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Self‐Assembled Collagen Microparticles by Aerosol as a Versatile Platform for Injectable Anisotropic Materials

Abstract : innovative spray-processing approach enables fast and cheap production of anisotropic microparticles containing >90 wt% type I collagen. Their injection in a biological medium results in the formation of fibrils retaining innate molecular characteristics while forming ordered, organized structures at higher length scales. The encapsulation of temperature-sensitive stem-cell products demonstrates the versatility of the approach for tissue regeneration applications. 20 µm Encapsulation Injection Type I collagen molecules in soluƟon Gingival MSCs SecreƟon factors 20 µm SPRAY-DRYING
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Milena Lama, Francisco Fernandes, Alba Marcellan, Juliette Peltzer, Marina Trouillas, et al.. Self‐Assembled Collagen Microparticles by Aerosol as a Versatile Platform for Injectable Anisotropic Materials. Small, Wiley-VCH Verlag, In press, pp.1902224. ⟨10.1002/smll.201902224⟩. ⟨hal-02432930⟩

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