Effect of Moxifloxacin Combined with Cefotaxime Compared to Cefotaxime-Gentamicin Combination on Prevention of White Matter Damage Associated with Escherichia coli Sepsis in Neonatal Rats - Sorbonne Université
Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2011

Effect of Moxifloxacin Combined with Cefotaxime Compared to Cefotaxime-Gentamicin Combination on Prevention of White Matter Damage Associated with Escherichia coli Sepsis in Neonatal Rats

Résumé

Relative to the cefotaxime-gentamicin combination, the moxifloxacin-cefotaxime combination significantly reduced microglial activation and immature oligodendrocyte cell death and delayed myelination in the developing white matter of neonatal rats with experimental Escherichia coli sepsis. These neuroprotective effects were not due to differences in in vivo bactericidal activities or in the systemic inflammatory responses and could be related to the intrinsic immunomodulatory properties of moxifloxacin. Molecular mechanisms underlying the neuroprotective effect of moxifloxacin remain to be elucidated.

Dates et versions

hal-02507054 , version 1 (12-03-2020)

Identifiants

Citer

Nolwenn Le Saché, Olivier Baud, Julien Pansiot, Hoa Pham, Valérie Biran, et al.. Effect of Moxifloxacin Combined with Cefotaxime Compared to Cefotaxime-Gentamicin Combination on Prevention of White Matter Damage Associated with Escherichia coli Sepsis in Neonatal Rats. Antimicrobial Agents and Chemotherapy, 2011, 55 (7), pp.3567-3569. ⟨10.1128/AAC.01813-10⟩. ⟨hal-02507054⟩
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