Alzheimer's disease: the right drug, the right time, Science, vol.362, issue.6420, pp.1250-1251, 2018. ,
Associations of amyloid, tau, and neurodegeneration biomarker profiles with rates of memory decline among individuals without dementia, JAMA, vol.321, issue.23, pp.2316-2341, 2019. ,
Alzheimer disease": multiple meanings separated by a common name, Neurology, vol.92, issue.22, pp.1053-1062, 2019. ,
KEGG: kyoto encyclopedia of genes and genomes, Nucleic Acids Res, vol.28, issue.1, pp.27-30, 2000. ,
New approach for understanding genome variations in KEGG, Nucleic Acids Res, vol.47, issue.D1, pp.590-595, 2019. ,
The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies, Brain, vol.142, issue.4, pp.1134-1181, 2019. ,
Predicting progression to mild cognitive impairment, Ann Neurol, vol.85, issue.1, pp.155-60, 2019. ,
Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study, Lancet Neurol, vol.17, issue.3, pp.241-50, 2018. ,
Current state of Alzheimer's fluid biomarkers, Acta Neuropathol, vol.136, issue.6, pp.821-53, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01960281
Cognitive and neuroimaging features and brain beta-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study, Lancet Neurol, vol.17, issue.4, pp.335-381, 2018. ,
Evaluation of amyloid status in a cohort of elderly individuals with memory complaints: validation of the method of quantification and determination of positivity thresholds, Ann Nucl Med, vol.32, issue.2, pp.75-86, 2018. ,
Annotation of the human cerebrospinal fluid lipidome using high resolution mass spectrometry and a dedicated data processing workflow, Metabolomics, vol.12, p.91, 2016. ,
R: A language and environment for statistical computing, 2018. ,
ProteoWizard: open source software for rapid proteomics tools development, Bioinformatics, vol.24, issue.21, pp.2534-2540, 2008. ,
XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification, Anal Chem, vol.78, issue.3, pp.779-87, 2006. ,
XCMS online: a web-based platform to process untargeted metabolomic data, Anal Chem, vol.84, issue.11, pp.5035-5044, 2012. ,
Workflow4Metabolomics: a collaborative research infrastructure for computational metabolomics, Bioinformatics, vol.31, issue.9, pp.1493-1498, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01214152
Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry, Nat Protoc, vol.6, issue.7, pp.1060-83, 2011. ,
Annotation of the human serum metabolome by coupling three liquid chromatography methods to high-resolution mass spectrometry, J Chromatogr B Analyt Technol Biomed Life Sci, vol.966, pp.34-47, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01664192
HMDB 4.0: The human metabolome database for, Nucleic Acids Res, vol.46, issue.D1, pp.608-625, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01712873
KEGG: new perspectives on genomes, pathways, diseases and drugs, Nucleic Acids Res, vol.45, issue.D1, pp.353-61, 2017. ,
Methods for the integration of multiomics data: mathematical aspects, BMC Bioinformatics, vol.17, p.15, 2016. ,
More is better: recent Progress in multi-omics data integration methods, Front Genet, vol.8, p.84, 2017. ,
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome Biol, vol.15, issue.12, p.550, 2014. ,
Adjusting batch effects in microarray expression data using empirical Bayes methods, Biostatistics, vol.8, issue.1, pp.118-145, 2007. ,
Comparison of different statistical approaches for urinary peptide biomarker detection in the context of coronary artery disease, BMC Bioinforma, vol.17, issue.1, p.496, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-01409597
Gene ranking and biomarker discovery under correlation, Bioinformatics, vol.25, pp.2700-2707, 1920. ,
Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables, Sci Rep, vol.8, issue.1, p.5530, 2018. ,
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool, BMC Bioinforma, vol.14, p.128, 2013. ,
Regularized generalized canonical correlation analysis, Psychometrika, vol.76, issue.2, p.257, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00609220
Variable selection for generalized canonical correlation analysis, Biostatistics, vol.15, issue.3, pp.569-83, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01071432
A strategy for multimodal data integration: application to biomarkers identification in spinocerebellar ataxia, Brief Bioinform, vol.19, issue.6, pp.1356-69, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01630727
mixOmics: An R package for 'omics feature selection and multiple data integration, PLoS Comput Biol, vol.13, issue.11, p.1005752, 2017. ,
Computationally efficient confidence intervals for cross-validated area under the ROC curve estimates, Electronic J Statistics, vol.9, issue.1, pp.1583-607, 2015. ,
APOE genotype and early beta-amyloid accumulation in older adults without dementia, Neurology, vol.89, issue.10, pp.1028-1062, 2017. ,
Multimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load, Neurology, vol.88, issue.6, pp.569-76, 2017. ,
Alzheimer disease: a major gene with semi-dominant inheritance, Mol Psychiatry, vol.16, issue.9, pp.903-910, 2011. ,
beta-Amyloid burden in healthy aging: regional distribution and cognitive consequences, Neurology, vol.78, issue.6, pp.387-95, 2012. ,
A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology, Neurobiol Dis, vol.124, pp.454-68, 2019. ,
Integrative analysis of blood metabolomics and PET brain neuroimaging data for Parkinson's disease, Neurobiol Dis, vol.124, pp.555-62, 2019. ,
Utility of neuronal-derived exosomes to examine molecular mechanisms that affect motor function in patients with Parkinson disease: a secondary analysis of the exenatide-PD trial, JAMA Neurol, vol.76, issue.4, pp.420-429, 2019. ,
Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as biomarkers, Philos Trans R Soc Lond B Biol Sci, vol.369, 1652. ,
Novel nucleophiles enhance the human serum paraoxonase 1 (PON1)-mediated detoxication of organophosphates, Toxicol Sci, vol.143, issue.1, pp.46-53, 2015. ,
Dual-opposite multi-walled carbon nanotube modified carbon fiber microelectrode for microfluidic chip-capillary electrophoresis determination of methyl parathion metabolites in human urine, Electrophoresis, vol.39, issue.11, pp.1375-81, 2018. ,
Parkinson's disease and the environment, Front Neurol, vol.10, p.218, 2019. ,
Gene-environment interactions in Alzheimer's disease: a potential path to precision medicine, Pharmacol Ther, vol.199, pp.173-87, 2019. ,
Metabolome in progression to Alzheimer's disease, Transl Psychiatry, vol.1, p.57, 2011. ,
Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics, PLoS One, vol.8, issue.5, p.63644, 2013. ,
Plasma metabolite profiles of Alzheimer's disease and mild cognitive impairment, J Proteome Res, vol.13, issue.5, pp.2649-58, 2014. ,
Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment, Lipids, vol.35, issue.12, pp.1305-1317, 2000. ,
Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology, J Lipid Res, vol.53, issue.3, pp.567-76, 2012. ,
Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics, PLoS One, vol.6, issue.7, p.21643, 2011. ,
Metabolic network failures in Alzheimer's disease: a biochemical road map, Alzheimers Dement, vol.13, issue.9, pp.965-84, 2017. ,
Plasma phospholipids identify antecedent memory impairment in older adults, Nat Med, vol.20, issue.4, pp.415-423, 2014. ,
The diagnostic value of FDG and amyloid PET in Alzheimer's diseasea systematic review, Eur J Radiol, vol.94, pp.16-24, 2017. ,
Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: a randomized controlled trial, BBA Clin, vol.3, pp.123-128, 2015. ,
Mechanisms of action for the mediumchain triglyceride ketogenic diet in neurological and metabolic disorders, Lancet Neurol, vol.17, issue.1, pp.84-93, 2018. ,
Blood genome-wide transcriptional profiles reflect broad molecular impairments and strong blood-brain links in Alzheimer's disease, J Alzheimers Dis, vol.43, issue.1, pp.93-108, 2015. ,
Transcriptional analysis of blood lymphocytes and skin fibroblasts, keratinocytes, and endothelial cells as a potential biomarker for Alzheimer's disease, J Alzheimers Dis, vol.54, issue.4, pp.1373-83, 2016. ,
Common aging signature in the peripheral blood of vascular dementia and Alzheimer's disease, Mol Neurobiol, vol.53, issue.6, pp.3596-605, 2016. ,
A blood gene expression marker of early Alzheimer's disease, J Alzheimers Dis, vol.33, issue.3, pp.737-53, 2013. ,
Gene expression profile analysis of lymphocytes from Alzheimer's patients, Psychiatr Genet, vol.15, issue.1, pp.1-6, 2005. ,
A gene expression pattern in blood for the early detection of Alzheimer's disease, J Alzheimers Dis, vol.23, issue.1, pp.109-128, 2011. ,
Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities, Alzheimer Dis Assoc Disord, vol.28, issue.3, pp.226-259, 2014. ,
Altered blood gene expression of tumorrelated genes (PRKCB, BECN1, and CDKN2A) in Alzheimer's disease, Mol Neurobiol, vol.53, issue.9, pp.5902-5913, 2016. ,
Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease, J Alzheimers Dis, vol.34, issue.2, pp.399-405, 2013. ,
Validation of AclarusDx, a blood-based transcriptomic signature for the diagnosis of Alzheimer's disease, J Alzheimers Dis, vol.32, issue.1, pp.169-81, 2012. ,
Multivariate analyses of peripheral blood leukocyte transcripts distinguish Alzheimer's, Parkinson's, control, and those at risk for developing Alzheimer's, Neurobiol Aging, vol.58, pp.225-262, 2017. ,
Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer's disease, Neurobiol Dis, vol.43, issue.3, pp.698-705, 2011. ,
The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia: a meta-analysis, Int J Geriatr Psychiatry, vol.23, issue.11, pp.1191-202, 2008. ,
Prevalence and determinants of subjective cognitive decline in a representative Greek elderly population, Int J Geriatr Psychiatry, vol.34, issue.6, pp.846-54, 2019. ,
Risk of progression from subjective cognitive decline to mild cognitive impairment: the role of study setting, Alzheimers Dement, vol.14, issue.6, pp.734-776, 2018. ,
Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease, Brain, vol.141, issue.6, pp.1855-70, 2018. ,
Interactive associations of vascular risk and beta-amyloid burden with cognitive decline in clinically normal elderly individuals: findings from the Harvard Aging Brain Study, JAMA Neurol, vol.75, issue.9, pp.1124-1155, 2018. ,
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature, J Neuropathol Exp Neurol, vol.71, issue.5, pp.362-81, 2012. ,