M. A. Dimopoulos, R. A. Kyle, A. Anagnostopoulos, and S. P. Treon, Diagnosis and management of Waldenstrom's macroglobulinemia, J Clin Oncol, vol.23, pp.1564-1577, 2005.

R. G. Owen, S. P. Treon, A. Al-katib, R. Fonseca, P. R. Greipp et al., Clinicopathological definition of Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia, Semin Oncol, vol.30, pp.110-115, 2003.

S. D. Wagner, V. Martinelli, and L. Luzzatto, Similar patterns of V kappa gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma, Blood, vol.83, pp.3647-3653, 1994.

J. Kriangkum, B. J. Taylor, T. Reiman, A. R. Belch, and L. M. Pilarski, Origins of Waldenstrom's macroglobulinemia: does it arise from an unusual B-cell precursor?, Clin Lymphoma, vol.5, pp.217-219, 2005.

J. Kriangkum, B. J. Taylor, S. P. Treon, M. J. Mant, A. R. Belch et al., Clonotypic IgM V/D/J sequence analysis in Waldenstrom macroglobulinemia suggests an unusual B-cell origin and an expansion of polyclonal B cells in peripheral blood, Blood, vol.104, pp.2134-2142, 2004.

S. S. Sahota, F. Forconi, C. H. Ottensmeier, D. Provan, D. G. Oscier et al., Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events, Blood, vol.100, pp.1505-1507, 2002.

J. Kriangkum, B. J. Taylor, E. Strachan, M. J. Mant, T. Reiman et al., Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery, Blood, vol.107, pp.2920-2927, 2006.

M. Muramatsu, K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai et al., Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme, Cell, vol.102, pp.553-563, 2000.

C. T. Yan, C. Boboila, E. K. Souza, S. Franco, T. R. Hickernell et al., IgH class switching and translocations use a robust non-classical end-joining pathway, Nature, vol.449, pp.478-482, 2007.

N. Mcelhinny, S. A. Snowden, C. M. Mccarville, J. Ramsden, and D. A. , Ku recruits the XRCC4-ligase IV complex to DNA ends, Mol Cell Biol, vol.20, pp.2996-3003, 2000.

P. O. Mari, B. I. Florea, S. P. Persengiev, N. S. Verkaik, H. T. Bruggenwirth et al., Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4, Proc Natl Acad Sci, vol.103, pp.18597-18602, 2006.
URL : https://hal.archives-ouvertes.fr/hal-02148382

W. J. Chng, R. F. Schop, T. Price-troska, I. Ghobrial, N. Kay et al., Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma, Blood, vol.108, pp.2755-2763, 2006.

N. C. Gutierrez, E. M. Ocio, J. De-las-rivas, P. Maiso, M. Delgado et al., Gene expression profiling of B lymphocytes and plasma cells from Waldenstrom's macroglobulinemia: comparison with expression patterns of the same cell counterparts from chronic lymphocytic leukemia, multiple myeloma and normal individuals, Leukemia, vol.21, pp.541-549, 2007.

C. S. Mitsiades, N. Mitsiades, S. P. Treon, and K. C. Anderson, Proteomic analyses in Waldenstrom's macroglobulinemia and other plasma cell dyscrasias, Semin Oncol, vol.30, pp.156-160, 2003.

E. Hatjiharissi, H. Ngo, A. A. Leontovich, X. Leleu, M. Timm et al., Proteomic analysis of waldenstrom macroglobulinemia, Cancer Res, vol.67, pp.3777-3784, 2007.

A. Perrot, C. Pionneau, S. Nadaud, F. Davi, V. Leblond et al., A unique proteomic profile on surface IgM ligation in unmutated chronic lymphocytic leukemia, Blood, vol.118, pp.1-15, 2011.
URL : https://hal.archives-ouvertes.fr/hal-02558548

G. Van-den-bergh and L. Arckens, Fluorescent two-dimensional difference gel electrophoresis unveils the potential of gel-based proteomics, Curr Opin Biotechnol, vol.15, pp.38-43, 2004.

O. Margalit, R. Somech, N. Amariglio, and G. Rechavi, Microarray-based gene expression profiling of hematologic malignancies: basic concepts and clinical applications, Blood Rev, vol.19, pp.223-234, 2005.

M. Seto, Genomic profiles in B cell lymphoma, Int J Hematol, vol.92, pp.238-245, 2010.

O. Warburg, On the origin of cancer cells, Science, vol.123, pp.309-314, 1956.

K. Kubota, From tumor biology to clinical Pet: a review of positron emission tomography (PET) in oncology, Ann Nucl Med, vol.15, pp.471-486, 2001.

N. H. Cheng, W. Zhang, W. Q. Chen, J. J. Cui, X. Butte et al., A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis, FEBS J, vol.278, pp.2525-2539, 2011.

H. Sakamoto, T. Mashima, A. Kizaki, S. Dan, Y. Hashimoto et al., Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis, Blood, vol.95, pp.3214-3218, 2000.

C. A. Neumann, D. S. Krause, C. V. Carman, S. Das, D. P. Dubey et al., Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression, Nature, vol.424, pp.561-565, 2003.

S. Y. Kim, C. E. Lee, and K. Y. , Phospholipase A(2) of peroxiredoxin 6 has a critical role in tumor necrosis factor-induced apoptosis, Cell Death Differ, vol.18, pp.1573-1583, 2011.

H. L. Asch, K. Head, Y. Dong, F. Natoli, J. S. Winston et al., Widespread loss of gelsolin in breast cancers of humans, mice, and rats, Cancer Res, vol.56, pp.4841-4845, 1996.

M. Ohtsu, N. Sakai, H. Fujita, M. Kashiwagi, S. Gasa et al., Inhibition of apoptosis by the actin-regulatory protein gelsolin, EMBO J, vol.16, pp.4650-4656, 1997.

N. M. Verrills, N. L. Liem, T. Y. Liaw, B. D. Hood, R. B. Lock et al., Proteomic analysis reveals a novel role for the actin cytoskeleton in vincristine resistant childhood leukemia--an in vivo study, Proteomics, vol.6, pp.1681-1694, 2006.

C. Enrich, C. Rentero, S. V. De-muga, M. Reverter, V. Mulay et al., Annexin A6-Linking Ca(2 þ ) signaling with cholesterol transport, Biochem Biophys Acta, vol.1813, pp.935-947, 2011.

T. Mimori, M. Akizuki, H. Yamagata, S. Inada, S. Yoshida et al., Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap, J Clin Invest, vol.68, pp.611-620, 1981.

Q. Q. Cai, A. Plet, J. Imbert, M. Lafage-pochitaloff, C. Cerdan et al., Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues, Cytogenet Cell Genet, vol.65, pp.221-227, 1994.
URL : https://hal.archives-ouvertes.fr/hal-02193240

P. R. Blier, A. J. Griffith, J. Craft, and J. A. Hardin, Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks, J Biol Chem, vol.268, pp.7594-7601, 1993.

T. M. Gottlieb and S. P. Jackson, The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen, Cell, vol.72, pp.131-142, 1993.

H. Ouyang, A. Nussenzweig, A. Kurimasa, V. C. Soares, X. Li et al., Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo, J Exp Med, vol.186, pp.921-929, 1997.

G. E. Taccioli, T. M. Gottlieb, T. Blunt, A. Priestley, J. Demengeot et al., Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination, Science, vol.265, pp.1442-1445, 1994.

C. Zhu, M. A. Bogue, D. S. Lim, P. Hasty, and D. B. Roth, Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates, Cell, vol.86, pp.379-389, 1996.

Y. Gu, J. S. Gao, Y. Weaver, D. T. Alt, and F. W. , Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination, Proc Natl Acad Sci, vol.94, pp.8076-8081, 1997.

D. O. Ferguson, J. M. Sekiguchi, S. Chang, K. M. Frank, Y. Gao et al., The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations, Proc Natl Acad Sci, vol.97, pp.6630-6633, 2000.

M. J. Difilippantonio, J. Zhu, H. T. Chen, E. Meffre, M. C. Nussenzweig et al., DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation, Nature, vol.404, pp.510-514, 2000.

C. Muller, G. Christodoulopoulos, B. Salles, and L. Panasci, DNA-Dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards, Blood, vol.92, pp.2213-2219, 1998.

E. Riballo, S. E. Critchlow, S. H. Teo, A. J. Doherty, A. Priestley et al., Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient, Curr Biol, vol.9, pp.699-702, 1999.

R. Kuppers, Mechanisms of B-cell lymphoma pathogenesis, Nat Rev Cancer, vol.5, pp.251-262, 2005.

D. Moshous, C. Pannetier, C. Rd, R. , D. Fl et al., Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis, J Clin Invest, vol.111, pp.381-387, 2003.

P. L. Roddam, S. Rollinson, M. O'driscoll, P. A. Jeggo, A. Jack et al., Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination, J Med Genet, vol.39, pp.900-905, 2002.

D. A. Hill, S. S. Wang, J. R. Cerhan, S. Davis, W. Cozen et al., Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes, Blood, vol.108, pp.3161-3167, 2006.

T. Y. Chen, J. S. Chen, W. C. Su, M. S. Wu, and C. J. Tsao, Expression of DNA repair gene Ku80 in lymphoid neoplasm, Eur J Haematol, vol.74, pp.481-488, 2005.

A. Holgersson, H. Erdal, A. Nilsson, R. Lewensohn, and L. Kanter, Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies, Exp Mol Pathol, vol.77, pp.1-6, 2004.

P. L. Roddam, J. M. Allan, A. M. Dring, L. J. Worrillow, F. E. Davies et al., Non-homologous end-joining gene profiling reveals distinct expression patterns associated with lymphoma and multiple myeloma, Br J Haematol, vol.149, pp.258-262, 2010.

A. Sacco, G. C. Issa, Y. Zhang, Y. Liu, P. Maiso et al., Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology, J Hematol Oncol, vol.3, p.38, 2010.

A. L. Shaffer, K. I. Lin, T. C. Kuo, X. Yu, E. M. Hurt et al., Blimp1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program, Immunity, vol.17, pp.51-62, 2002.

, This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License