L. Aoudjehane, P. Podevin, O. Scatton, P. Jaffray, I. Dusanter-fourt et al., Interleukin-4 induces human hepatocyte apoptosis through a Fasindependent pathway, FASEB J, vol.21, pp.1433-1444, 2007.

L. Aoudjehane, P. Boelle, G. Bisch, R. Delelo, F. Paye et al., Development of an in vitro model to test antifibrotic drugs on primary human liver myofibroblasts, Lab. Invest, vol.96, pp.672-679, 2016.

I. Bakan and M. Laplante, Connecting mTORC1 signaling to SREBP-1 activation, Curr. Opin. Lipidol, vol.23, pp.226-234, 2012.

A. Baylin, E. K. Kabagambe, X. Siles, and H. Campos, Adipose tissue biomarkers of fatty acid intake, Am. J. Clin. Nutr, vol.76, pp.750-757, 2002.

Y. L. Boteon, L. Wallace, A. P. Boteon, D. F. Mirza, H. Mergental et al., An effective protocol for pharmacological defatting of primary human hepatocytes which is non-toxic to cholangiocytes or intrahepatic endothelial cells, PLoS ONE, vol.13, 2018.

Y. L. Boteon, J. Attard, A. P. Boteon, L. Wallace, G. Reynolds et al., Manipulation of lipid metabolism during normothermic machine perfusion: effect of defatting therapies on donor liver functional recovery, Liver Transpl, vol.25, pp.1007-1022, 2019.

N. F. Brown, M. Stefanovic-racic, I. J. Sipula, and G. Perdomo, The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes, Metabolism, vol.56, pp.1500-1507, 2007.

P. Chakrabarti, T. English, J. Shi, C. M. Smas, and K. V. Kandror, Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage, Diabetes, vol.59, pp.775-781, 2010.

H. Chen, F. Shen, A. Sherban, A. Nocon, Y. Li et al., DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease, Hepatology, vol.68, pp.496-514, 2018.

I. A. De-graaf, P. Olinga, M. H. De-jager, M. T. Merema, R. De-kanter et al., Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies, Nat. Protoc, vol.5, pp.1540-1551, 2010.

J. Folch, M. Lees, S. Stanley, and G. H. , A simple method for the isolation and purification of total lipides from animal tissues, J. Biol. Chem, vol.226, pp.497-509, 1957.

J. Gautheron, M. Vucur, A. T. Schneider, I. Severi, C. Roderburg et al., The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance, Nat. Commun, vol.7, p.11869, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02176937

M. J. Go?ez-lecho?n, M. T. Donato, A. Mart??ez-romero, N. Jime?ez, J. V. Castell et al., A human hepatocellular in vitro model to investigate steatosis, Chem. Biol. Interact, vol.165, pp.106-116, 2007.

M. Gori, M. C. Simonelli, S. M. Giannitelli, L. Businaro, M. Trombetta et al., Investigating nonalcoholic fatty liver disease in a liver-on-a-chip microfluidic device, PLoS ONE, vol.11, 2016.

S. D. Henry, E. Nachber, J. Tulipan, J. Stone, C. Bae et al., Hypothermic machine preservation reduces molecular markers of ischemia/reperfusion injury in human liver transplantation, Am. J. Transpl, vol.12, pp.2477-2486, 2012.

D. Kollmann and M. Selzner, Recent advances in the field of warm ex-vivo liver perfusion, Curr. Opin. Organ Transpl, vol.22, pp.555-562, 2017.

P. Kron, A. Schlegel, L. Mancina, P. Clavien, and P. Dutkowski, Hypothermic oxygenated perfusion (HOPE) for fatty liver grafts in rats and humans, J. Hepatol, vol.68, pp.82-91, 2017.

C. Lin, H. Zhang, M. Li, X. Xiong, X. Chen et al., Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice, J. Hepatol, vol.58, pp.993-999, 2013.

J. Ling, J. Lewis, D. Douglas, N. M. Kneteman, and D. E. Vance, Characterization of lipid and lipoprotein metabolism in primary human hepatocytes, Biochim. Biophys. Acta, vol.1831, pp.387-397, 2013.

K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(???C(T)) method, Methods San Diego Calif, vol.25, pp.402-408, 2001.

M. V. Machado and H. Cortez-pinto, Non-alcoholic fatty liver disease: what the clinician needs to know, World J. Gastroenterol, vol.20, pp.12956-12980, 2014.

V. Mart??ez-cisuelo, J. Go?ez, I. Garc?á-junceda, A. Naud?, R. Cabre et al., Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice, Exp. Gerontol, vol.83, pp.130-138, 2016.

D. Mathe, R. Adam, C. Malmendier, M. Gigou, J. F. Lontie et al., Prevalence of dyslipidemia in liver transplant recipients, Transplantation, vol.54, pp.167-170, 1992.

D. Nagrath, H. Xu, Y. Tanimura, R. Zuo, F. Berthiaume et al., Metabolic preconditioning of donor organs: defatting fatty livers by normothermic perfusion ex vivo, Metab. Eng, vol.11, pp.274-283, 2009.

E. Nakadera, S. Yamashina, K. Izumi, Y. Inami, T. Sato et al., Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis, Biochem. Biophys. Res. Commun, vol.469, pp.1104-1110, 2016.

N. I. Nativ, G. Yarmush, A. Chen, D. Dong, S. D. Henry et al., Rat hepatocyte culture model of macrosteatosis: effect of macrosteatosis induction and reversal on viability and liver-specific function, J. Hepatol, vol.59, pp.1307-1314, 2013.

E. Palma, E. J. Doornebal, and S. Chokshi, Precision-cut liver slices: a versatile tool to advance liver research, Hepatol. Int, vol.13, pp.51-57, 2019.

M. Tanaka, H. Jingami, H. Otani, M. Cho, Y. Ueda et al., Regulation of apolipoprotein B production and secretion in response to the change of intracellular cholesteryl ester contents in rabbit hepatocytes, J. Biol. Chem, vol.268, pp.12713-12718, 1993.

W. Tong, L. Ju, M. Qiu, Q. Xie, Y. Chen et al., Liraglutide ameliorates non-alcoholic fatty liver disease by enhancing mitochondrial architecture and promoting autophagy through the SIRT1/SIRT3-FOXO3a pathway, Hepatol. Res, vol.46, pp.933-943, 2016.

L. R. Waskowicz, J. Zhou, D. J. Landau, E. D. Brooks, A. Lim et al., Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia, Hum. Mol. Genet, vol.28, pp.143-154, 2019.

H. Xu, X. Du, G. Liu, S. Huang, W. Du et al., The pseudokinase MLKL regulates hepatic insulin sensitivity independently of inflammation, Mol. Metab, vol.23, pp.14-23, 2019.

W. Zhou and S. Ye, Rapamycin improves insulin resistance and hepatic steatosis in type 2 diabetes rats through activation of autophagy, Cell Biol. Int, vol.42, pp.1282-1291, 2018.