Skip to Main content Skip to Navigation
Journal articles

Computing three-dimensional densities from force densities improves statistical efficiency

Abstract : The extraction of inhomogeneous 3-dimensional densities around tagged solutes from molecular simulations is known to have a very high computational cost because this is traditionally performed by collecting histograms, with each discrete voxel in three-dimensional space needing to be visited significantly. This paper presents an extension of a previous methodology for the extraction of 3D solvent number densities with a reduced variance principle [Borgis et al., Mol. Phys. 2013 , 111, 3486-3492] to other 3D densities such as charge and polarization densities. The approach is also generalized to cover molecular solvents with structures described using rigid geometrical constraints, which include in particular popular water models such as SPC/E and TIPnP class of models. The noise reduction is illustrated for the microscopic hydration structure of a small molecule, in various simulation conditions, and for a protein. The method has large applicability to simulations of solvation in many fields, for example around biomolecules, nanoparticles, or within porous materials.
Complete list of metadata

Cited literature [39 references]  Display  Hide  Download
Contributor : Gestionnaire Hal-Su <>
Submitted on : Thursday, September 12, 2019 - 2:53:11 PM
Last modification on : Monday, January 4, 2021 - 11:08:02 AM
Long-term archiving on: : Saturday, February 8, 2020 - 4:27:31 AM


Files produced by the author(s)



Samuel W. Coles, Daniel Borgis, Rodolphe Vuilleumier, Benjamin Rotenberg. Computing three-dimensional densities from force densities improves statistical efficiency. Journal of Chemical Physics, American Institute of Physics, 2019, 151 (6), pp.064124. ⟨10.1063/1.5111697⟩. ⟨hal-02285093⟩



Record views


Files downloads