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A. Duval and A. Collura, Aurélien de Reyniès, Anastasia Goloudina, Laetitia Marisa, and Vincent Jonchere were responsible for the study conceptualization

A. Guilloux, A. De-reyniès, L. Marisa, V. Jonchere, and A. Duval, Alain Virouleau, and Ada Collura were responsible for the methodology

A. Collura, M. Greene, O. Buhard, R. Bertrand, M. Svrcek et al.,

A. Duval, V. Jonchere, L. Marisa, and A. Collura, Agathe Guilloux, and Aurélien de Reyniès wrote the original draft; and Alex Duval was responsible for supervision. Conflicts of interest The authors disclose no conflicts. Funding This work was supported by grants Institut National Du Cancer, Programme de Recherche Translationnelle en Cancérologie "MicroSplicoter", sites de recherche intégrée sur le cancer (SIRIC) and Heterogeneity of Tumors & Ecosystem (HTECoLi) from the Institut National du Cancer (A.D.), the Fondation Association pour la Recherche sur le Cancer (A.C.), and the Canceropole Ile de France (A.C.). This work is part of the Cartes d'Identité des Tumeurs research program