T. Arendt, M. K. Br?-uckner, and M. Morawski, Early neurone loss in Alzheimer's disease: cortical or subcortical?, Acta Neuropathol Commun, vol.3, p.10, 2015.

A. Grudzien, P. Shaw, and S. Weintraub, Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease, Neurobiol Aging, vol.28, pp.327-335, 2007.

C. Zarow, S. A. Lyness, J. A. Mortimer, and H. C. Chui, Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases, Arch Neurol, vol.60, pp.337-341, 2003.

S. C. Kelly, B. He, and S. E. Perez, Locus coeruleus cellular and molecular pathology during the progression of Alzheimer's disease, Acta Neuropathol Commun, vol.5, p.8, 2017.

G. Simi-c, M. B. Leko, and S. Wray, Monoaminergic neuropathology in Alzheimer's disease, Prog Neurogibol, vol.151, pp.101-138, 2017.

H. Braak, D. R. Thal, E. Ghebremedhin, D. Tredici, and K. , Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years, J Neuropathol Exp Neurol, vol.70, pp.960-969, 2011.

H. Braak, D. Tredici, and K. , Alzheimer's pathogenesis: is there neuron-to-neuron propagation?, Acta Neuropathol, vol.121, pp.589-595, 2011.

Y. S. Eisele and C. Duyckaerts, Propagation of Aß pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies, Acta Neuropathol, vol.131, pp.5-25, 2016.

P. Theofilas, A. J. Ehrenberg, and S. Dunlop, Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery, Alzheimers Dement, vol.13, pp.236-246, 2017.

D. Weinshenker, Long road to ruin: noradrenergic dysfunction in neurodegenerative disease, Trends Neurosci, vol.41, pp.211-223, 2018.

M. T. Heneka, F. Nadrigny, and T. Regen, Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine, Proc Natl Acad Sci, vol.107, pp.6058-6063, 2010.

T. Hammerschmidt, M. P. Kummer, and D. Terwel, Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice, Biol Psychiatry, vol.73, pp.454-463, 2013.

S. J. Sara, The locus coeruleus and noradrenergic modulation of cognition, Nat Rev Neurosci, vol.10, pp.211-223, 2009.

N. I. Keren, S. Taheri, and E. M. Vazey, Histologic validation of locus coeruleus MRI contrast in post-mortem tissue, NeuroImage, vol.113, pp.235-245, 2015.

N. I. Keren, C. T. Lozar, and K. C. Harris, In vivo mapping of the human locus coeruleus, NeuroImage, vol.47, pp.1261-1267, 2009.

D. Garc-ia-lorenzo, L. Santos, C. Ewenczyk, and C. , The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson's disease, Brain, vol.136, pp.2120-2129, 2013.

L. C. De-souza, F. Corlier, and M. Habert, Similar amyloid-b burden in posterior cortical atrophy and Alzheimer's disease, Brain, vol.134, pp.2036-2043, 2011.

B. Fischl, D. H. Salat, and E. Busa, Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain, Neuron, vol.33, pp.341-355, 2002.

H. Braak, D. Tredici, and K. , Where, when, and in what form does sporadic Alzheimer's disease begin?, Curr Opin Neurol, vol.25, pp.708-714, 2012.

K. Y. Liu, J. Acosta-cabronero, and A. Cardenas-blanco, In vivo visualization of age-related differences in the locus coeruleus, Neurobiol Aging, vol.74, pp.101-111, 2019.

E. Shibata, M. Sasaki, and K. Tohyama, Age-related changes in locus ceruleus on neuromelanin magnetic resonance imaging at 3 Tesla, Magn Reson Med Sci, vol.5, pp.197-200, 2006.

T. G. Ohm, C. Busch, and J. Bohl, Unbiased estimation of neuronal numbers in the human nucleus coeruleus during aging, Neurobiol Aging, vol.18, pp.393-399, 1997.

J. Takahashi, T. Shibata, and M. Sasaki, Detection of changes in the locus coeruleus in patients with mild cognitive impairment and Alzheimer's disease: highresolution fast spin-echo T1-weighted imaging, Geriatr Gerontol Int, vol.15, pp.334-340, 2015.

M. Dordevic, A. M?-uller-fotti, and P. M?-uller, Optimal cutoff value for locus coeruleus-to-pons intensity ratio as clinical biomarker for Alzheimer's disease: a pilot study, J Alzheimers Dis Rep, vol.1, pp.159-167, 2017.

F. Miyoshi, T. Ogawa, and S. I. Kitao, Evaluation of Parkinson disease and Alzheimer disease with the use of neuromelanin MR imaging and (123)Imetaiodobenzylguanidine scintigraphy, AJNR Am J Neuroradiol, vol.34, pp.2113-2118, 2013.

A. Satoh and K. M. Iijima, Roles of tau pathology in the locus coeruleus (LC) in age-associated pathophysiology and Alzheimer's disease pathogenesis: potential strategies to protect the LC against aging, Brain Res, vol.1702, pp.17-28, 2019.

M. Iba, J. D. Mcbride, and J. L. Guo, Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections, Acta Neuropathol, vol.130, pp.349-362, 2015.

, The Authors. Annals of Clinical and Translational Neurology, 2019.