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Journal articles
Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease
Abstract : Neuropathological studies showed early locus coeruleus (LC) neuronal loss associated with tauopathy in Alzheimer's Disease (AD). We used the LC signal intensity (LC-I) on 3T MRI to assess the LC integrity in AD (n = 37) and controls (n = 17). The LC-I was decreased in AD regardless of typical (amnesic) and atypical presentation (logopenic aphasia/visuo-spatial deficit), from the prodromal stage, and independently of the amyloid load measured by PiB-PET. The LC-I was correlated with memory performance of typical AD. This supports the pathophysiological model in which the LC plays a critical role in AD and may thus be a potential therapeutic target.
Cited literature [28 references]
https://hal.sorbonne-universite.fr/hal-02279493
Contributor : Hal Sorbonne Université Gestionnaire <>
Submitted on : Thursday, September 5, 2019 - 12:24:44 PM
Last modification on : Thursday, September 2, 2021 - 9:08:50 AM
Long-term archiving on: : Thursday, February 6, 2020 - 5:00:48 AM
Contributor : Hal Sorbonne Université Gestionnaire <>
Submitted on : Thursday, September 5, 2019 - 12:24:44 PM
Last modification on : Thursday, September 2, 2021 - 9:08:50 AM
Long-term archiving on: : Thursday, February 6, 2020 - 5:00:48 AM
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Olivieri_et_al-2019-Annals_of_...
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