Novel insights into mesothelioma biology and implications for therapy, Nat. Rev. Cancer, vol.17, pp.475-488, 2017. ,
Molecular changes in mesothelioma with an impact on prognosis and treatment, Arch. Pathol. Lab. Med, vol.136, pp.277-293, 2012. ,
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations, Nat. Genet, vol.48, pp.407-416, 2016. ,
Immunohistochemistry and molecular diagnostics of pleural malignant mesothelioma, Arch. Pathol. Lab. Med, vol.136, pp.253-261, 2012. ,
DOI : 10.5858/arpa.2010-0604-ra
Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases, J. Toxicol. Environ. Health B Crit. Rev, vol.14, pp.179-245, 2011. ,
Molecular classification of malignant pleural mesothelioma: identification of a poor prognosis subgroup linked to the epithelial-to-mesenchymal transition, Clin. Cancer Res, vol.20, pp.1323-1334, 2014. ,
Co-occurring mutations of tumor suppressor genes, LATS2 and NF2, in malignant pleural mesothelioma, Clin. Cancer Res, vol.23, pp.3191-3202, 2017. ,
Integrative molecular characterization of malignant pleural mesothelioma, Cancer Discov, vol.8, pp.1548-1565, 2018. ,
Global gene expression profiling of pleural mesotheliomas: overexpression of aurora kinases and P16/CDKN2A deletion as prognostic factors and critical evaluation of microarray-based prognostic prediction, Cancer Res, vol.66, pp.2970-2979, 2006. ,
Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profiling, Am. J. Pathol, vol.166, pp.1827-1840, 2005. ,
Analysis-ready standardized TCGA data from Broad GDAC Firehose stddata__2015_06_01 run. Broad Institute of MIT and Harvard, 2015. ,
The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment, Oncotarget, vol.8, pp.98580-98597, 2017. ,
Axl inhibitors as novel cancer therapeutic agents, Life Sci, vol.198, pp.99-111, 2018. ,
DOI : 10.1016/j.lfs.2018.02.033
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers, Am. J. Pathol, vol.164, pp.689-699, 2004. ,
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation, Cancer Cell, vol.18, pp.553-567, 2010. ,
Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome, Cancer Res, vol.69, pp.227-234, 2009. ,
DOI : 10.1158/0008-5472.can-08-2586
URL : http://cancerres.aacrjournals.org/content/69/1/227.full.pdf
Targeting the epigenome in malignant pleural mesothelioma, Transl. Lung Cancer Res, vol.6, pp.350-365, 2017. ,
MiR-21 over-expression and programmed cell death 4 down-regulation features malignant pleural mesothelioma, Oncotarget, vol.9, pp.17300-17308, 2018. ,
The role of miR-21 in cancer, Drug. Dev. Res, vol.76, pp.270-277, 2015. ,
MicroRNA-148a suppresses epithelial-to-mesenchymal transition by targeting ROCK1 in non-small cell lung cancer cells, Mol. Cell. Biochem, vol.380, pp.277-282, 2013. ,
hsa-miR-29c* is linked to the prognosis of malignant pleural mesothelioma, Cancer Res, vol.70, pp.1916-1924, 2010. ,
miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis, Cell Death Dis, vol.8, p.2739, 2017. ,
DOI : 10.1038/cddis.2017.61
URL : https://www.nature.com/articles/cddis201761.pdf
Tumour-suppressive microRNA-24-1 inhibits cancer cell proliferation through targeting FOXM1 in bladder cancer, FEBS Lett, vol.588, pp.3170-3179, 2014. ,
DOI : 10.1016/j.juro.2014.02.846
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis, Nat. Cell Biol, vol.10, pp.202-210, 2008. ,
DOI : 10.1038/ncb1681
Genomics of drug sensitivity in cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells, Nucleic Acids Res, vol.41, pp.955-961, 2013. ,
Stem cell factor-based identification and functional properties of in vitro-selected subpopulations of malignant mesothelioma cells, Stem Cell Rep, vol.8, pp.1005-1017, 2017. ,
Novel therapies for malignant pleural mesothelioma, Lancet Oncol, vol.19, pp.161-172, 2018. ,
DOI : 10.1016/s1470-2045(18)30100-1
Immune and stromal classification of colorectal cancer is associated with molecular subtypes and relevant for precision immunotherapy, Clin. Cancer Res, vol.22, pp.4057-4066, 2016. ,
IDO1 in cancer: a Gemini of immune checkpoints, Cell. Mol. Immunol, vol.15, pp.447-457, 2018. ,
VISTA is a novel broad-spectrum negative checkpoint regulator for cancer immunotherapy, Cancer Immunol. Res, vol.2, pp.510-517, 2014. ,
DOI : 10.1158/2326-6066.cir-14-0072
URL : http://cancerimmunolres.aacrjournals.org/content/canimm/2/6/510.full.pdf
Cisplatin and pemetrexed activate AXL and AXL inhibitor BGB324 enhances mesothelioma cell death from chemotherapy, Front. Pharmacol, vol.8, p.970, 2017. ,
DOI : 10.3389/fphar.2017.00970
URL : https://www.frontiersin.org/articles/10.3389/fphar.2017.00970/pdf
Mesothelial progenitor cells and their potential in tissue engineering, Int. J. Biochem. Cell. Biol, vol.36, pp.621-642, 2004. ,
DOI : 10.1016/j.biocel.2003.11.002
Cell adhesion and matrix stiffness: coordinating cancer cell invasion and metastasis, Front. Oncol, vol.8, p.145, 2018. ,
DOI : 10.3389/fonc.2018.00145
URL : https://www.frontiersin.org/articles/10.3389/fonc.2018.00145/pdf
Targeting YAP in malignant pleural mesothelioma, J. Cell. Mol. Med, vol.21, pp.2663-2676, 2017. ,
Novel insights into the roles of Rho kinase in cancer, Arch. Immunol. Ther. Exp, vol.64, pp.259-278, 2016. ,
MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells, Mol. Cancer Ther, vol.11, pp.174-182, 2012. ,
DOI : 10.1158/1535-7163.mct-11-0529
URL : http://mct.aacrjournals.org/content/11/1/174.full.pdf
Targeting WEE1 kinase in cancer, Trends Pharmacol. Sci, vol.37, pp.872-881, 2016. ,
Heterogeneity in immune cell content in malignant pleural mesothelioma, Int. J. Mol. Sci, vol.19, p.1041, 2018. ,
Mesothelin immunotherapy for cancer: ready for prime time?, J. Clin. Oncol, vol.34, pp.4171-4179, 2016. ,
Role of the complement system in NK cell-mediated antitumor T-cell responses, Oncoimmunology, vol.3, p.27897, 2014. ,
Nivolumab or nivolumab plus ipilimumab in patients with relapsed malignant pleural mesothelioma (IFCT-1501 MAPS2): a multicentre, open-label, randomised, non-comparative, phase 2 trial, Lancet Oncol, vol.20, pp.239-253, 2019. ,
ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels, Br. J. Cancer, vol.112, pp.1059-1066, 2015. ,
Predicting tumor purity from methylation microarray data, Bioinformatics, vol.31, pp.3401-3405, 2015. ,
DOI : 10.1093/bioinformatics/btv370
URL : https://academic.oup.com/bioinformatics/article-pdf/31/21/3401/17122211/btv370.pdf
InfiniumPurify: an R package for estimating and accounting for tumor purity in cancer methylation research, Genes Dis, vol.5, pp.43-45, 2018. ,
CpG island methylator phenotype in colorectal cancer, Proc. Natl Acad. Sci. USA, vol.96, pp.8681-8686, 1999. ,
High-throughput multiplex sequencing of miRNA, Curr. Protoc. Hum. Genet, vol.73, 2012. ,
DOI : 10.1002/0471142905.hg1112s73
URL : http://europepmc.org/articles/pmc3673877?pdf=render
sRNAbench: profiling of small RNAs and its sequence variants in single or multi-species high-throughput experiments, Methods, vol.1, pp.21-31, 2014. ,
Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments, BMC Bioinform, vol.11, p.94, 2010. ,
miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database, Nucleic Acids Res, vol.44, pp.239-247, 2016. ,
DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions, Nucleic Acids Res, vol.43, pp.153-159, 2015. ,
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data, Cancer Discov, vol.2, pp.401-404, 2012. ,
DOI : 10.1158/2159-8290.cd-12-0095
URL : http://cancerdiscovery.aacrjournals.org/content/2/5/401.full.pdf
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal, Sci. Signal, vol.6, p.1, 2013. ,
Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value, PLoS Med, vol.10, p.1001453, 2013. ,
The consensus molecular subtypes of colorectal cancer, Nat. Med, vol.21, pp.1350-1356, 2015. ,
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update, Nucleic Acids Res, vol.44, pp.90-97, 2016. ,
ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking, Bioinformatics, vol.26, pp.1572-1573, 2010. ,
In vitro effects of recombinant human interferon gamma on human mesothelioma cell lines, Int. J. Cancer, vol.55, pp.515-520, 1993. ,
Use of the 22C3 anti-PD-L1 antibody to determine PD-L1 expression in multiple automated immunohistochemistry platforms, PLoS One, vol.12, p.183023, 2017. ,
, 2014-2019) and the Société Française de Chirurgie-Thoracique et Cardiovasculaire (SFCTV). LQ was supported by grants from Cancéropôle Région Île
, Coup d'Elan de la Fondation Bettencourt-Shueller, the SIRIC CAR-PEM, the Institut thématique multi-organismes (ITMO) Cancer (Plan Cancer 2014-2019) and Cancéropôle Île-de-France. The Institut Curie RPPA platform is supported by Cancéropôle Ile-de-France and we thank Bérengère Ouine et Aurélie Cartier for acquisition of RPPA data. English was improved by, The Inserm research unit is supported by the Labex OncoImmunology (investissement d'avenir)