E. Aleyd, M. H. Heineke, and M. Van-egmond, The era of the immunoglobulin A Fc receptor Fc?RI; its function and potential as target in disease, Immunol. Rev, vol.268, pp.123-138, 2015.

N. P. Arbatsky, A. S. Shashkov, E. Literacka, G. Widmalm, W. Kaca et al., Structure of the O-specific polysaccharide of Proteus mirabilis O11, another Proteus Oantigen containing an amide of D-galacturonic acid with L-threonine, Carbohydr. Res, vol.323, pp.81-86, 2000.

C. Arpin, J. Déchanet, C. Van-kooten, P. Merville, G. Grouard et al., Generation of memory B cells and plasma cells in vitro, Science, vol.268, pp.720-722, 1995.

S. Balu, R. Reljic, M. J. Lewis, R. J. Pleass, R. Mcintosh et al.,

J. M. Challacombe, J. Woof, and . Ivanyi, A novel human IgA monoclonal antibody protects against tuberculosis, J. Immunol. Baltim. Md, vol.186, pp.3113-3119, 1950.

P. A. Bastos, J. P. Da-costa, and R. Vitorino, A glimpse into the modulation of posttranslational modifications of human-colonizing bacteria, J. Proteomics, vol.152, pp.254-275, 2017.

J. Benckert, N. Schmolka, C. Kreschel, M. J. Zoller, A. Sturm et al.,

. Wardemann, The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific, J. Clin. Invest, vol.121, pp.1946-1955, 2011.

M. A. Berkowska, G. J. Driessen, V. Bikos, C. Grosserichter-wagener, K. Stamatopoulos et al., Human memory B cells originate from three distinct germinal centerdependent and -independent maturation pathways, Blood, vol.118, pp.2150-2158, 2011.

M. A. Berkowska, J. Schickel, C. Grosserichter-wagener, D. De-ridder, Y. S. Ng et al., Circulating Human CD27-IgA+ Memory B Cells Recognize Bacteria with Polyreactive Igs, J. Immunol. Baltim. Md, vol.195, pp.1417-1426, 1950.

J. J. Bunker, S. A. Erickson, T. M. Flynn, C. Henry, J. C. Koval et al.,

P. C. Antonopoulos, A. Wilson, and . Bendelac, Natural polyreactive IgA antibodies coat the intestinal microbiota, Science, 2017.

J. J. Bunker, T. M. Flynn, J. C. Koval, D. G. Shaw, M. Meisel et al., Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A, Immunity, vol.43, pp.541-553, 2015.

C. A. Butler, P. D. Veith, M. F. Nieto, S. G. Dashper, and E. C. Reynolds, Lysine acetylation is a common post-translational modification of key metabolic pathway enzymes of the anaerobe Porphyromonas gingivalis, J. Proteomics, vol.128, pp.352-364, 2015.

O. V. Bystrova, G. V. Zatonskii, S. A. Borisova, N. A. Kocharova, A. S. Shashkov et al., Structure of an acidic O-specific polysaccharide of the bacterium Providencia alcalifaciens O7, Biochem. Biokhimiia, vol.65, pp.677-684, 2000.

M. Chiba, H. Ohta, H. Yagisawa, and O. Masamune, IgA1 & IgA2 distribution in the intestine, Gastroenterol. Jpn, vol.22, pp.18-23, 1987.

R. L. Coffman, D. A. Lebman, and B. Shrader, Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes, J. Exp. Med, vol.170, pp.1039-1044, 1989.

G. D'auria, F. Peris-bondia, M. D?unková, A. Mira, M. C. Collado et al.,

. Moya, Active and secreted IgA-coated bacterial fractions from the human gut reveal an under-represented microbiota core, Sci. Rep, vol.3, p.3515, 2013.

G. P. Donaldson, S. M. Lee, and S. K. Mazmanian, Gut biogeography of the bacterial microbiota, Nat. Rev. Microbiol, vol.14, pp.20-32, 2016.

J. Fadlallah, H. E. Kafsi, D. Sterlin, C. Juste, C. Parizot et al.,

P. P. De-barros, M. Malphettes, L. Galicier, D. Boutboul, A. Mathian et al.,

Z. Oksenhendler, J. Amoura, C. Doré, S. D. Fieschi, M. Ehrlich et al., Microbial ecology perturbation in human IgA deficiency, Sci. Transl. Med, vol.10, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01997107

S. J. Forbes, T. Bumpus, E. A. Mccarthy, B. Corthésy, and N. J. Mantis, Transient suppression of Shigella flexneri type 3 secretion by a protective O-antigen-specific monoclonal, IgA. mBio, vol.2, pp.42-53, 2011.

S. J. Forbes, M. Eschmann, and N. J. Mantis, Inhibition of Salmonella enterica serovar typhimurium motility and entry into epithelial cells by a protective antilipopolysaccharide monoclonal immunoglobulin A antibody, Infect. Immun, vol.76, pp.4137-4144, 2008.

C. Grangeasse, J. Stülke, and I. Mijakovic, Regulatory potential of post-translational modifications in bacteria, Front. Microbiol, vol.6, 2015.

A. Griesemer, K. Yamada, and M. Sykes, Xenotransplantation: immunological hurdles and progress toward tolerance, Immunol. Rev, vol.258, pp.241-258, 2014.

S. Von-gunten, D. F. Smith, R. D. Cummings, S. Riedel, S. Miescher et al.,

B. S. Hamilton and . Bochner, Intravenous immunoglobulin contains a broad repertoire of anticarbohydrate antibodies that is not restricted to the IgG2 subclass, J. Allergy Clin, 2009.

, Immunol, vol.123, pp.1268-1276

I. S. Hansen, W. Hoepel, S. A. Zaat, D. L. Baeten, and J. Den-dunnen, Serum IgA Immune Complexes Promote Proinflammatory Cytokine Production by Human Macrophages, Monocytes, and Kupffer Cells through Fc?RI-TLR Cross-Talk, J. Immunol. Baltim. Md, vol.199, pp.4124-4131, 1950.

G. R. Harriman, M. Bogue, P. Rogers, M. Finegold, S. Pacheco et al., Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes, J. Immunol. Baltim. Md, vol.162, pp.2521-2529, 1950.

B. He, W. Xu, P. A. Santini, A. D. Polydorides, A. Chiu et al.,

A. Villanacci, D. M. Plebani, M. Knowles, A. Rescigno, and . Cerutti, Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL, Immunity, vol.26, pp.812-826, 2007.

S. M. Hellwig, A. B. Van-spriel, J. F. Schellekens, F. R. Mooi, and J. G. Van-de-winkel, , 2001.

, Immunoglobulin A-mediated protection against Bordetella pertussis infection, Infect. Immun, vol.69, pp.4846-4850

F. E. Johansen, M. Pekna, I. N. Norderhaug, B. Haneberg, M. A. Hietala et al.,

P. Betsholtz and . Brandtzaeg, Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory componentdeficient mice, J. Exp. Med, vol.190, pp.915-922, 1999.

C. Juste, D. P. Kreil, C. Beauvallet, A. Guillot, S. Vaca et al.,

A. Gibrat, J. Van-dorsselaer, and . Doré, Bacterial protein signals are associated with Crohn's disease, Gut, vol.63, pp.1566-1577, 2014.

A. L. Kau, J. D. Planer, J. Liu, S. Rao, T. Yatsunenko et al.,

K. M. Stappenbeck, P. Maleta, K. G. Ashorn, E. R. Dewey, C. Houpt et al.,

G. , Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy, Sci. Transl. Med, vol.7, pp.276-300, 2015.

S. Kawamoto, T. H. Tran, M. Maruya, K. Suzuki, Y. Doi et al.,

. Fagarasan, The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut, Science, vol.336, pp.485-489, 2012.

M. J. Kwakkenbos, S. A. Diehl, E. Yasuda, A. Q. Bakker, C. M. Van-geelen et al.,

H. Scheeren, T. Spits, and . Beaumont, Generation of stable monoclonal antibodyproducing B cell receptor-positive human memory B cells by genetic programming, 2010.

. Med, , vol.16, pp.123-128

I. Ladjeva, J. H. Peterman, and J. Mestecky, IgA subclasses of human colostral antibodies specific for microbial and food antigens, Clin. Exp. Immunol, vol.78, pp.85-90, 1989.

J. Lee, D. R. Boutz, V. Chromikova, M. G. Joyce, C. Vollmers et al.,

C. Dekosky, J. J. Lee, E. M. Lavinder, C. Murrin, K. H. Chrysostomou et al.,

J. R. Marcotte, G. C. Mascola, F. Ippolito, S. R. Krammer, P. D. Quake et al.,

. Georgiou, Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination, Nat. Med, vol.22, pp.1456-1464, 2016.

C. Lindner, I. Thomsen, B. Wahl, M. Ugur, M. K. Sethi et al., Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota, Nat. Immunol, vol.16, pp.880-888, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01604354

J. F. Ludvigsson, M. Neovius, and L. Hammarström, Risk of Infections Among 2100, 2016.

, Individuals with IgA Deficiency: a Nationwide Cohort Study, J. Clin. Immunol, vol.36, pp.134-140

B. Macek, F. Gnad, B. Soufi, C. Kumar, J. V. Olsen et al., Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation, Mol. Cell. Proteomics MCP, vol.7, pp.299-307, 2008.

G. Magri, L. Comerma, M. Pybus, J. Sintes, D. Lligé et al.,

E. K. Yeste, C. Grasset, M. Gutzeit, M. Uzzan, M. C. Ramanujam et al.,

. Cerutti, Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals, Immunity, vol.47, 2017.

K. Moor, J. Fadlallah, A. Toska, D. Sterlin, M. L. Balmer et al.,

E. Larsen and . Slack, Analysis of bacterial-surface-specific antibodies in body fluids using bacterial flow cytometry, Nat. Protoc, vol.11, pp.1531-1553, 2016.

M. C. Moreau, R. Ducluzeau, D. Guy-grand, and M. C. Muller, Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin, Infect. Immun, vol.21, pp.532-539, 1978.

A. Nakajima, A. Vogelzang, M. Maruya, M. Miyajima, M. Murata et al.,

S. Tsuruyama, M. Yamada, H. Matsuura, D. A. Nakase, S. Peterson et al.,

. Suzuki, IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria, J. Exp. Med, vol.215, pp.2019-2034, 2018.

S. Okai, F. Usui, S. Yokota, Y. Hori-i, M. Hasegawa et al., High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice, Nat. Microbiol, vol.1, p.16103, 2016.

O. Pabst, New concepts in the generation and functions of IgA, Nat. Rev. Immunol, vol.12, pp.821-832, 2012.

S. H. Pakkanen, J. M. Kantele, Z. Moldoveanu, S. Hedges, M. Häkkinen et al.,

. Kantele, Expression of homing receptors on IgA1 and IgA2 plasmablasts in blood reflects differential distribution of IgA1 and IgA2 in various body fluids, Clin. Vaccine Immunol. CVI, vol.17, pp.393-401, 2010.

N. W. Palm, M. R. De-zoete, T. W. Cullen, N. A. Barry, J. Stefanowski et al., , 2014.

, Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease, Cell, vol.158, pp.1000-1010

B. Pasquier, P. Launay, Y. Kanamaru, I. C. Moura, S. Pfirsch et al.,

M. Benhamou, U. Pretolani, R. C. Blank, and . Monteiro, Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM, Immunity, vol.22, pp.31-42, 2005.

D. A. Peterson, N. P. Mcnulty, J. L. Guruge, and J. I. Gordon, IgA response to symbiotic bacteria as a mediator of gut homeostasis, Cell Host Microbe, vol.2, pp.328-339, 2007.

D. Ribet and P. Cossart, Pathogen-mediated posttranslational modifications: A reemerging field, Cell, vol.143, pp.694-702, 2010.

T. Rollenske, V. Szijarto, J. Lukasiewicz, L. M. Guachalla, K. Stojkovic et al., J. Schröder-Braunstein

P. Gaebelein, S. Hoffmann, K. Klein, E. Heeg, G. Nagy et al., , 2018.

, Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS Oantigen, Nat. Immunol, vol.19, pp.617-624

E. Rossato, S. Ben-mkaddem, Y. Kanamaru, M. Hurtado-nedelec, G. Hayem et al., Reversal of Arthritis by Human Monomeric IgA Through the Receptor-Mediated SH2 Domain-Containing Phosphatase 1 Inhibitory Pathway, Arthritis Rheumatol. Hoboken NJ, vol.67, pp.1766-1777, 2015.

S. J. Salter, M. J. Cox, E. M. Turek, S. T. Calus, W. O. Cookson et al.,

N. J. Parkhill, A. W. Loman, and . Walker, Reagent and laboratory contamination can critically impact sequence-based microbiome analyses, BMC Biol, vol.12, p.87, 2014.

U. Schauer, F. Stemberg, C. H. Rieger, M. Borte, S. Schubert et al., Establishment of age-dependent reference values for IgA subclasses, Clin. Chim. Acta Int. J. Clin. Chem, vol.328, pp.129-133, 2003.

C. Schneider, D. F. Smith, R. D. Cummings, K. F. Boligan, R. G. Hamilton et al.,

H. Miescher, A. Simon, T. Pashov, S. Vassilev, and . Von-gunten, The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites, Sci. Transl. Med, vol.7, pp.269-270, 2015.

I. Sekirov, S. L. Russell, L. C. Antunes, and B. B. Finlay, Gut microbiota in health and disease, Physiol. Rev, vol.90, pp.859-904, 2010.

S. R. Stowell, C. M. Arthur, R. Mcbride, O. Berger, N. Razi et al.,

J. Rodrigues, A. J. Gourdine, S. Noll, D. F. Von-gunten, Y. A. Smith et al., Microbial glycan microarrays define key features of hostmicrobial interactions, Nat. Chem. Biol, vol.10, pp.470-476, 2014.

K. Sugahara, N. B. Schwartz, and A. Dorfman, Biosynthesis of hyaluronic acid by Streptococcus, J. Biol. Chem, vol.254, pp.6252-6261, 1979.

R. N. Tsepilov and A. V. Beloded, New" Functions: Biosynthesis and Depolymerization of Hyaluronic Acid in Bacteria and Vertebrate Tissues Including during Carcinogenesis, Biochem. Biokhimiia, vol.80, pp.1093-1108, 2015.

J. R. Wilmore, B. T. Gaudette, D. Gomez-atria, T. Hashemi, D. D. Jones et al.,

A. M. Cole, D. P. Misic, D. Beiting, and . Allman, Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis, Cell Host Microbe, vol.23, pp.302-311, 2018.