gray, N. Mushtaq, and M. Londei, Prevention of arthritis by interleukin 10producing B cells, J. Exp. Med, vol.197, pp.489-501, 2003.

A. Mizoguchi, E. Mizoguchi, H. Takedatsu, R. S. Blumberg, and A. K. Bhan, Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation, Immunity, vol.16, pp.219-249, 2002.

K. Yanaba, A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses, Immunity, vol.28, pp.639-50, 2008.

P. A. Blair, Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2like B cells and for the suppression of lupus in MRL/lpr mice, J. Immunol, vol.182, pp.3492-502, 2009.

Y. Iwata, Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells, Blood, vol.117, pp.530-571, 2010.

P. A. Blair, CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients, Immunity, vol.32, pp.129-169, 2010.

E. M. Shevach, From vanilla to 28 flavors: multiple varieties of T regulatory cells, Immunity, vol.25, pp.195-201, 2006.

L. C. Racusen, P. F. Halloran, and K. Solez, Banff 2003 meeting report: new diagnostic insights and standards, Am. J. Transplant, vol.4, pp.1562-1568, 2004.

K. Solez, Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'), Am. J. Transplant, vol.7, pp.518-544, 2007.

D. W. Cockcroft and M. H. Gault, Prediction of creatinine clearance from serum creatinine, Nephron, vol.16, pp.31-41, 1976.
DOI : 10.1159/000180580

R. Carsetti, M. M. Rosado, and H. Wardmann, Peripheral development of B cells in mouse and man, Immunol. Rev, vol.197, pp.179-91, 2004.

G. P. Sims, Identification and characterization of circulating human transitional B cells, Blood, vol.105, pp.4390-4398, 2005.
DOI : 10.1182/blood-2004-11-4284

URL : http://www.bloodjournal.org/content/105/11/4390.full.pdf

A. Lim, Many human peripheral VH5-expressing IgM+ B cells display a unique heavy-chain rearrangement, Int. Immunol, vol.20, pp.105-121, 2008.
DOI : 10.1093/intimm/dxm125

URL : https://hal.archives-ouvertes.fr/pasteur-00319682

J. J. Van-dongen, Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936, Leukemia, vol.17, pp.2257-317, 2003.

A. Collette, P. A. Cazenave, S. Pied, and A. Six, New methods and software tools for high throughput CDR3 spectratyping: application to T lymphocyte repertoire modifications during experimental malaria, J. Immunol. Methods, vol.278, pp.105-121, 2003.
DOI : 10.1016/s0022-1759(03)00225-4

A. Collette and A. Six, ISEApeaks: an Excel platform for GeneScan and Immunoscope data retrieval, management and analysis, vol.18, pp.329-359, 2002.
DOI : 10.1093/bioinformatics/18.2.329

URL : https://academic.oup.com/bioinformatics/article-pdf/18/2/329/605934/180329.pdf

M. Cochet, Molecular detection and in vivo analysis of the specific T cell response to a protein antigen, Eur. J. Immunol, vol.22, pp.2639-2686, 1992.

S. Hori, A. Collette, J. Demengeot, and J. Stewart, A new statistical method for quantitative analyses: application to the precise quantification of T cell receptor repertoires, J. Immunol. Methods, vol.268, pp.159-70, 2002.

C. Pannetier, The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments, Proc. Natl. Acad. Sci. U. S. A, vol.90, pp.4319-4342, 1993.

C. J. Wu, Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism, Blood, vol.95, pp.352-361, 2000.

J. R. Wehner, B cells and plasma cells in coronaries of chronically rejected cardiac transplants, Transplantation, vol.89, pp.1141-1149, 2010.
DOI : 10.1097/tp.0b013e3181d3f271

O. M. Steinmetz, R. A. Stahl, and U. Panzer, Chemokines and B cells in renal inflammation and allograft rejection, Front. Biosci. (Schol. Ed.), vol.1, pp.13-22, 2009.
DOI : 10.2741/e2

O. M. Steinmetz, BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection, Kidney Int, vol.67, pp.1616-1637, 2005.
DOI : 10.1111/j.1523-1755.2005.00244.x

URL : https://doi.org/10.1111/j.1523-1755.2005.00244.x

L. D. Cornell, R. N. Smith, and R. B. Colvin, Kidney transplantation: mechanisms of rejection and acceptance, Annu. Rev. Pathol, vol.3, pp.189-220, 2008.
DOI : 10.1146/annurev.pathol.3.121806.151508

A. Mizoguchi, E. Mizoguchi, R. N. Smith, F. I. Preffer, and A. K. Bhan, Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice, J. Exp. Med, vol.186, pp.1749-56, 1997.

Y. Iwata, Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells, Blood, vol.117, pp.530-571, 2011.

P. M. Vieira, Differential monocyte STAT6 activation and CD4+CD25+Foxp3+ T cell in kidney operational tolerance transplanted individuals, Hum Immunol, vol.71, pp.442-50, 2010.

C. Braudeau, Variation in numbers of CD4+CD25highFOXP3+ T cells with normal immuno-regulatory properties in long-term graft outcome, Transpl. Int, vol.20, pp.845-55, 2007.

C. Braudeau, Contrasted blood and intragraft toll-like receptor 4 mRNA profiles in operational tolerance versus chronic rejection in kidney transplant recipients, Transplantation, vol.86, pp.130-136, 2008.