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, A randomized controlled trial which gave promising results suggesting the possibility of implementing statins in treatment of SPG5 with the potential role of 27-OH cholesterol as a biomarker responding in the plasma but not in the CSF

C. Marelli, F. Lamari, and D. Rainteau, This is a clinical trial that analyzed atorvastatin, chenodeoxycholic acid and resveratrol for treatment of SPG5 patients. The study suggested a combination of atorvastatin and chenodeoxycholic acid for treatment of SPG5 patients, Brain, vol.141, issue.1, p.20, 2018.

*. Boutry, M. Branchu, J. Lustrement, and C. , Inhibition of lysosome membrane recycling causes accumulation of gangliosides that contribute to neurodegeneration, Cell Rep, vol.23, pp.3813-3826, 2018.

, A study showing the first biomarker of therapeutic interest in spastic paraplegia 11

*. Bellofatto, M. , D. Michele, G. Iovino, and A. , A systematic review that analyzed 27 articles discussing the different hereditary spastic paraplegia treatment options: pharmacological, surgical and physiotherapy, Front Neurol, vol.22, 2019.

*. Garcia-cazorla, À. Mochel, F. Lamari, and F. , The clinical spectrum of inherited diseases involved in the synthesis and remodeling of complex lipids. A tentative overview, A comprehensive review demonstrating the spectrum of neurological disorders in which lipid metabolism plays a role, vol.38, pp.19-40, 2015.
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A. Vanderver, M. Prust, and D. Tonduti, Thirteen experts from multiple institutes created a scheme for objective case definition and classification of white matter disorders using a modified Delphi approach, Mol Genet Metab, vol.114, issue.4, pp.494-500, 2015.

C. M. Durand, L. Dhers, and C. Tesson, CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56, Hum Mut, vol.39, pp.140-151, 2018.
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M. Martignoni, E. Riano, and E. I. Rugarli, The role of ZFYVE27/protrudin in hereditary spastic paraplegia, Am J Hum Genet, vol.83, issue.1, pp.127-128, 2008.