Mechanisms underlying inflammation in neurodegeneration, Cell, vol.140, issue.6, pp.918-952, 2010. ,
Molecular imaging of microglia/macrophages in the brain, Glia, vol.61, issue.1, pp.10-23, 2013. ,
Peripheral type" benzodiazepine binding sites in rat adrenals: binding studies with [3H]PK 11195 and autoradiographic localization, Arch Int Pharmacodyn Ther, vol.266, issue.1, pp.38-49, 1983. ,
Imaging Microglial Activation with TSPO PET: Lighting Up Neurologic Diseases?, J Nucl Med, vol.57, issue.2, pp.165-173, 2016. ,
Challenges of quantification of TSPO in the human brain, Clin Transl Imaging, vol.2015, pp.1-14 ,
Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation, J Nucl Med, vol.50, issue.3, pp.468-76, 2009. ,
An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28, J Cereb Blood Flow Metab, vol.32, issue.1, pp.1-5, 2012. ,
Quantification of the specific translocator protein signal of 18F-PBR111 in healthy humans: a genetic polymorphism effect on in vivo binding, J Nucl Med, vol.54, issue.11, pp.1915-1938, 2013. ,
Quantitation of translocator protein binding in human brain with the novel radioligand [18F]-FEPPA and positron emission tomography, J Cereb Blood Flow Metab, vol.31, issue.8, pp.1807-1823, 2011. ,
Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, (18)F-PBR06, J Nucl Med, vol.50, issue.7, pp.1047-53, 2009. ,
In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients, Eur J Nucl Med Mol Imaging, vol.40, issue.6, pp.921-952, 2013. ,
Imaging microglial/macrophage activation in spinal cords of experimental autoimmune encephalomyelitis rats by positron emission tomography using the mitochondrial 18 kDa translocator protein radioligand, J Neurosci, vol.32, issue.1, pp.5728-5764, 2012. ,
DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats, PLoS One, vol.18, issue.2, 2013. ,
Quantification of [lsqb]18F[rsqb]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer/'s disease patients, J Cereb Blood Flow Metab, vol.35, issue.5, pp.766-72, 2015. ,
Optimized quantification of TSPO radioligand 18F-DPA-714 uptake in the brain of genotyped healthy volunteers, Journal of Nuclear Medicine, 2015. ,
The methodology of TSPO imaging with positron emission tomography, Biochem Soc Trans, vol.43, issue.4, pp.586-92, 2015. ,
Development of a tracer kinetic plasma input model for (R)-[11C]PK11195 brain studies, J Cereb Blood Flow Metab, vol.25, issue.7, pp.842-51, 2005. ,
Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study, Neuroimage, vol.24, issue.2, pp.591-596, 2005. ,
Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging, Brain, vol.139, pp.1252-64, 2016. ,
Evaluation of reference regions for (R)-[(11)C]PK11195 studies in Alzheimer's disease and mild cognitive impairment, J Cereb Blood Flow Metab, vol.27, issue.12, pp.1965-74, 2007. ,
Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein, J Nucl Med, vol.56, issue.5, pp.701-707, 2015. ,
Increased PK11195 PET binding in the cortex of patients with MS correlates with disability, Neurology, vol.79, issue.6, pp.523-553, 2012. ,
Acute HCV/HIV Coinfection Is Associated with Cognitive Dysfunction and Cerebral Metabolite Disturbance, but Not Increased Microglial Cell Activation, PLoS One, vol.7, issue.7, 2012. ,
Labelling of peripheral-type benzodiazepine binding sites in human brain with [3H]PK 11195: anatomical and subcellular distribution, Brain research bulletin, vol.18, issue.1, pp.49-61, 1987. ,
Microglial activation in Alzheimer's disease: an (R)-[(1)(1)C]PK11195 positron emission tomography study, Neurobiol Aging, vol.34, issue.1, pp.128-164, 2013. ,
Reference and Target Region Modeling of [11C]-(R)-PK11195 Brain Studies, Journal of Nuclear Medicine, vol.48, issue.1, pp.158-67, 2007. ,
Optimization of supervised cluster analysis for extracting reference tissue ,
, 11C[rsqb]PK11195 brain PET studies, J Cereb Blood Flow Metab, vol.32, issue.8, pp.1600-1608, 2012.
Reference region automatic extraction in dynamic [11C]PIB, J Cereb Blood Flow Metab, vol.33, issue.11, pp.1725-1756, 2013. ,
Automated reference region extraction and population-based input function for brain [lsqb]11C[rsqb]TMSX PET image analyses, J Cereb Blood Flow Metab, vol.35, issue.1, pp.157-65, 2015. ,
Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis, PLoS One, vol.7, issue.12, 2012. ,
, 18F]PBR111 and [18F]FEDAA1106-selective radioligands for imaging TSPO 18 kDa with PET: automated radiosynthesis on a TRACERLAb FX-FN synthesizer and quality controls, vol.70, pp.489-97, 2012.
An anatomically comprehensive atlas of the adult human brain transcriptome, Nature, vol.489, issue.7416, pp.391-400, 2012. ,
A Strategy for Removing the Bias in the Graphical Analysis Method, J Cereb Blood Flow Metab, vol.21, issue.3, pp.307-327, 2001. ,
Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation, Nucl Med Biol, vol.39, issue.4, pp.570-578, 2012. ,
Intraclass correlations: uses in assessing rater reliability, Psychological bulletin, vol.86, issue.2, pp.420-428, 1979. ,
Test-retest reproducibility of [(11)C]PBR28 binding to TSPO in healthy control subjects, Eur J Nucl Med Mol Imaging, vol.43, issue.1, pp.173-83, 2016. ,
)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas, Eur J Nucl Med Mol Imaging, vol.42, issue.11, pp.1081-92, 2015. ,
)C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease, Neurobiol Aging, vol.44, issue.11, pp.53-61, 2016. ,
A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation, J Cereb Blood Flow Metab, vol.33, issue.1, pp.53-61, 2013. ,
Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV, J Neurovirol, vol.20, issue.3, pp.219-251, 2014. ,
Translocator protein (18 kDa) polymorphism (rs6971) explains in-vivo brain binding affinity of the PET radioligand [(18)F]-FEPPA, J Cereb Blood Flow Metab, vol.32, issue.6, pp.968-72, 2012. ,
Quantitative imaging of neuroinflammation in human white matter: a positron emission tomography study with translocator protein 18 kDa radioligand, FEPPA. Synapse, vol.68, issue.11, pp.536-583, 2014. ,
Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [C]PBR28 PET Brain Imaging Study, Am J Psychiatry, 2015. ,
Kinetic modeling using a two-tissue compartment model and an additional irreversible vascular component improves the quantification of [11C]PBR28 brain PET data, Journal of Nuclear Medicine, vol.55, p.2020, 2014. ,
Novel reference region model reveals increased microglial and reduced vascular binding of 11C-(R)-PK11195 in patients with Alzheimer's disease, J Nucl Med, vol.49, issue.8, pp.1249-56, 2008. ,
, SuperDPAHAB/MAB (middle) and the CRBGM (bottom) methods in HAB (n=7) and MAB (n=7) subjects. Error bars indicate the standard deviation. * Significant difference, BPND LOGAN estimates of each ROI using SuperDPAALL (top), vol.3