Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease

Pauline Olivieri; Julien Lagarde; Stéphane Lehéricy; Romain Valabrègue; Adeline Michel; Pierre Mace; Fabien Caillé; Philippe Gervais; Michel Bottlaender; Marie Sarazin

doi:10.1002/acn3.50818

Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease

Pauline Olivieri ^{1, 2, 3, 4} Julien Lagarde ^{1, 2, 3, 4} Stéphane Lehéricy ^{5, 6} Romain Valabrègue ^{1, 4} Adeline Michel ^{1, 4} Pierre Mace ^{1, 4} Fabien Caillé ^{2, 3} Philippe Gervais ^{2, 3} Michel Bottlaender ^{2, 3, 7} Marie Sarazin ^{1, 4, 2, 3}

1 USPC - Université Sorbonne Paris Cité

2 IMIV - U1023 - ERL9218 - Imagerie Moléculaire in Vivo

3 SHFJ - Service Hospitalier Frédéric Joliot

4 Centre Hospitalier Sainte Anne [Paris]

5 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute

6 CENIR - Centre de Neuro-Imagerie de Recherche

7 UNIACT - Unité de recherche en NeuroImagerie Applicative Clinique et Translationnelle

Abstract : Neuropathological studies showed early locus coeruleus (LC) neuronal loss associated with tauopathy in Alzheimer's Disease (AD). We used the LC signal intensity (LC-I) on 3T MRI to assess the LC integrity in AD (n = 37) and controls (n = 17). The LC-I was decreased in AD regardless of typical (amnesic) and atypical presentation (logopenic aphasia/visuo-spatial deficit), from the prodromal stage, and independently of the amyloid load measured by PiB-PET. The LC-I was correlated with memory performance of typical AD. This supports the pathophysiological model in which the LC plays a critical role in AD and may thus be a potential therapeutic target.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Neurons and Cognition [q-bio.NC] / Neurobiology

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https://hal.sorbonne-universite.fr/hal-02279493
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Submitted on : Thursday, September 5, 2019 - 12:24:44 PM
Last modification on : Thursday, January 9, 2020 - 10:48:02 AM

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Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease

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Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease

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